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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ADP-ribosylation factor-like 4D

ARL5, ARF4L, Arl4d
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p16, CAN, ARL4, ACID, ARNO
Papers on ARL5
MiRNA expression profile and miRNA-mRNA integrated analysis (MMIA) during podocyte differentiation.
Yang et al., Tianjin, China. In Mol Genet Genomics, Jun 2015
The dual luciferase reporter assay for miR-200a/GLRX and let-7b/ARL4D confirmed the prediction of MMIA.
Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.
Sheffield et al., Iowa City, United States. In Proc Natl Acad Sci U S A, 2012
Bbs3 knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes
GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential.
Lee et al., Taipei, Taiwan. In Plos One, 2011
ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases.
Overexpression of the small GTPase Arl4D suppresses adipogenesis.
Park et al., Ch┼Ćnju, South Korea. In Int J Mol Med, 2011
The results suggest that rapid reduction of Arl4D is required for adipogenesis to proceed.
Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice.
Churchill et al., Bar Harbor, United States. In Physiol Genomics, 2010
analysis identified an epistatic interaction that plays a role in the buffering of HDL levels in C57BL/6J mice, and we have identified Arl4d as a candidate gene that mediates this effect.
Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.
Slusarski et al., Iowa City, United States. In Plos Genet, 2010
These data demonstrate that the BBS3L transcript is required for proper retinal function and organization.
Temporal ChIP-on-Chip of RNA-Polymerase-II to detect novel gene activation events during photoreceptor maturation.
Mitton et al., United States. In Mol Vis, 2009
To demonstrate the use of ChIP-on-chip predictions to find novel gene activation events, four additional genes were selected for quantitative PCR analysis (qRT-PCR analysis); these four genes have human homologs located in unidentified retinal disease regions: Solute carrier family 25 member 33 (Slc25a33), Lysophosphatidylcholine acyltransferase 1 (Lpcat1), Coiled-coil domain-containing 126 (Ccdc126), and ADP-ribosylation factor-like 4D (Arl4d).
Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.
Tanoue et al., Tokyo, Japan. In Exp Cell Res, 2009
Arl4D is a previously unknown regulator of neurite formation through cytohesin-2 and Arf6, providing another example that the functional interaction of two different small GTPases controls an important cellular function.
Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
Parsa et al., San Francisco, United States. In J Neurosurg, 2008
The authors investigated the relationship between PTEN status and the expression of a glioma-associated antigen, adenosine diphosphate-ribosylation factor 4-like (ARF4L) protein.
ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.
Lee et al., Taipei, Taiwan. In Mol Biol Cell, 2007
ARL4D is a developmentally regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of Ras-related GTPases.
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Munro et al., Cambridge, United Kingdom. In Curr Biol, 2007
Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation.
Bramham et al., Bergen, Norway. In Neural Plast, 2006
Recently, we identified five genes (neuritin, Narp, TIEG1, Carp, and Arl4d) that are coupregulated with Arc during BDNF-LTP.
Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus.
Hao et al., Anqing, China. In Mol Immunol, 2006
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.
Liang et al., Beijing, China. In Biochem Biophys Res Commun, 2005
crystal structure
Role of ARF4L in recycling between endosomes and the plasma membrane.
Tohyama et al., Suita, Japan. In Cell Mol Neurobiol, 2004
The human ADP-ribosylation factor-like protein, ARF4L is a member of the ARF family, which are small GTP-binding proteins that play significant roles in vesicle transport and protein secretion.
Identification and characterization of LASP2 gene in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2003
Some part of the LASP2/ NEBL-TEM7L-ARL8-CACNB2 locus on 10p12 was paralogous to the LASP1-TEM7-CACNB1 locus on 17q12, while the other part of the LASP2/NEBL-TEM7L-ARL8-CACNB2 locus was paralogous to the NEB-ARL5-CACNB4 locus on 2q23.
Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library.
Krakow et al., Los Angeles, United States. In Gene, 2003
ARL8 contains six exons and five introns, and encodes a 179 amino acid protein that shares homology to the other ARL proteins, especially ARL5.
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