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Ornithine decarboxylase antizyme 1

Antizyme, OAZ, OAZ1, AZ1, antizyme 1, Antizyme inhibitor
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ornithine decarboxylase, CAN, ACID, Ubiquitin, HAD
Papers using Antizyme antibodies
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Atkins John F. et al., In Nucleic Acids Research, 2004
... Antizyme overexpression in transgenic mice reduces cell proliferation, ...
Papers on Antizyme
Engineering degrons of yeast ornithine decarboxylase as vehicles for efficient targeted protein degradation.
Ratna Prabha et al., Vadodara, India. In Biochim Biophys Acta, Dec 2015
BACKGROUND: Ornithine decarboxylase (ODC), which catalyzes the first step of polyamine biosynthesis, undergoes rapid targeted degradation (TPD) with the help of its two degron sequences, namely the N-terminal 50 residues (N50) and α/β domain (α/β) housing antizyme binding element (AzBE), in response to increased polyamine levels.
Structural basis of antizyme-mediated regulation of polyamine homeostasis.
Chan et al., Taipei, Taiwan. In Proc Natl Acad Sci U S A, Oct 2015
To maintain polyamine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN).
Involvement of Antizyme Characterized from the Small Abalone Haliotis diversicolor in Gonadal Development.
Ke et al., Haikou, China. In Plos One, 2014
Ornithine decarboxylase (ODC) and antizyme (AZ) are essential elements of a feedback circuit that regulates cellular polyamines.
The Orthology Clause in the Next Generation Sequencing Era: Novel Reference Genes Identified by RNA-seq in Humans Improve Normalization of Neonatal Equine Ovary RT-qPCR Data.
Steinborn et al., Vienna, Austria. In Plos One, 2014
The expression stability of eleven novel RGs (C1orf43, CHMP2A, EMC7, GPI, PSMB2, PSMB4, RAB7A, REEP5, SNRPD3, VCP and VPS29) was assessed by RT-qPCR in ovaries of seven neonatal fillies and compared to that of the expressed repetitive element ERE-B, two universal (OAZ1 and RPS29) and four traditional RGs (ACTB, GAPDH, UBB and B2M).
Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1.
Song et al., Shanghai, China. In Sci Rep, 2014
To maintain normal cellular proliferation, regulation of polyamine synthesis is imposed by Antizyme1 (AZ1).
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
Hildebrandt et al., Ann Arbor, United States. In Cell, 2012
Study identifies by whole-exome resequencing, mutations of MRE11, ZNF423, and CEP164 as causing Nephronophthisis-related ciliopathies.
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Spiegelman et al., Boston, United States. In Cell Metab, 2012
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity.
Johnson et al., Memphis, United States. In J Biol Chem, 2012
In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 is activated, leading to the inhibition of global protein synthesis and increased AZ1 synthesis via a cap-independent mechanism.
Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.
Zetter et al., Boston, United States. In Mol Cancer Res, 2011
Antizyme and its endogenous antizyme inhibitor have recently emerged as prominent regulators of cell growth, transformation, centrosome duplication, and tumorigenesis.
Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA.
Dohmen et al., Köln, Germany. In Nature, 2011
Whereas mammals express several antizyme genes, we have identified a single orthologue, termed OAZ1, in Saccharomyces cerevisiae.
The influence of corticosterone on antizyme gene expression in early regenerating rat liver.
Li et al., Xinxiang, China. In Acta Gastroenterol Belg, 2011
Corticosterone treatment induces antizyme 1 protein synthesis in early regenerating rat liver. However, it has little effect on antizyme 1 gene transcription.
Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor.
Hung et al., T'ai-chung-shih, Taiwan. In Plos One, 2010
AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function.
[Identification of novel molecules regulating differentiation and hormone secretion and clarification of their functional mechanisms in pancreatic endocrine cells].
Suzuki et al., Musashino, Japan. In Yakugaku Zasshi, 2010
Antizyme, which binds to ornithine decarboxylase (ODC) and thereby reduces the cellular polyamine level, was found to be necessary for conversion of ASPC-1 cells, a pancreatic ductal tumor cell line, into alpha-cells forming the islet-like structure and expressing glucagon gene.
Antizyme inhibitor 2: molecular, cellular and physiological aspects.
Peñafiel et al., Murcia, Spain. In Amino Acids, 2010
There are two antizyme inhibitors (AZIN), known as AZIN1 and AZIN2, that bind to AZs and negate their effects on polyamine metabolism.
Saliva as a tool for oral cancer diagnosis and prognosis.
Nagler, Haifa, Israel. In Oral Oncol, 2009
In recent years, significant alterations have been demonstrated in the saliva of oral cancer patients in the epithelial tumor markers--Cyfra 21-1, TPS and CA12, various oxidative stress-related salivary parameters as ROS and RNS, biochemical and immunological parameters as IGF and MMP's and RNA transcripts of IL8, IL-1B, DUSP1, HA3, OAZ1, S100P, and SAT.
Antizyme and antizyme inhibitor, a regulatory tango.
Kahana, Israel. In Cell Mol Life Sci, 2009
An inactive ODC-related protein termed antizyme inhibitor regulates polyamine metabolism by negating antizyme functions.
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
Bernards et al., Amsterdam, Netherlands. In Cancer Cell, 2009
Low ZNF423 expression is associated with neuroblastoma.
Epigenetic control of polyamines by the prion [PSI+].
Rousset et al., Orsay, France. In Nat Cell Biol, 2008
Here, we show that [PSI+] enhances expression of antizyme, a negative regulator of cellular polyamines, by modulating the +1 frameshifting required for its expression.
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
Massagué et al., New York City, United States. In Cell, 2000
We have identified the 30-zinc finger protein OAZ as a DNA-binding factor that associates with Smads in response to BMP2, forming a complex that transcriptionally activates the homeobox regulator of Xenopus mesoderm and neural development, Xvent-2.
Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.
Hayashi et al., Salt Lake City, United States. In Cell, 1995
antizyme expression requires programmed, ribosomal frameshifting
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