GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Apolipoprotein D
apolipoprotein D, apoD
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008] (from
NCBI)
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Top mentioned proteins:
lipocalin, ACID, Apo, CAN, HAD
Papers using
apolipoprotein D
antibodies
Prophylactic activation of neuroprotective stress response pathways by dietary and behavioural manipulations NeuroRx*
Supplier
In PLoS ONE, 2003
... homolog of Apolipoprotein D leads to increased stress resistance and extended lifespan.
Papers on
apolipoprotein D
Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma.
New
Rio de Janeiro, Brazil. In Urol Oncol, Jan 2016
Proteins such as kininogen-1, uromodulin, apolipoprotein D, polyubiquitin, and CD59 glycoprotein were down secreted according to the groups CG>GP>PP.
Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study.
New
Maywood, United States. In Clin Neurol Neurosurg, Jan 2016
ApoE, ApoD, synaptic nuclear envelope protein 1, clusterin, α-1-acid glycoprotein, plasma protease C1 inhibitor, and prostaglandin H2 D isomerase were downregulated in patients who developed CV post aSAH.
Proteomic analysis of HDL from inbred mice strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway.
New
Washington, D.C., United States. In J Lipid Res, Jan 2016
In contrast, ABCA1-specific cholesterol efflux correlated strongly with HDL's content of APOA1, APOC3 and APOD, but not RBP4 and PLTP.
Transcriptomic Signatures Mirror the Lack of the Fecundity/Longevity Trade-Off in Ant Queens.
New
Regensburg, Germany. In Mol Biol Evol, Dec 2015
We found 21 genes, including the putative aging candidate NLaz (an insect homolog of APOD), which were consistently more highly expressed in short-lived, unmated queens than in long-lived, mated queens.
Human plasma protein N-glycosylation.
New
Leiden, Netherlands. In Glycoconj J, Dec 2015
Thus, as the assessment of protein glycosylation is becoming a major element in clinical and biopharmaceutical research, this review aims to convey the current state of knowledge on the N-glycosylation of the major plasma glycoproteins alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein, alpha-2-macroglobulin, antithrombin-III, apolipoprotein B-100, apolipoprotein D, apolipoprotein F, beta-2-glycoprotein 1, ceruloplasmin, fibrinogen, immunoglobulin (Ig) A, IgG, IgM, haptoglobin, hemopexin, histidine-rich glycoprotein, kininogen-1, serotransferrin, vitronectin, and zinc-alpha-2-glycoprotein. In addition, the less abundant immunoglobulins D and E are included because of their major relevance in immunology and biopharmaceutical research.
Highly abundant defense proteins in human sweat as revealed by targeted proteomics and label-free quantification mass spectrometry.
New
Debrecen, Hungary. In J Eur Acad Dermatol Venereol, Oct 2015
It was shown that dermcidin is the most abundant sweat protein, and along with apolipoprotein D, clusterin, prolactin-inducible protein and serum albumin, they make up 91% of secreted sweat proteins.
Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.
Hannover, Germany. In Plos One, 2014
In contrast, ApoD expression did not support production of infectious HCV.
Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain.
Review
Bolzano - Bozen, Italy. In Neurobiol Aging, 2014
Apolipoprotein D (ApoD) is an ancient member of the lipocalin family with a high degree of sequence conservation from insects to mammals.
The composition and metabolism of large and small LDL.
Review
Boston, United States. In Curr Opin Lipidol, 2014
Proteins associated with LDL, in addition to apolipoprotein (apo) B, include the C apolipoproteins, apoA-I, apoA-IV, apoD, apoE, apoF, apoH, apoJ, apoL-1, apoM, α-1 antitrypsin, migration inhibitory factor-related protein 8, lysosome C, prenylcysteine oxidase 1, paraoxonase 1, transthyretin, serum amyloid A4, and fibrinogen α chain.
Clinical and molecular aspects of androgen insensitivity.
Review
Lübeck, Germany. In Endocr Dev, 2012
Only one regulated gene APOD has currently been identified to serve as a clinical tool for the diagnosis of androgen insensitivity.
Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia.
GeneRIF
Cadiz, Spain. In Metabolism, 2011
The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia.
Amyloid-β25-35 induces apolipoprotein D Synthesis and growth arrest in HT22 hippocampal cells.
GeneRIF
Oviedo, Spain. In J Alzheimers Dis, 2011
Abeta25-35 induces neuroprotective ApoD expression in hippocampal cells in response to stress-induced growth arrest.
Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93.
GeneRIF
Wollongong, Australia. In Plos One, 2011
Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions show the mechanism for selective oxidation of Met-93
Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems.
GeneRIF
Valladolid, Spain. In Glia, 2011
The data of this study supported that ApoD contributes to the endurance of astrocytes and decreases their reactivity level in vitro and in vivo
Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
GeneRIF
Augusta, United States. In Am J Physiol Heart Circ Physiol, 2011
Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch3 signaling.
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis.
Review
Washington, D.C., United States. In Methods Mol Biol, 2006
Four genes encoding ribosomal proteins (RPS2, RPS8, RPS18, RPL37A) were upregulated, and five genes (APOD, SORL1, SPOCK2, PRSS11, ID3) were downregulated in high-grade by all tests.
Emerging concepts of apolipoprotein D with possible implications for breast cancer.
Review
Bergen, Norway. In Cell Oncol, 2006
Apolipoprotein D (ApoD) is a small glycoprotein of 24 kD, and a member of the lipocalin family.
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Impact
Nashville, United States. In Cancer Cell, 2005
Microarray analysis identified MMP-7, cathepsin-K, and apolipoprotein D as being upregulated at the tumor-bone interface.
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.
Impact
Baltimore, United States. In Cancer Cell, 2002
Potent growth suppressive activity of three genes including CRIP-1, Apolipoprotein D, and Neuromedin U in ESCC cells was demonstrated by colony focus assays.
Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid.
Impact
In N Engl J Med, 1987
In cerebrospinal fluid from untreated patients with cerebrotendinous xanthomatosis, immunoreactive apolipoprotein B or apolipoprotein B fragment was increased about 100-fold and albumin about 3.5-fold; apolipoprotein AI, apolipoprotein D, and lecithin:cholesterol acyltransferase were 1.5 to 3 times more concentrated.
