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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

STAM binding protein

AMSH, associated molecule with the SH3 domain of STAM
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Stam, CAN, UBPY, proopiomelanocortin
Papers using AMSH antibodies
AMSH is an endosome-associated ubiquitin isopeptidase
Urbé Sylvie et al., In The Journal of Cell Biology, 2001
... Human AMSH cDNA was purchased from Origene Technologies Inc., sequenced and ...
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc
Sugamura Kazuo et al., In The Journal of Experimental Medicine, 1997
... The bait plasmid was constructed by insertion of a cDNA fragment encoding the full-length human AMSH protein (our unpublished protocol) in pAS2-1 (Clontech ...
Papers on AMSH
The VHS Domain of Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.
Wiener et al., Israel. In J Biol Chem, Dec 2015
UNASSIGNED: The deubiquitinating enzyme Associated molecule with the SH3 domain of STAM (AMSH) is crucial for the removal of ubiquitin molecules during receptor mediated endocytosis and lysosomal receptor sorting.
Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.
Das et al., West Lafayette, United States. In Biochemistry, Nov 2015
The endosome-associated deubiquitinase (DUB) AMSH is a member of the JAMM family of zinc-dependent metallo isopeptidases with high selectivity for Lys63-linked polyubiquitin chains, which play a key role in endosomal-lysosomal sorting of activated cell surface receptors.
Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3.
Isono et al., Freising, Germany. In Proc Natl Acad Sci U S A, Nov 2015
Associated molecule with the SH3 domain of signal transduction adaptor molecule (STAM) (AMSH) is a conserved metalloprotease DUB in eukaryotes.
Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes.
Ling et al., Jinan, China. In Biochemistry, Sep 2015
The human AMSH-LP DUB domain specifically cleaves the isopeptide bonds in the Lys63-linked polyubiquitin chains.
Synovial Fluid α-MSH Levels are Inversely Correlated with Articular Cartilage Degeneration in Anterior Cruciate Ligament Deficient Knees.
Tian et al., In Clin Lab, 2014
Supplementing with a-MSH may serve as a possible adjuvant therapy for delaying cartilage degeneration after ACL injury.
AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions.
Girão et al., Coimbra, Portugal. In Faseb J, 2014
Here we report that the DUB-associated molecule with the SH3 domain of STAM (AMSH) interacts with Cx43 and mediates its deubiquitination.
Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.
Das et al., West Lafayette, United States. In Biochemistry, 2014
AMSH, a conserved zinc metallo deubiquitinase, controls downregulation and degradation of cell-surface receptors mediated by the endosomal sorting complexes required for transport (ESCRT) machinery.
Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins.
Echalier et al., Montpellier, France. In Curr Protein Pept Sci, 2013
Examples of MPN domaincontaining proteins that are not incorporated in a large multi-protein complex have also been reported and include AMSH (for associated molecule with the SH3 domain of STAM) and the AMSH-Like Protein (AMSH-LP).
Mechanism of recruitment and activation of the endosome-associated deubiquitinase AMSH.
Das et al., West Lafayette, United States. In Biochemistry, 2013
AMSH, a deubiquitinating enzyme (DUB) with exquisite specificity for Lys63-linked polyubiquitin chains, is an endosome-associated DUB that regulates sorting of activated cell-surface signaling receptors to the lysosome, a process mediated by the members of the endosomal sorting complexes required for transport (ESCRT) machinery.
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome.
Boycott et al., Ottawa, Canada. In Nat Genet, 2013
We used whole-exome sequencing of five patients with MIC-CAP syndrome and identified recessive mutations in STAMBP, a gene encoding the deubiquitinating (DUB) isopeptidase STAMBP (STAM-binding protein, also known as AMSH, associated molecule with the SH3 domain of STAM) that has a key role in cell surface receptor-mediated endocytosis and sorting.
Root proteases: reinforced links between nitrogen uptake and mobilization and drought tolerance.
Raorane et al., Manila, Philippines. In Physiol Plant, 2012
Drought-induced proteases in rice roots, as known from rice expression databases, are discussed for future research on certain M50, Deg, FtsH, AMSH and deubiquitination proteases.
Structural basis for ESCRT-III CHMP3 recruitment of AMSH.
Weissenhorn et al., Grenoble, France. In Structure, 2011
tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III
Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination.
Nash et al., Chicago, United States. In Cell Biochem Biophys, 2011
Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins.
AMSH is required to degrade ubiquitinated proteins in the central nervous system.
Tanaka et al., Sendai, Japan. In Biochem Biophys Res Commun, 2011
These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate receptors in vivo
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
Nash et al., Chicago, United States. In J Biol Chem, 2010
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.
Bunnett et al., San Francisco, United States. In J Biol Chem, 2009
Data suggest that AMSH and UBPY are essential for trafficking and down-regulation of PAR(2) but not for regulating PAR(2) dissociation from beta-arrestin2 or PAR(2)-mediated ERK2 activation.
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains.
Fukai et al., Tokyo, Japan. In Nature, 2008
crystal structures of the human AMSH-LP DUB domain alone and in complex with a Lys 63-linked di-ubiquitin at 1.2 A and 1.6 A resolutions, respectively
Neuropeptide Y and alpha-melanocyte-stimulating hormone: interaction in obesity and possible role in the development of hypertension.
Zamboulis et al., Thessaloníki, Greece. In Int J Clin Pract, 2008
More specifically, leptin, neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone (a-MSH) appear to be implicated in the pathogenesis of obesity and also contribute to the development of hypertension in obesity.
Controlling receptor downregulation by ubiquitination and deubiquitination.
Komada, Yokohama, Japan. In Curr Drug Discov Technol, 2008
UBPY and AMSH in mammals, as well as Doa4 in yeast, are deubiquitinating enzymes (DUBs) that associate with class E Vps proteins on endosomes.
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