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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Aquaporin 4

AQP4, aquaporin-4
water channel protein that mediates water transport across plasma membranes in kidney; linked to hypothyroidism and brain edema following trauma [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Aquaporin 1, HAD, CAN, AGE, V1a
Papers on AQP4
Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
Conner et al., Warwick, United Kingdom. In J Biol Chem, Feb 2016
Using a variety of biophysical techniques, we show that mutations to an intracellular loop (loop D) of human AQP4 reduce oligomerization.
Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease.
Hu et al., Nanjing, China. In Neuroscience, Feb 2016
UNASSIGNED: Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD).
Negative impact of AQP-4 channel inhibition on survival of retinal ganglion cells and glutamate metabolism after crushing optic nerve.
Ikeda et al., Ōsaka, Japan. In Exp Eye Res, Feb 2016
UNASSIGNED: The purpose of this study was to determine whether inhibition of aquaporin 4 (AQP4) is neuroprotective or neurodestructive after crushing the optic nerve of rats.
Galactorrhea in a Patient With Aquaporin-4 Antibody-positive Neuromyelitis Optica Spectrum Disorder: A Case Report and Review of the Literature.
Tamaoka et al., Sendai, Japan. In Neurologist, Dec 2015
The hypothalamus is becoming known as an area highly expressing aquaporin-4 and frequently involved in intracranial lesions of patients with neuromyelitis optica (NMO).
Present and Future Therapies in Neuromyelitis Optica Spectrum Disorders.
Gold et al., Bochum, Germany. In Neurotherapeutics, Dec 2015
NMOSD are characterized by inflammatory lesions in the optic nerves, spinal cord, and central parts of the brain, as well as an autoimmune process directed against aquaporin-4.
Therapy of NMO spectrum disorders.
Mukherjee et al., Calcutta, India. In Ann Indian Acad Neurol, Sep 2015
Neuromyelitis optica (NMO) is an autoimmune demyelinating condition of the central nervous system often associated with aquaporin-4 (AQP4) autoantibodies manifesting as severe optic neuritis and long segment myelitis with tendency to relapse.
Neuromyelitis optica spectrum disorders: An update.
Pandit, Mangalore, India. In Ann Indian Acad Neurol, Sep 2015
Novel biomarkers other than aquoporin 4 Immunoglobulin G (anti AQP4-IgG) have been discovered which may have clinical relevance.
Effect of progesterone intervention on the dynamic changes of AQP-4 in hypoxic-ischaemic brain damage.
Wang et al., Xinxiang, China. In Int J Clin Exp Med, 2014
To observe the effect of progesterone (PROG) on blood-brain barrier (BBB) permeability, brain tissue water content and dynamic changes of aquaporin-4 (AQP-4) in neonatal rats with hypoxic-ischaemic brain damage (HIBD).
Screening feature genes of astrocytoma using a combined method of microarray gene expression profiling and bioinformatics analysis.
Yang et al., Huzhou, China. In Int J Clin Exp Med, 2014
A total of 3072 genes, including 1799 up-regulated genes and 1273 down-regulated genes, were filtered as DEGs, and we learnt that the DEGs including AQP4, PMP2, SRARCL1 and SLC1A2CAMs etc and that AQP4 was most significantly related to cell osmotic pressure.
Plasmablast in the pathology of multiple sclerosis.
Yamamura et al., In Nihon Rinsho Meneki Gakkai Kaishi, 2014
Interestingly, an MS-like autoimmune disease neuromyelitis optica (NMO) is exclusively resistant to this therapy and mediated by IL-6-dependnet PBs via producing a disease-specific autoantibody against aquaporin 4 (AQP4) on astrocyte.
Aquaporins: important but elusive drug targets.
Papadopoulos et al., San Francisco, United States. In Nat Rev Drug Discov, 2014
Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica.
Physiological roles of aquaporin-4 in brain.
Ottersen et al., In Physiol Rev, 2013
Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces.
Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study.
Wingerchuk et al., Rochester, United States. In Lancet Neurol, 2013
BACKGROUND: Complement activation after binding of an IgG autoantibody to aquaporin 4 (AQP4) is thought to be a major determinant of CNS inflammation and astrocytic injury in neuromyelitis optica.
Aquaporin water channels in the nervous system.
Verkman et al., London, United Kingdom. In Nat Rev Neurosci, 2013
AQP4 is the principal member of this protein family in the CNS, where it is expressed in astrocytes and is involved in water movement, cell migration and neuroexcitation.
Aquaporin-4 in the heart: expression, regulation and functional role in ischemia.
Vaage et al., Oslo, Norway. In Basic Res Cardiol, 2012
AQP4 mRNA expression is downregulated by hypoxia and ischemia.
Aggravated chronic brain injury after focal cerebral ischemia in aquaporin-4-deficient mice.
Wei et al., Hangzhou, China. In Neurosci Lett, 2012
AQP4 may be important in the chronic phase of the post-ischemic recovery process.
Aquaporin 4 and neuromyelitis optica.
Verkman et al., London, United Kingdom. In Lancet Neurol, 2012
[review] The evidence that AQP4-IgG is involved in the development of neuromyelitis optica has revolutionised our understanding of the disease, yet important unanswered questions remain.
An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment.
Fallier-Becker et al., Tübingen, Germany. In Plos One, 2011
primary rat or mouse astrocytes in culture did not lose their ability to express AQP4, and they were able to form few OAPs.
Differential expression of MMP-9 and AQP4 in human glioma samples.
Yuan et al., Beijing, China. In Folia Neuropathol, 2011
Our findings suggest differential expression patterns of MMP-9 and AQP4 in different grades of gliomas
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