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Chromosome 9 open reading frame 3

This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: HDL, CAN, HAD, AGE, fibrillin-1
Papers using Apo antibodies
Intercellular transport of epidermis-expressed MADS domain transcription factors and their effect on plant morphology and oral transition.
Jönsson Henrik, In PLoS ONE, 2009
... of the living plant tissue was performed with a Leica SPE DM5500 upright microscope with a ACS APO 40×/1.15
Anterior-posterior positional information in the absence of a strong Bicoid gradient.
Desplan Claude, In PLoS Biology, 2008
... For high resolution imaging, we used a 100× HCX PL APO CS NA 1.46 oil immersion objective on a Leica SP5 laser-scanning confocal microscope ...
TCam-2 but not JKT-1 cells resemble seminoma in cell culture
Guillot Pascale V et al., In Molecular Therapy, 2007
... Images were collected on a confocal laser-scanning microscope Leica TCS SP5 (X1000 PL APO oil objective ; Leica, Wetzlar, Germany) and transferred ...
Single-spike detection in vitro and in vivo with a genetic Ca(2+) sensor.
Mansvelder Huibert D., In PLoS ONE, 2007
... All images were acquired with a 63x water immersion objective (HCX APO, 63×, NA 0.9, Leica, Germany) ...
Apoptotic related biochemical changes in human amnion cells induced by tributyltin
Jiang Guibin et al., In Environmental Health Perspectives, 2006
... The Apo-Direct Kit was from BD Biosciences Pharmingen (San Jose, CA, ...
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Papers on Apo
Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits.
Pérez-Méndez et al., Mexico. In Lipids, Feb 2016
The catabolic rate of HDL-apo A-I was evaluated by exogenous radiolabelling with iodine-131.
High-sensitivity C-reactive protein, apolipoproteins, and residual diuresis in chronic kidney disease patients undergoing hemodialysis.
Filho et al., Uberlândia, Brazil. In Clin Exp Nephrol, Feb 2016
Serum high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein (Apo) A1 and B levels were measured after fasting for 12 h.
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11.
Burke et al., Victoria, Canada. In Protein Sci, Feb 2016
Structures of PI4KIIIβ in an Apo state and bound to the potent inhibitor BQR695 in complex with both GTPγS and GDP loaded Rab11 were determined.
Reverse overshot water-wheel retroendocytosis of Apo Transferrin extrudes cellular iron.
Raje et al., Chandīgarh, India. In J Cell Sci, Feb 2016
Utilizing primary cells and cell lines (including those with no discernible expression of ferroportin on their surface) we demonstrate that upon iron loading the multifunctional enzyme Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) that is recruited to the cell surface treadmills apo transferrin (apo Tf) in and out of the cell.
Lp(a) Measurements for Clinical Application.
Albers et al., Washington, D.C., United States. In J Lipid Res, Jan 2016
UNASSIGNED: The high degree of size heterogeneity of apolipoprotein(a) [apo(a)], the distinct protein component of lipoprotein(a) [Lp(a)], renders more difficult the development and selection of specific antibodies directed to apo(a) and poses significant challenges to the development of immunoassays to measure its concentration in plasma or serum samples.
High-Density Lipoprotein-Targeted Therapy and Apolipoprotein A-I Mimetic Peptides.
Saku et al., Fukuoka, Japan. In Circ J, Dec 2015
HDL therapies using reconstituted HDL, including apolipoprotein (Apo) A-I Milano, ApoA-I mimetics, or full-length ApoA-I, are dramatically effective in animal models.
Antisense Inhibition of Apolipoprotein(a) to Lower Plasma Lipoprotein(a) Levels in Humans.
Tsimikas et al., United States. In J Lipid Res, Dec 2015
Recent animal and human studies have shown that Lp(a) can be specifically targeted with second generation antisense oligonucleotides (ASOs) that inhibit apo(a) mRNA translation.
Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review.
