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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Aquaporin 1

Aquaporin 1, AQP1, Aquaporin
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: AQP4, CAN, V1a, HAD, AQP5
Papers using Aquaporin 1 antibodies
Murine middle ear inflammation and ion homeostasis gene expression.
Juhn Steven K., In PLoS ONE, 2010
... Aquaporin 4Rabbit Affinity Purified Polyclonal AntibodyAbcam Inc ...
Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression
Bill Roslyn M. et al., In The Journal of Biological Chemistry, 2008
... Polyclonal rabbit anti-AQP1 was from Alamone (Jerusalem, Israel), secondary goat anti-rabbit IgG-FITC was from Santa Cruz Biotechnology (Santa Cruz, CA), and ...
Papers on Aquaporin 1
Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders.
Di Benedetto et al., München, Germany. In Curr Opin Pharmacol, Feb 2016
Dysfunctional astrocytes characterize mood disorders, here showcased by deregulation of the astrocyte end-feet protein Aquaporin-4 around blood vessels and, hypothetically, of the astrocyte-specific phagocytic protein MEGF10 to shape synapses.
Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
Conner et al., Warwick, United Kingdom. In J Biol Chem, Feb 2016
UNASSIGNED: The aquaporins (AQP) family of integral membrane protein channels mediate cellular water and solute flow.
Influence of AQP1 on cell adhesion, migration and tumor sphere formation in malignant pleural mesothelioma is substratum and histological type dependent.
Zarogiannis et al., In Am J Physiol Lung Cell Mol Physiol, Feb 2016
MPM cells express aquaporin-1 (AQP1) that in other cancers has been shown to participate in the tumor metastasis processes.
The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells.
Xu et al., Nanjing, China. In Tumour Biol, Feb 2016
Aquaporin 3 (AQP3) belongs to a family of transmembrane channels that are important in transporting water, glycerol, and other small molecules across the cell membrane.
Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease.
Hu et al., Nanjing, China. In Neuroscience, Feb 2016
UNASSIGNED: Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD).
Galactorrhea in a Patient With Aquaporin-4 Antibody-positive Neuromyelitis Optica Spectrum Disorder: A Case Report and Review of the Literature.
Tamaoka et al., Sendai, Japan. In Neurologist, Dec 2015
The hypothalamus is becoming known as an area highly expressing aquaporin-4 and frequently involved in intracranial lesions of patients with neuromyelitis optica (NMO).
Dynamic regulation of aquaporin-4 water channels in neurological disorders.
Linninger et al., Chicago, United States. In Croat Med J, Dec 2015
Aquaporin-4 water channels play a central role in brain water regulation in neurological disorders.
Struijk et al., Amsterdam, Netherlands. In Perit Dial Int, Nov 2015
This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1.
Urine Aquaporin-2: A Promising Marker of Response to the Arginine Vasopressin Type-2 Antagonist, Tolvaptan in Patients with Congestive Heart Failure.
Kinugawa et al., Tokyo, Japan. In Int J Mol Sci, 2014
Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney.
Aquaporin in the proliferation and apoptosis of diabetic myocardial cells.
Sun et al., Yantai, China. In Genet Mol Res, 2014
The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis.
Physiological roles of aquaporin-4 in brain.
Ottersen et al., In Physiol Rev, 2013
Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces.
Aquaporin water channels in the nervous system.
Verkman et al., London, United Kingdom. In Nat Rev Neurosci, 2013
AQP1 is expressed in the choroid plexus, where it facilitates cerebrospinal fluid secretion, and in dorsal root ganglion neurons, where it tunes pain perception.
Salt-induced downregulation of renal aquaporins is prevented by losartan.
Rosón et al., Buenos Aires, Argentina. In Regul Pept, 2012
Increased intrarenal Ang II in rats fed with a high-salt diet downregulates renal AQP-1 and AQP-2 expressions.
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1.
Shimoda et al., Baltimore, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
Hypoxia induces a pulmonary arterial smooth muscle cell -specific increase in [Ca(2+)](i) that results in increased AQP1 protein levels and cell migration.
Aquaporin 4 and neuromyelitis optica.
Verkman et al., London, United Kingdom. In Lancet Neurol, 2012
The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our understanding of the disease.
Genetic ablation of Slc4a10 alters the expression pattern of transporters involved in solute movement in the mouse choroid plexus.
Praetorius et al., Århus, Denmark. In Am J Physiol Cell Physiol, 2012
AQP1 abundance is 42.7% lower in the choroid plexus epithelium of solute carrier family 4 sodium bicarbonate cotransporter-like (Slc4a10)-deficient mice.
The expression of aquaporin 1 and 5 in uterine leiomyomata in premenopausal women: a preliminary study.
Skowronska et al., Olsztyn, Poland. In Reprod Biol, 2012
expression of aquaporin 1 and 5 was higher in uterine leiomyomata than in unaffected uteri
Aquaporin 1 and aquaporin 4 are involved in invasion of lung cancer cells.
Dai et al., Huzhou, China. In Clin Lab, 2011
We found AQP1 and AQP4 in lung cancer cell extravasation and spread, which may provide a functional explanation for the expression of AQP1 and AQP4 in lung cancer tissues and lung cancer cell lines.
Fluid transport across leaky epithelia: central role of the tight junction and supporting role of aquaporins.
Fischbarg, Buenos Aires, Argentina. In Physiol Rev, 2010
Aquaporin (AQP) 1 is the only AQP present in these cells, and its deletion in AQP1 null mice significantly affects cell osmotic permeability (by ∼40%) but fluid transport much less (∼20%), which militates against the presence of sizable water movements across the cell.
Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching.
Verkman et al., San Francisco, United States. In Nat Methods, 2006
Our results reveal a remarkable and previously unrecognized slowing of diffusion deep in tumors, which correlated with the differing tissue architectures of tumor periphery versus core, and with altered tumor vasculature produced by aquaporin-1 deletion.
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