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Ring finger protein 14

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: PTC3, Hic-5, CAN, SRC-1, Src
Papers on ARA54
Neuropathy Target Esterase Is Degraded by the Ubiquitin-Proteasome Pathway with ARA54 as the Ubiquitin Ligase.
Wu et al., Beijing, China. In Biochemistry, Jan 2016
Here we further reveal that androgen receptor-associated protein 54 (ARA54) regulated the ubiquitin-proteasome degradation of NTE.
Genome-wide identification and characterization of RBR ubiquitin ligase genes in soybean.
Gai et al., Nanjing, China. In Plos One, 2013
Phylogenetic analyses indicated all 24 soybean RBR proteins are most related to the RBR proteins from Phaseolus vulgaris, and could be classified into seven groups including Ariadne A, Ariadne B, ARA54, Plant IIA, Plant IIB, Plant IIC, and Helicase.
Analysis of androgen receptor and anti-Müllerian hormone pathways in human granulosa cells under luteinizing hormone treatment.
Kang et al., Kao-hsiung, Taiwan. In Reprod Biol Endocrinol, 2012
METHODS: Levels of reproductive hormones in the pre-ovulatory follicular fluid and the expression levels of LHR (luteinizing hormone receptor), AR, SOX9, AMH, AR-associated protein 54(ARA54)and ARA70 were determined in granulosa-luteal cells by real-time reverse-transcription PCR.
Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53.
Chen et al., Hangzhou, China. In Asian J Androl, 2010
Transgelin, known as an ARA54-associated AR inhibitor, can suppress AR function in LNCaP cells.
Diversification and Specialization of Plant RBR Ubiquitin Ligases.
Marín, Valencia, Spain. In Plos One, 2009
METHODOLOGY/PRINCIPAL FINDINGS: Phylogenetic and structural data confirm that just four RBR subfamilies (Ariadne, ARA54, Plant I/Helicase and Plant II) exist in viridiplantae.
RBR ubiquitin ligases: Diversification and streamlining in animal lineages.
Marín, Valencia, Spain. In J Mol Evol, 2009
RBR genes can be classified into subfamilies (Parkin, Ariadne, Dorfin, ARA54, etc.) according to sequence and structural data.
Mapping of sex hormone receptors and their modulators along the nephron of male and female mice.
Crambert et al., Paris, France. In Febs Lett, 2009
Only one gene tested among 11 (ARA54) exhibits a gender difference in the level of its expression.
Expression of androgen receptor co-regulators in the testes of men with azoospermia.
Huang et al., Kao-hsiung, Taiwan. In Fertil Steril, 2008
Differential localization of ARA54 may play an important role in testicular development and spermatogenesis in humans.
ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells.
Kitagawa et al., Hamamatsu, Japan. In Carcinogenesis, 2007
mRNA expression of ARA54 correlates with that of cyclin D1 in human colon carcinoma cells, indicating that ARA54 is not only involved in the regulation of cyclin D1 expression in cultured cell lines but also in clinical cancer specimens.
Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54.
Chang et al., Rochester, United States. In Endocrinology, 2007
Dual functional roles for ARA54 as an AR coregulator directly and as a mediator for the suppressive effect of hnRNP A1 indirectly.
Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.
Chang et al., Rochester, United States. In Mol Endocrinol, 2007
ARA54, might have dual in vivo roles functioning as both a direct coactivator and as an indirect mediator in AR function.
Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain.
Dubbink et al., Rotterdam, Netherlands. In J Biol Chem, 2006
Leu+4 to Met or Phe substitutions in the FXXLF motifs of AR cofactors ARA54 and ARA70 were also compatible with strong AR LBD binding.
Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines.
Mowszowicz et al., Paris, France. In Prostate, 2003
ARA54 role in prostate carcinoma progression may in may involve function as androgen receptor coactivator and focal adhesion protein
Identification and characterization of androgen receptor associated coregulators in prostate cancer cells.
Chang et al., Rochester, United States. In J Biol Regul Homeost Agents, 2001
The LBD-interacting proteins ARA70, ARA55 and ARA54 were first characterized and ARA70 was found to have a relatively higher specificity for the AR in human prostate cancer DU145 cells.
Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer.
Chang et al., Rochester, United States. In J Formos Med Assoc, 2000
Several new androgen receptor (AR) coregulators, including ARA70, ARA55, ARA54, ARA160 and ARA24, associated with the N-terminal or the ligand-binding domain (LBD) of AR, have been identified by our group.
Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators.
Chang et al., Rochester, United States. In Keio J Med, 1999
Several new androgen receptor (AR) cofactors, associated to the ligand binding domain of AR, have been identified by our group and named AR associated protein (ARA)70, ARA55, and ARA54.
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