Nanda et al., Shreveport, United States. In Neurosurg Focus, Nov 2015
Apolipoprotein E (Apo-E), a key player in lipid metabolism, is recognized as one of the most powerful genetic risk factors for dementia and other neurodegenerative diseases.
Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: experimental animal models and clinical evidence.
Ruscica et al., Padova, Italy. In Transl Res, Nov 2015
In mice, PCSK9 regulates the HDL cholesterol (HDL-C) levels by the degradation of hepatic LDLR, thus inhibiting the uptake of apolipoprotein (Apo)E-containing HDLs.
Overexpression of an endo-1,4-β-glucanase V gene (EGV) from Trichoderma reesei leads to the accumulation of cellulase activity in transgenic rice.
Ma et al., Hefei, China. In Genet Mol Res, 2014
In this study, we isolated an endo-1,4-beta-glucanase gene (EGV) from Trichoderma reesei and inserted this gene downstream of a fragment encoding the signal peptide Apo-SP in a modified pCAMBIA1301 vector to obtain an Apo-SP and AsRed fusion protein.
CD95 promotes tumour growth.
Peter et al., Chicago, United States. In Nature, 2010
CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis.
XIAP discriminates between type I and type II FAS-induced apoptosis.
Kaufmann et al., Melbourne, Australia. In Nature, 2009
FAS (also called APO-1 and CD95) and its physiological ligand, FASL, regulate apoptosis of unwanted or dangerous cells, functioning as a guardian against autoimmunity and cancer development.
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Chang et al., Los Angeles, United States. In Science, 2009
The x-ray structure of apo P-gp at 3.8 angstroms reveals an internal cavity of approximately 6000 angstroms cubed with a 30 angstrom separation of the two nucleotide-binding domains.
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization.
Schneider-Brachert et al., Kiel, Germany. In Nat Rev Mol Cell Biol, 2008
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis.
Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology.
Forrester et al., Edinburgh, United Kingdom. In J Cell Biochem, 2008
Alternative splicing predictably produces protein products with or without the catalytic domain and/or a nucleolar localisation signal and represents mechanism in regulating activity of APO.
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity.
Chervonsky et al., Bar Harbor, United States. In Immunity, 2007
Fas (also known as Apo-1 and CD95) receptor has been suggested to control T cell expansion by triggering T cell-autonomous apoptosis.
Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.
López-Otín et al., Oviedo, Spain. In J Biol Chem, 2005
Data suggest that aminopeptidase O could play a role in the proteolytic processing of bioactive peptides in those tissues where it is expressed.
More papers using Apo antibodies
Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore.
Blanke Steven R., In PLoS Pathogens, 2004
... Pictures were acquired on a TCS SP2 confocal microscope (Leica) equipped with a 63× HCX PL APO, NA = 1.40 objective (Leica), under oil immersion ...
Cdk2 as a master of S phase entry: fact or fake?
Li Bin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Apo-BrdU apoptosis detection kit and mitochondrial membrane potential detection kit were purchased from BD Biosciences (San Diego, CA, USA) ...
Flexible structure alignment by chaining aligned fragment pairs allowing twists.
Livesay Dennis R., In PLoS Computational Biology, 2002
... The Apo and ATP simulations were carried our respectively by removing the ligand and by modeling ATP in the binding site according to crystal data ...
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice
Oliveira Helena CF et al., In Lipids in Health and Disease, 2002
... Apo CIII transgenic mice were screened by ...
Direct membrane protein–DNA interactions required early in nuclear envelope assembly
Mattaj Iain W. et al., In The Journal of Cell Biology, 1996
... analyzed at room temperature on a confocal microscope (TCS SP2; Leica) using a 40× objective (HCX PL APO CS; Leica), NA 1.25, immersion oil, ...
Performance of diagnostic systems in occlusal caries detection compared
Heinzel-Gutenbrunner Monika et al., In International Journal of Dentistry, 1993
... The occlusal surfaces were photographed digitally (Leica Zoomsystem Z6 APO/QWin Standard V 3.4.0
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