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Rho GTPase activating protein 6

ARHGAP6, Rho GTPase activating protein 6
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoGAP, Actin, ACID, STEP
Papers on ARHGAP6
Inhibitory effects of Arhgap6 on cervical carcinoma cells.
Yin et al., Shanghai, China. In Tumour Biol, Jan 2016
UNASSIGNED: Ras homology GTPase activation protein 6 (Arhgap6), as a member of the rhoGAP family of proteins, performs vital functions on the regulation of actin polymerization at the plasma membrane during several cellular processes.
Epigenetic regulation of KLHL34 predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.
Kim et al., Seoul, South Korea. In Int J Radiat Oncol Biol Phys, Apr 2015
RESULTS: Genome-wide screening identified 7 hypermethylated CpG sites (DZIP1 cg24107021, DZIP1 cg26886381, ZEB1 cg04430381, DKK3 cg041006961, STL cg00991794, KLHL34 cg01828474, and ARHGAP6 cg07828380) associated with preoperative CRT responses.
Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.
Kadler et al., Manchester, United Kingdom. In Plos One, 2013
Indeed, we showed that expression of Arhgap6 (a closely related RhoGAP) was upregulated in Arhgap28-null bone tissue.
CTCF and cohesin cooperatively mediate the cell-type specific interchromatin interaction between Bcl11b and Arhgap6 loci.
Zhao et al., Shanghai, China. In Mol Cell Biochem, 2012
Using a conserved CTCF binding site on the Bcl11b locus as bait, an interaction partner at the Arhgap6 locus on a different chromosome was identified by 4C.
Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6.
Simmer et al., Ann Arbor, United States. In Plos One, 2011
About 90% of amelogenin expression is from AMELX, which is nested within intron 1 of the gene encoding Rho GTPase activating protein 6 (ARHGAP6).
Differential gene expression between African American and European American colorectal cancer patients.
Keku et al., Chapel Hill, United States. In Plos One, 2011
Ten-fold cross validation demonstrated that following 10 genes can predict ethnicity with an accuracy of 94%: CRYBB2, PSPH, ADAL, VSIG10L, C17orf81, ANKRD36B, ZNF835, ARHGAP6, TRNT1 and WDR8.
Effects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance.
Leslie et al., Albuquerque, United States. In Oncol Rep, 2011
We propose that down-regulation of ARHGAP6 and MMP15 transcripts indicates that tumors are sensitive to bevacizumab whereas inhibition of PKCδ- or S6K-dependent signaling and up-regulation of TNFRS4 or MMP13 and MMP14 mark a developing resistance to bevacizumab therapy.
X chromosome and suicide.
Turecki et al., Montréal, Canada. In Mol Psychiatry, 2011
Six genes within these regions, Rho GTPase-activating protein 6, adaptor-related protein complex 1 sigma 2 subunit, glycoprotein M6B, ribosomal protein S6 kinase 90  kDa polypeptide 3, spermidine/spermine N(1)-acetyltransferase 1 and THO complex 2, were found to be differentially expressed in suicide completers.
Putting into practice domain-linear motif interaction predictions for exploration of protein networks.
Travé et al., Illkirch-Graffenstaden, France. In Plos One, 2010
Taking into account these limitations, we identified several novel putative interactions between PDZ domains of MAGI1 and SCRIB and the C-termini of the proteins FZD4, ARHGAP6, NET1, TANC1, GLUT7, MARCH3, MAS, ABC1, DLL1, TMEM215 and CYSLTR2.
Identification of Rho GTPase activating protein 6 isoform 1 variant as a new molecular marker in human colorectal tumors.
Li et al., Changsha, China. In Pathol Oncol Res, 2010
the RhoGAP6 isoform 1 variant might serve as a biomarker for the development and progression of colorectal cancer
Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.
Kupershmidt et al., Nashville, United States. In J Mol Cell Cardiol, 2009
One such gene encodes the worm ortholog of the rho-GTPase activating protein 6 (ARHGAP6).
Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality.
Naor et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2008
Using a proteomic approach, we identified ARHGAP6, a RhoGAP, as an ERK substrate in PMA-stimulated human spermatozoa.
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Pawelczyk et al., Gdańsk, Poland. In Int J Biochem Cell Biol, 2007
Human ARHGAP6 protein possessing GTPase stimulating activity for RhoA on the catalytic properties of PLC-delta1, was studied.
Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells.
Lagneaux et al., Brussels, Belgium. In Bmc Genomics, 2007
Other genes are involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor (FK506, ARHGAP6, CDKRAP2, PMCH, GFPT2, GRIA3, MCT6, BDNF, PENK, amphiregulin, neurofilament 3, Epha4, synaptotagmin).
Evolutionary history of sex-linked mammalian amelogenin genes.
Takahata et al., Hayama, Japan. In Cells Tissues Organs, 2006
Amelogenin (AMEL) arose prior to the emergence of tetrapods and transposed into an intron of the Rho GTPase-activating protein 6 gene.
Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice.
Van den Veyver et al., Houston, United States. In Mamm Genome, 2001
Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
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