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Apolipoprotein L, 6

Apolipoprotein l6, ApoL6
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: apolipoprotein L-I, bcl-2, PrP, LRP, p53
Papers on Apolipoprotein l6
Gene Expression in HIV-Associated Neurocognitive Disorders: A Meta-Analysis.
Archer et al., Richmond, United States. In J Acquir Immune Defic Syndr, Jan 2016
Strong examples of the highly upregulated genes were PSMB8-AS1, APOL6, TRIM69, PSME1, CTSB, HLA-E, GPNMB, UBE2L6, PSME2, NET1, CAPG, B2M, RPL38, GBP1, and PLSCR1.
Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.
Telenti et al., Lausanne, Switzerland. In Retrovirology, 2014
Five factors (APOL1, APOL6, CD164, TNFRSF10A, TNFRSF10D) suppressed infectious HIV-1 production in transfected 293T cells by >90% and six additional candidates (FCGR3A, CD3E, OAS1, GBP5, SPN, IFI16) achieved this when the virus was lacking intact accessory vpr, vpu and nef genes.
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication.
Michiels et al., Brussels, Belgium. In Plos One, 2014
In contrast to human ApoL6, ApoL9 did not sensitize cells to apoptosis, in spite of the presence of a conserved putative BH3 domain, required for antiviral activity.
Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.
Muñoz-Pinedo et al., Barcelona, Spain. In Cell Death Dis, 2013
Apolipoprotein L1 and apolipoprotein L6 have been recently described as novel pro-death BH3-only proteins that are also capable of regulating autophagy.
Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
Kovar et al., Vienna, Austria. In Br J Cancer, 2013
Comparative transcriptome analysis on the three cell lines established from the same patient identified differential expression levels of several TP53 and apoptosis-associated genes such as APOL6, PENK, PCDH7 and MST4 in the APR-246-sensitive cell line relative to the less APR-246-sensitive cell lines.
Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome.
Zhou et al., Nanjing, China. In Gene, 2013
for GA/AA, P=0.023, compared with GG), rs5999924 (adjusted OR=1.22 for AT/TT, P=0.038, compared with AA) in the APOL6 3'UTR were identified to correlate with MetS in the total sample and females.
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells.
Hu et al., Albuquerque, United States. In J Biol Chem, 2011
results suggest that ApoL6 regulates both apoptosis and autophagy in SMCs. IFNgamma-initiated, ApoL6-induced apoptosis in vascular cells may be an important factor causing plaque instability
The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions.
Malik et al., Seattle, United States. In Genome Res, 2009
APOL6, furthermore, shows evidence of an adaptive sweep during recent human evolution.
Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells.
Hu et al., Albuquerque, United States. In Mol Cancer Res, 2005
Apolipoprotein l6 is a novel proapoptotic Bcl-2 homology 3-only protein that induces mitochondria-mediated apoptosis in cancer cells
The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.
Lowry et al., Reading, United Kingdom. In Genomics, 2001
APOL6 has been found only in humans
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