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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Rho GTPase activating protein 18

ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoGAP, Akt, CAN, E-selectin
Papers on ARHGAP18
Novel endogenous angiogenesis inhibitors and their therapeutic potential.
Ge et al., Singapore, Singapore. In Acta Pharmacol Sin, Oct 2015
In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA.
HLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population.
Li et al., Beijing, China. In Int J Rheum Dis, Jun 2015
We investigated the linkage between putative AAV-related genes (HLA-DPB1, ARHGAP18, CD226, CTLA-4, MOSPD2 and PRTN3) and AAV in a Han Chinese population.
YAP is essential for tissue tension to ensure vertebrate 3D body shape.
Furutani-Seiki et al., Tokyo, Japan. In Nature, Jun 2015
By analysing YAP function in 3D spheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of YAP in controlling tissue tension.
High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.
Hosokawa et al., Japan. In Gene, Apr 2015
(56%, NKAIN2), 6q22.33 (67%, ARHGAP18), 6q25.1 (67%, UST), 7q13 (56%, ADCY1), 12q13.13
Caveolae control the anti-inflammatory phenotype of senescent endothelial cells.
Gamble et al., Sydney, Australia. In Aging Cell, Feb 2015
Senescent EC induced by either the overexpression of ARHGAP18/SENEX or by H₂O₂ showed significantly increased numbers of caveolae and associated proteins Caveolin-1, cavin-1 and cavin-2.
Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy.
Jun et al., Baltimore, United States. In Exp Eye Res, 2014
In addition, increased expression of CDKN2A and its transcriptional activators ETS1 and ARHGAP18 (SENEX) along with decreased expression of CDKN2A inhibitor ID1 were detected in FECD samples.
ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.
Gamble et al., Australia. In Small Gtpases, 2013
Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro-angiogenic signaling and promoting vascular stability.
Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells.
Gamble et al., Sydney, Australia. In Aging (albany Ny), 2013
However, we have previously shown that senescence induced by overexpression ofSENEX (or ARHGAP18), in endothelial cells results in an anti-inflammatory phenotype.
Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies.
Ning et al., Collierville, United States. In Plos One, 2013
Moreover, we profiled the IRF4 transcriptome in the context of EBV latent infection, and confirmed several genes including IFI27, IFI44, GBP1, and ARHGAP18, as well as CFLAR as novel targets for IRF4.
Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.
Fehon et al., Chicago, United States. In Mol Biol Cell, 2013
RhoA, a small GTPase, regulates epithelial integrity and morphogenesis by controlling filamentous actin assembly and actomyosin contractility.
Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.
Ciudad et al., Barcelona, Spain. In Biochem Pharmacol, 2013
We observed binding of Sp1 to the promoters of RAB20, FGF21, IHPK2, ARHGAP18, NPM3, SRSF7, CALM3, PGD and Sp1 itself.
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
Giandomenico et al., Uppsala, Sweden. In Plos One, 2011
Unexpectedly, six novel genes were found to be upregulated by octreotide: annexin A1 (ANXA1), rho GTPase-activating protein 18 (ARHGAP18), epithelial membrane protein 1 (EMP1), growth/differentiation factor 15 (GDF15), TGF-beta type II receptor (TGFBR2) and tumour necrosis factor (ligand) superfamily member 15 (TNFSF15).
Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.
Toda et al., Kōbe, Japan. In Plos One, 2011
ARHGAP18, related to Rho GTPase, was identified in pair-wise methylation status analysis and validated via direct bisulfite sequencing and quantitative RT-PCR.
ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.
Senga et al., Nagoya, Japan. In Mol Biol Cell, 2011
The results define ARHGAP18 as one of the crucial factors for the regulation of RhoA for the control of cell shape, spreading, and migration.
Identifying gene regulatory networks in schizophrenia.
Xie et al., Irvine, United States. In Neuroimage, 2010
Several of these genes (RSRC1, ARHGAP18, ROBO1-ROBO2, GPC1, TNIK, and CTXN3-SLC12A2) have functions related to progenitor cell proliferation, migration, and differentiation, cytoskeleton reorganization, axonal connectivity, and development of forebrain structures.
Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.
Gamble et al., Sydney, Australia. In Blood, 2010
identification of a novel gene, SENEX, that regulates stress induced premature senescence pathways in endothelial cells involving p16(INK4a) and retinoblastoma protein activation
Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.
Macciardi et al., Irvine, United States. In Mol Psychiatry, 2009
This study use Functional MRI and Genome Wide Association Analysis indentic novel gene(ARHGAP18) associated with schizophrenia.
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