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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

APOBEC3, Rfv-3
Top mentioned proteins: APOBEC3G, CAN, APOBEC-1, APOBEC3A, Ubiquitin
Papers on APOBEC3
The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.
Harris et al., Minneapolis, United States. In Cell Rep, Jan 2016
APOBEC3 family DNA cytosine deaminases provide overlapping defenses against pathogen infections.
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Chen et al., Shanghai, China. In Discov Med, Dec 2015
UNLABELLED: The relationship between members of APOBEC3 in tumor tissues and hepatocellular carcinoma prognosis was not well studied.
Rapid Determination of HIV-1 Mutant Frequencies and Mutation Spectra Using an mCherry/EGFP Dual-Reporter Viral Vector.
Mansky et al., Minneapolis, United States. In Methods Mol Biol, Dec 2015
The reporter-based method can be used to efficiently quantify changes in mutant frequencies and mutation spectra that arise due to a variety of factors, including viral mutagens, drug resistance mutations, cellular physiology, and APOBEC3 proteins.
Movements of HIV-1 genomic RNA-APOBEC3F complexes and PKR reveal cytoplasmic and nuclear PKR defenses and HIV-1 evasion strategies.
Kabat et al., Portland, United States. In Virus Res, Dec 2015
UNASSIGNED: APOBEC3 cytidine deaminases and viral genomic RNA (gRNA) occur in virions, polysomes, and cytoplasmic granules, but have not been tracked together.
APOBEC3 Proteins in Viral Immunity.
Ross et al., Philadelphia, United States. In J Immunol, Dec 2015
Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
The Role of the Single Deaminase Domain APOBEC3A in Virus Restriction, Retrotransposition, DNA Damage and Cancer.
Stephens et al., Denver, United States. In J Gen Virol, Nov 2015
UNASSIGNED: The apolipoprotein mRNA editing catalytic peptide 3 (APOBEC3; A3) proteins are a family of seven are cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) that restrict certain viral infections.
Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis.
Harris et al., Minneapolis, United States. In Sci Adv, Sep 2015
The APOBEC3 family of DNA cytosine deaminases is an integral part of these defenses.
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.
Harris et al., London, United Kingdom. In Cancer Discov, Jul 2015
Deregulation of APOBEC3 enzymes causes a general mutator phenotype that manifests as diverse and heterogeneous tumor subclones.
APOBEC3 Interference during Replication of Viral Genomes.
Gillet et al., Liège, Belgium. In Viruses, Jun 2015
In this review, we describe the mechanisms of APOBEC3 editing during viral replication, the viral strategies that prevent APOBEC3 activity and the consequences of APOBEC3 modulation on viral fitness and host genome integrity.
Intrinsic host restrictions to HIV-1 and mechanisms of viral escape.
Landau et al., New York City, United States. In Nat Immunol, Jun 2015
This Review discusses the biology of the restriction factors APOBEC3, SAMHD1 and tetherin and the viral accessory proteins that counteract them.
Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes.
Alian et al., Haifa, Israel. In Sci Rep, 2014
The strong association of APOBEC3 cytidine deaminases with somatic mutations leading to cancers accentuates the importance of their tight intracellular regulation to minimize cellular transformations.
Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Protzer et al., München, Germany. In Science, 2014
Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein.
Williams et al., Boston, United States. In Nat Chem, 2014
The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and retrotransposons.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
Malim et al., London, United Kingdom. In Nature, 2013
For the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely expressed restriction factors, such as APOBEC3 proteins, TRIM5-α, BST2 (refs 4, 5) and SAMHD1 (refs 6, 7), as well as additional factors that are stimulated by type 1 interferon (IFN).
Intrinsic cellular defenses against human immunodeficiency viruses.
Bieniasz et al., New York City, United States. In Immunity, 2012
Among these are several classes of proteins (APOBEC3, TRIM5, Tetherin, and SAMHD1) that inhibit the replication of human and simian immunodeficiency viruses.
Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.
Patterson et al., Bethesda, United States. In J Mol Biol, 2012
It was found that rat APOBEC-1 overexpression had a hypermutation pattern similar to that of APOBEC-3s on its substrate apolipoprotein B mRNA.
Studies on the restriction of murine leukemia viruses by mouse APOBEC3.
Rein et al., Frederick, United States. In Plos One, 2011
restriction of murine leukemia viruses by mouse APOBEC3
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.
Hung et al., Houston, United States. In J Clin Invest, 2011
novel mechanism in which APOBEC3G promotes colorectal cancer hepatic metastasis through inhibition of miR-29-mediated suppression of MMP2
Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.
Santiago et al., Aurora, United States. In Plos Pathog, 2011
Apobec3 promotes the release of substantial levels of noninfectious virions in the plasma during acute Friend virus infection.
Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.
Harris et al., Minneapolis, United States. In J Biol Chem, 2011
Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein
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