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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: GAP, p16, ARF6, Rhodopsin, Actin
Papers on ARAP2
The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic.
Randazzo et al., Bethesda, United States. In J Biol Chem, 2014
We tested this idea by comparing the Arf6 GAPs ARAP2 and ACAP1.
Genome-wide association study identifies quantitative trait loci affecting hematological traits in an F2 intercross between Landrace and Korean native pigs.
Lim et al., Chinju, South Korea. In Anim Genet, 2014
Our results include the identification of five significant SNPs within five candidate genes (KIT, IL15, TXK, ARAP2 and ERG) for hematopoiesis.
Genetic variations in TP53 binding sites are predictors of clinical outcomes in prostate cancer patients.
Bao et al., Kao-hsiung, Taiwan. In Arch Toxicol, 2014
ARAP2 rs1444377 and TRPS1 rs722740 were associated with advanced stage prostate cancer.
Prenatal diagnosis and molecular cytogenetic characterization of a de novo proximal interstitial deletion of chromosome 4p (4p15.2→p14).
Wang et al., Taipei, Taiwan. In Gene, 2013
We review the phenotypic abnormalities of previously reported patients with similar proximal interstitial 4p deletions, and we discuss the functions of the genes of RBPJ, CCKAR, STIM2, PCDH7 and ARAP2 that are deleted within this region.
ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.
Randazzo et al., Bethesda, United States. In J Biol Chem, 2013
At least six ADP-ribosylation factor (Arf) GTPase-activating proteins (GAPs), including ARAP2 (an Arf6 GAP), are implicated in regulation of FAs but the mechanisms for most are not well defined.
Differential effect of oxidative or excitotoxic stress on the transcriptional profile of amyotrophic lateral sclerosis-linked mutant SOD1 cultured neurons.
Borg et al., Saint-Étienne, France. In J Neurosci Res, 2011
The most up-regulated genes following H(2)O(2) treatment were involved in cytoskeletal organization and axonal transport, such as ARAP2, KIF17, and DKK2, or in trophic factors pathways, such as insulin-like growth factor-binding protein 4 (IGFBP4), FGF17, and serpin2.
Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes.
Ireton et al., Orlando, United States. In Infect Immun, 2010
Our findings indicate that ARAP2 promotes InlB-mediated entry of Listeria monocytogenes in part, by antagonizing the host GTPase Arf6.
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.
Randazzo et al., Bethesda, United States. In J Cell Sci, 2006
ARAP2 is an Arf6GAP that functions downstream of RhoA to regulate focal adhesion dynamics.
ARAP1: a point of convergence for Arf and Rho signaling.
Randazzo et al., Bethesda, United States. In Mol Cell, 2002
We have identified ARAP1 and ARAP2 and examined ARAP1 as a possible link between phosphoinositide-, Arf-, and Rho-mediated cell signaling.
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