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Arachidonate 12-lipoxygenase

Arachidonate 12-Lipoxygenase, 12-LOX, platelet-type 12-lipoxygenase
Top mentioned proteins: lysyl oxidase, ACID, 5-lipoxygenase, cyclooxygenase, Arachidonate 15-Lipoxygenase
Papers on Arachidonate 12-Lipoxygenase
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Yang et al., Houston, United States. In Cancer Res, Feb 2016
This effect was ascribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE).
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.
Ozanne et al., Cambridge, United Kingdom. In Faseb J, Jan 2016
Maternal obesogenic diet was associated with increased mitochondrial DNA biogenesis (copy number P < 0.05; transcription factor A, mitochondrial expression P < 0.05), increased mitochondrial antioxidant defenses [manganese superoxide dismutase (MnSOD) P < 0.05; copper/zinc superoxide dismutase P < 0.05; glutathione peroxidase 4 P < 0.01] and increased lipoxygenase expression (arachidonate 12-lipoxygenase P < 0.05; arachidonate 15-lipoxygenase P < 0.05) in the ovary.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
12-LOX is an isoform expressed in epithelial cells and myeloid cells including platelets.
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
Boilard et al., Québec, Canada. In Proc Natl Acad Sci U S A, Aug 2015
Mechanistically, 12(S)-HETE is produced through the concerted activity of secreted phospholipase A2 IIA (sPLA2-IIA), present in inflammatory fluids, and platelet-type 12-lipoxygenase (12-LO), expressed by platelet MPs.
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity.
Ögmundsdóttir et al., Reykjavík, Iceland. In Prostaglandins Leukot Essent Fatty Acids, Jul 2015
Protolichesterinic acid (PA), a lichen metabolite, inhibits 5- and 12-LOX and has anti-proliferative effects on various cancer cell lines.
Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases.
Reddanna et al., Hyderābād, India. In Bmc Res Notes, 2014
The alignment of AA binding sites in the seven enzymes COX-1, COX-2, 5-LOX, 12-LOX, 15-LOX and plant soybean LOX-1 and LOX-3 indicated a common pattern of five common interacting groups.
Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism.
Chen et al., Wuhan, China. In Evid Based Complement Alternat Med, 2014
The mechanisms of tumorigenesis and cell apoptosis induced by SD extracts may be associated with decreasing the ratio of bcl-2 and bax mRNA level, activating caspase-3, suppressing survivin, and decreasing the gene expression of COX-2, 5-LOX, FLAP, and 12-LOX mRNA.
Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies.
Ahmadi et al., Kermānshāh, Iran. In Daru, 2014
Among the lipoxygenases, the 5-LOX, 12-LOX and 15-LOX are more important in the cause of neoplastic disorders.
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Honn et al., Detroit, United States. In Mol Cancer, 2014
In a screen for proteins that interacted with, and thereby potentially regulated, the human platelet-type 12-lipoxygenase (12-LOX, ALOX12), we identified the integrin β4 (ITGB4).
Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation.
Zivkovic et al., Amiens, France. In Plos One, 2014
RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs.
Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product.
Cavalca et al., Milano, Italy. In J Chromatogr B Analyt Technol Biomed Life Sci, 2014
While the importance of cyclooxygenase (COX) in platelet function has been amply elucidated, the identification of the role of 12-lipoxygenase (12-LOX) and of its stable metabolite, 12-hydroxyeicosatretraenoic acid (12-HETE), has not been clarified as yet.
Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1
Maloney et al., Bethesda, United States. In Unknown Journal, 2013
Toward this end, we employed a quantitative high-throughput (qHTS) screen against ∼74,000 small molecules which led to the discovery of ML351, a novel chemotype for 15-LOX-1 inhibition, that displays nanomolar potency (IC50 = 200 nM) and excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2.
Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase
Maloney et al., Bethesda, United States. In Unknown Journal, 2013
Our group has particular interest in platelet-type 12-(S)-LOX (12-LOX) because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis and cancer [7-11].
Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.
Zhang et al., Shanghai, China. In Osteoporos Int, 2012
The results suggest that the genetic polymorphisms in both human ALOX12 and ALOX15 may contribute to variations in the peak BMD of Chinese women.
DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood.
Sunyer et al., Barcelona, Spain. In Am J Respir Crit Care Med, 2012
DNA hypomethylation associated with persistent wheezing in childhood
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Marian et al., Vienna, Austria. In Exp Cell Res, 2012
12(S)-LOX expression in inflammatory areas of colorectal tumours has the capacity to induce an invasive phenotype in colorectal cancer cells and could be targeted for therapy.
Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
Praticò et al., Philadelphia, United States. In Ann Neurol, 2012
Overexpression of 12/15-lipoxygenase leads to increased levels of beta-secretase-1 mRNA and protein, a significant elevation in amyloid beta levels and deposition, and a worsening of memory deficits in Alzheimer's disease transgenic mice.
Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer.
Dey et al., New Delhi, India. In Plos One, 2011
ALOX12 may have a role in growth of breast cancer, and its inhibition may be a strategy for inhibiting tumor growth
Tocotrienols: the lesser known form of natural vitamin E.
Sen et al., Columbus, United States. In Indian J Exp Biol, 2011
Tocotrienols have garnered much of this recent attention, and in particular alpha-tocotrienol has been shown to be the most potent neuroprotective form of vitamin E. Protection exclusively mediated through tocotrienols has been arbitrated to many mechanisms including inhibition of 12-LOX, c-Src, PLA2 and through up-regulation of MRP1.
Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.
Hong et al., New York City, United States. In Nature, 2003
Furthermore, cGMP signalling activated by an arachidonate 12-lipoxygenase metabolite suppresses LCC activity triggered by netrin-1, and is required for growth-cone repulsion mediated by the DCC-UNC5 receptor complex.
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