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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Angiopoietin 1

Angpt1, angiopoietin-1, angiopoietin
Top mentioned proteins: vascular endothelial growth factor, TIE-2, HAD, CAN, V1a
Papers on Angpt1
Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function.
Boer et al., Amsterdam, Netherlands. In Br J Anaesth, Feb 2016
RESULTS: Cardiopulmonary bypass was associated with increased P-selectin, vascular cell adhesion molecule-1, and von Willebrand factor plasma concentrations and an increase in the angiopoietin-2 to angiopoietin-1 ratio, irrespective of the flow profile.
Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular Cells.
Morishita et al., Suita, Japan. In Arterioscler Thromb Vasc Biol, Feb 2016
Administration of cilostazol significantly increased the expression of hepatocyte growth factor (HGF), vascular endothelial growth factor, angiopoietin-1, and peroxisome proliferator-activated receptor-γ in vasculature.
Subretinal AAV2.COMP-Ang1 Suppresses Choroidal Neovascularization and Vascular Endothelial Growth Factor in a Murine Model of Age-Related Macular Degeneration.
Ambati et al., Salt Lake City, United States. In Exp Eye Res, Feb 2016
UNASSIGNED: To assess whether Tie2-mediated vascular stabilization ameliorates neovascular age-related macular degeneration (AMD), we investigated the impact of adeno-associated virus-mediated gene therapy with cartilage oligomeric matrix protein angiopoietin-1 (AAV2.COMP-Ang1) on choroidal neovascularization (CNV), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor (HIF) in a mouse model of the disease.
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Sun et al., Harbin, China. In J Vasc Surg, Feb 2016
In exploration of the mechanisms, we found that IAC increased the release of angiopoietin 2 (Ang2) and its expression in lung tissues.
Circulating angiopoietin-1 and -2 in patients with stable and exacerbated asthma.
Jang et al., Puch'ŏn, South Korea. In Ann Allergy Asthma Immunol, Feb 2016
BACKGROUND: Angiopoietin (Ang)-1 and -2 are involved in the pathogenesis of asthma and have been identified as markers of asthma severity.
Non-statin Treatments for Managing LDL Cholesterol and Their Outcomes.
Stein et al., Cincinnati, United States. In Clin Ther, Jan 2016
Additional agents are being developed as orphan indications expressly for patients with homozygous familial hypercholesterolemia, including peroxisome proliferator activated receptor-δ agonists, angiopoietin-like protein 3 inhibitors, and gene therapy.
Novel therapeutics in hypertriglyceridemia.
Hegele et al., London, Canada. In Curr Opin Lipidol, Dec 2015
Other potential therapies include small molecule inhibitors of microsomal triglyceride transfer protein (lomitapide) and diacylglycerol acyltransferase-1 (pradigastat), and a monoclonal antibody against angiopoietin-like protein 3 (REGN1500).
Ocular Angiogenesis: Vascular Endothelial Growth Factor and Other Factors.
Adamis et al., In Dev Ophthalmol, Dec 2015
Additional proangiogenic targets that have emerged as potential mediators of ocular neovascularization include hypoxia-inducible factor-1, angiopoietin-2, platelet-derived growth factor-B and components of the alternative complement pathway.
Gene-based therapies in lipidology: current status and future challenges.
Brisson et al., Montréal, Canada. In Curr Opin Lipidol, Dec 2015
Most advanced antisense oligonucleotide drugs target apolipoprotein C-III, apolipoprotein (a), angiopoietin-like 3, and diacylglycerol o-acyltransferase-2.
Update on the molecular biology of dyslipidemias.
Ramasamy, Worcester, United Kingdom. In Clin Chim Acta, Dec 2015
Mutations in the genes APOB, and ANGPTL3 and ANGPTL4 (that encode angiopoietin-like proteins which inhibit lipoprotein lipase activity) can further cause low levels of apoB containing lipoproteins.
Trebananib (AMG 386) in Combination With Sunitinib in Patients With Metastatic Renal Cell Cancer: An Open-Label, Multicenter, Phase II Study.
Ravaud et al., Bordeaux, France. In J Clin Oncol, Nov 2015
PURPOSE: Trebananib, an investigational recombinant peptide-Fc fusion protein, neutralizes the receptor-ligand interaction between Tie2 and angiopoietin-1/2.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.
Augustin et al., Heidelberg, Germany. In Cancer Cell, 2015
Antiangiogenic tumor therapy has failed in the adjuvant setting.
ANGPTL8/betatrophin does not control pancreatic beta cell expansion.
Gromada et al., United States. In Cell, 2014
Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation.
Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial.
Oza et al., Phoenix, United States. In Lancet Oncol, 2014
BACKGROUND: Angiogenesis is a valid target in the treatment of epithelial ovarian cancer.
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