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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: adiponectin, Insulin, Akt, APP, CAN
Papers on APPL1
Central Resistin/TLR4 impairs adiponectin signaling contributing to insulin and FGF21 resistance.
Taouis et al., Orsay, France. In Diabetes, Feb 2016
Here, we investigated whether central resistin promotes insulin resistance through the impairment of adiponectin and FGF21 signaling.We showed that chronic ICV resistin infusion down-regulated both hypothalamic and hepatic APPL1, a key protein in adiponectin signaling, associated with decreased Akt/APPL1 interaction and an increased Akt association with its endogenous inhibitor TRB3.
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.
Vanhaesebroeck et al., Toulouse, France. In Cell Rep, Jan 2016
This results in an expansion of the very early APPL1-positive endosomal compartment and altered insulin receptor trafficking, correlating with an amplification of insulin-induced, class I PI3K-dependent Akt signaling, without impacting MAPK activity.
Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis.
ZiWen et al., Chongqing, China. In J Diabetes Res, Dec 2015
We detected apoptosis rate by TUNEL, the adiponectin and high molecular weight adiponectin (HMW-adiponectin) by ELISA, and the expression of APPL1, p-AMPK/T-AMPK, PPARα, and NF-κB by immunohistochemistry and western blotting.
Loss of Polo ameliorates APP-induced Alzheimer's disease-like symptoms in Drosophila.
Xue et al., Shanghai, China. In Sci Rep, 2014
The amyloid precursor protein (APP) has been implicated in the pathogenesis of Alzheimer's disease (AD).
Association of APPL1 Gene Polymorphism with Non-Alcoholic Fatty Liver Disease Susceptibility in a Chinese Han Population.
Zhang et al., In Clin Lab, 2014
BACKGROUND: The adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) has been suggested to play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
Adiponectin signaling in the liver.
Marliss et al., Chapel Hill, United States. In Rev Endocr Metab Disord, 2014
This article reviews the adiponectin signaling pathway in the liver through T-cadherin, AdipoR1, AdipoR2, AMPK, ceramidase activity, APPL1 and the recently discovered Suppressor Of Glucose from Autophagy (SOGA).
Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin.
Xu et al., Hong Kong, Hong Kong. In Best Pract Res Clin Endocrinol Metab, 2014
Adiponectin and insulin signaling pathways converge at the adaptor protein APPL1.
Functional proteomics, human genetics and cancer biology of GIPC family members.
Katoh, Tokyo, Japan. In Exp Mol Med, 2012
The PDZ domain of GIPC1 is involved in interactions with transmembrane proteins [IGF1R, NTRK1, ADRB1, DRD2, TGFβR3 (transforming growth factorβ receptor type III), SDC4, SEMA4C, LRP1, NRP1, GLUT1, integrin α5 and VANGL2], cytosolic signaling regulators (APPL1 and RGS19) and viral proteins (HBc and HPV-18 E6).
Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway.
Luo et al., Hangzhou, China. In J Neurosci, 2012
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt cascade in neurons.
Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
Dong et al., San Antonio, United States. In J Biol Chem, 2012
APPL1 is a novel target in endoplasmic reticulum (ER) stress-induced insulin resistance and PKCalpha is the kinase mediating ER stress-induced phosphorylation of APPL1 at Ser(430).
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.
Xu et al., Hong Kong, Hong Kong. In Proc Natl Acad Sci U S A, 2012
Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin resistance to beta-cell dysfunction in type 2 diabetes.
The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.
Webb et al., Nashville, United States. In Mol Biol Cell, 2012
results demonstrate an important new function for APPL1 in regulating cell migration and adhesion turnover through a mechanism that depends on Src and Akt
Analysis of amyloid precursor protein function in Drosophila melanogaster.
Kretzschmar et al., Mainz, Germany. In Exp Brain Res, 2012
In contrast, invertebrates like Caenorhabditis elegans and Drosophila express only one APP-like protein but whereas a null mutation in the C. elegans APL-1 protein is lethal, flies lacking APPL (Amyloid Precursor Protein-like) are viable but show synaptic defects and behavioral abnormalities.
Genetic variability in adapter proteins with APPL1/2 is associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population.
Guo et al., Beijing, China. In Chin Med J (engl), 2011
Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population.
Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways.
Neumeier et al., Regensburg, Germany. In Febs Lett, 2010
Studies indicate that APPL1 has been recently identified as an AdipoR1 and AdipoR2 binding protein.
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
Xu et al., Hong Kong, Hong Kong. In Cell Metab, 2009
Overexpression of APPL1 protein in the liver of db/db obese mice suppressed the interaction between Proto-Oncogene Proteins c-akt and TRB3 protein.
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes.
De Camilli et al., New Haven, United States. In Cell, 2009
Using quantitative single vesicle imaging and acute manipulation of phosphoinositides we show that APPL endosomes, which participate in growth factor receptor trafficking and signaling, represent an early endocytic intermediate common to a subset of clathrin derived endocytic vesicles and macropinosomes.
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
Zerial et al., Dresden, Germany. In Cell, 2008
Here, we tested this hypothesis by investigating the role of the Rab5 effector Appl1, an endosomal protein that interacts with transmembrane receptors and Akt.
Substrate selectivity APPLies to Akt.
Guan et al., Shanghai, China. In Cell, 2008
In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
APPLied mechanics: uncovering how adiponectin modulates insulin action.
Kim et al., San Diego, United States. In Cell Metab, 2006
A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.
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