Central Resistin/TLR4 impairs adiponectin signaling contributing to insulin and FGF21 resistance.
Orsay, France. In Diabetes, Feb 2016
Here, we investigated whether central resistin promotes insulin resistance through the impairment of adiponectin and FGF21 signaling.We showed that chronic ICV resistin infusion down-regulated both hypothalamic and hepatic APPL1, a key protein in adiponectin signaling, associated with decreased Akt/APPL1 interaction and an increased Akt association with its endogenous inhibitor TRB3.
Adiponectin signaling in the liver.
Chapel Hill, United States. In Rev Endocr Metab Disord, 2014
This article reviews the adiponectin signaling pathway in the liver through T-cadherin, AdipoR1, AdipoR2, AMPK, ceramidase activity, APPL1 and the recently discovered Suppressor Of Glucose from Autophagy (SOGA).
Functional proteomics, human genetics and cancer biology of GIPC family members.
Tokyo, Japan. In Exp Mol Med, 2012
The PDZ domain of GIPC1 is involved in interactions with transmembrane proteins [IGF1R, NTRK1, ADRB1, DRD2, TGFβR3 (transforming growth factorβ receptor type III), SDC4, SEMA4C, LRP1, NRP1, GLUT1, integrin α5 and VANGL2], cytosolic signaling regulators (APPL1 and RGS19) and viral proteins (HBc and HPV-18 E6).
Analysis of amyloid precursor protein function in Drosophila melanogaster.
Mainz, Germany. In Exp Brain Res, 2012
In contrast, invertebrates like Caenorhabditis elegans and Drosophila express only one APP-like protein but whereas a null mutation in the C. elegans APL-1 protein is lethal, flies lacking APPL (Amyloid Precursor Protein-like) are viable but show synaptic defects and behavioral abnormalities.
Substrate selectivity APPLies to Akt.
Shanghai, China. In Cell, 2008
In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
APPLied mechanics: uncovering how adiponectin modulates insulin action.
San Diego, United States. In Cell Metab, 2006
A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.