gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ras homolog gene family, member T1

Arht1, RHOT1, Miro1, mitochondrial Rho, EMB2473
Top mentioned proteins: Rhodopsin, CAN, V1a, iMpact, Miro-2
Papers on Arht1
Miro sculpts mitochondrial dynamics in neuronal health and disease.
Kittler et al., London, United Kingdom. In Neurobiol Dis, Jan 2016
Adaptor proteins are required for this coupling and the mitochondrial Rho GTPases Miro1 and Miro2 are core components of this machinery.
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Kittler et al., London, United Kingdom. In J Neurosci, Jan 2016
The mitochondrial Rho-GTPase 1 protein (Miro1) regulates mitochondrial trafficking and detachment from the microtubule transport network to control activity-dependent mitochondrial positioning in neurons.
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.
Harper et al., Boston, United States. In Proc Natl Acad Sci U S A, Jun 2015
Combining p-S65-UB and p-S65-PARKIN in vitro showed accelerated transfer of nonphosphorylated UB to PARKIN itself, its substrate mitochondrial Rho GTPase (MIRO), and UB.
Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1.
Bardien et al., Cape Town, South Africa. In Eur J Neurosci, May 2015
To further elucidate a commonality between these three proteins, bioinformatics analysis established that Miro (RHOT1) interacts with parkin and PINK1, and HSPA4 interacts with all three proteins.
Role of RHOT1 on migration and proliferation of pancreatic cancer.
Jiang et al., Shanghai, China. In Am J Cancer Res, 2014
In this study, we investigated the role of Ras homolog family member T1 (RHOT1), a new member of Rho GTPases in PC.
Miro1 deficiency in amyotrophic lateral sclerosis.
Wang et al., Cleveland, United States. In Front Aging Neurosci, 2014
Miro1, a RhoGTPase also referred to as Rhot1, is a key regulator of mitochondrial movement linking mitochondria and motor proteins.
MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology.
Tang, Singapore, Singapore. In Cells, 2014
The evolutionarily-conserved mitochondrial Rho (MIRO) small GTPase is a Ras superfamily member with three unique features.
[CK2beta promotes Pink1/Parkin-mediated MIRO1 degradation].
Jiang et al., In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2014
Studies have suggested that PINK1FL can selectively accumulate at the surface of damaged mitochondria and cooperate with another Parkinson's Disease-related protein PARKIN to trigger the degradation of MIRO1, a mitochondria trafficking regulator.
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Mekalanos et al., Boston, United States. In Cell Host Microbe, 2014
We describe a Vibrio cholerae Type 3 secretion system effector VopE that localizes to mitochondria during infection and acts as a specific GTPase-activating protein to interfere with the function of mitochondrial Rho GTPases Miro1 and Miro2.
Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease.
Shaw et al., Fukuoka, Japan. In Proc Natl Acad Sci U S A, 2014
Calcium-binding mitochondrial Rho (Miro) GTPases attach mitochondria to motor proteins for anterograde and retrograde transport in neurons.
Miro1: new wheels for transferring mitochondria.
Shirihai et al., Boston, United States. In Embo J, 2014
In this issue of The EMBO Journal, the group of Anurag Agrawal shows that mitochondrial transfer is dependent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial movement.
Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.
Glatzel et al., In J Clin Invest, 2014
In PS1-E280A tissue, ER/mitochondria tethering was impaired, Ca2+ channels IP3Rs and CACNA1A were downregulated, and Ca2+-dependent mitochondrial transport proteins MIRO1 and KIF5C were reduced.
Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.
Kittler et al., London, United Kingdom. In Biochem Soc Trans, 2013
One of the core components of this machinery, the mitochondrial Rho GTPases Miro1 (mitochondrial Rho 1) and Miro2 have received special attention due to their Ca2+-sensing and GTPase abilities, marking Miro an exceptional candidate for co-ordinating mitochondrial dynamics and intracellular signalling pathways.
Alternative splicing in osteoclasts and Paget's disease of bone.
Roux et al., In Bmc Med Genet, 2013
The corresponding genes included LGALS8, RHOT1, CASC4, USP4, TBC1D25, and PIDD.
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
Soriano et al., Barcelona, Spain. In Nat Commun, 2011
Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Schwarz et al., Boston, United States. In Cell, 2011
Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway.
MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis.
Tsutsumi et al., Tokyo, Japan. In Plant Cell Rep, 2011
proper mitochondrial morphology and intracellular distribution are maintained by MIRO1 and are vital for embryonic cell division
Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis.
Bones et al., Trondheim, Norway. In Plos One, 2010
MIRO1 and MIRO2 are unequally redundant and that a proportion of the miro1(+/-)/miro2(-/-) plants haploid gametes displays the complete null phenotype of MIRO GTPase function at key developmental stages.
GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
Kittler et al., London, United Kingdom. In Mol Cell Neurosci, 2009
These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.
Low-Dose UVA Illumination of Differentiating Stromal Cells Reveals Diverse Effects on Cell-Mediated Mineralisation in Culture.
Ben-Bassant et al., Jerusalem, Israel. In Lasers Med Sci, 1999
Thus, we have shown that low UVA dose modulates mineralisation together with modulation of mitochondrial Rho retention.
share on facebooktweetadd +1mail to friends