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Amphiphysin, amphiphysin I, amphiphysin 1
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: beta 2-adrenoceptor, Actin, Dynamin I, CAN, Src
Papers on Amphiphysin
Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.
Becker et al., Bonn, Germany. In Neurobiol Dis, Feb 2016
In a subsequent promoter analysis, we found the single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus.
Yeast Ivy1p is a putative I-BAR-domain protein with pH-sensitive filament forming ability in vitro.
Suetsugu et al., Tokyo, Japan. In Cell Struct Funct, Jan 2016
UNASSIGNED: Bin-Amphiphysin-Rvs161/167 (BAR) domains mold lipid bilayer membranes into tubules, by forming a spiral polymer on the membrane.
Cloning and gene expression of signal transducers and activators of transcription (STAT) homologue provide new insights into the immune response and nucleus graft of the pearl oyster Pinctada fucata.
He et al., Guangzhou, China. In Fish Shellfish Immunol, Dec 2015
The deduced amino acid sequence of PfSTAT contains the conserved STAT_bind domain and the SH2 domain, and the additional Bin/Amphiphysin/Rvs (BAR) domain, but does not have STAT_alpha and STAT_int domains.
Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.
Hwang et al., Seoul, South Korea. In Cell Signal, Nov 2015
Dimerization of arfaptin 2 through the Bin-Amphiphysin-Rvs domain may be essential to inhibit activation of NF-κB through multimodal interactions with IKKβs or IKKβ/NEMO, as ectopic expression of the arfaptin 2 fragment responsible for IKK interactions did not change TNFα-stimulated NF-κB activation.
Different functional modes of BAR domain proteins in formation and plasticity of mammalian postsynapses.
Qualmann et al., Jena, Germany. In J Cell Sci, Oct 2015
Among such membrane shapers, the superfamily of Bin-Amphiphysin-Rvs (BAR) domain proteins has recently taken center stage.
Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.
Grant et al., United States. In Plos Genet, Sep 2015
We demonstrate that downstream basolateral recycling regulators, GTPase RAB-10/Rab10 and BAR domain protein AMPH-1/Amphiphysin, bind to TBC-2 and help to recruit it to endosomes.
Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells.
Gasman et al., Paris, France. In J Neurosci, Sep 2015
Oligophrenin-1 (OPHN1) is a protein with multiple domains including a Rho family GTPase-activating (Rho-GAP) domain, and a Bin-Amphiphysin-Rvs (BAR) domain.
Building endocytic pits without clathrin.
Mayor et al., Paris, France. In Nat Rev Mol Cell Biol, May 2015
Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules.
F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.
Wang et al., Shanghai, China. In J Hematol Oncol, 2014
In the past ten years, a novel protein family, Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain proteins, has been identified to be the most important coordinators in membrane curvature regulation.
Design of small molecules targeting I-BAR proteins.
Gu et al., Nanjing, China. In Curr Pharm Des, 2014
Missing in metastasis (MIM, also MTSS1) is a member of the inverse Bin-Amphiphysin-Rvs (I-BAR) family that senses and stabilizes negative membrane protrusions.
Membrane-associated cargo recycling by tubule-based endosomal sorting.
Cullen et al., Amsterdam, Netherlands. In Semin Cell Dev Biol, 2014
These tubules are formed and stabilized through the scaffolding properties of cytosolic Bin/Amphiphysin/Rvs (BAR) proteins that comprise phosphoinositide-detecting moieties, recruiting these proteins to specific endosomal membrane areas.
BAR domain proteins regulate Rho GTPase signaling.
Aspenström, Stockholm, Sweden. In Small Gtpases, 2013
The common denominator is the Bin-Amphiphysin-Rvs (BAR) domain that not only confers targeting to lipid bilayers, but also provides scaffolding to mold lipid membranes into concave or convex surfaces.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Toward quantitative characterization of the binding profile between the human amphiphysin-1 SH3 domain and its peptide ligands.
Zhang et al., Chongqing, China. In Amino Acids, 2010
structure-based approach to prediction of peptide-binding behavior of SH3 domain of amphiphysin-1: statistical modeling
Applying chemometrics approaches to model and predict the binding affinities between the human amphiphysin SH3 domain and its peptide ligands.
Xu et al., Ji'an, China. In Protein Pept Lett, 2010
investigation of binding affinities of decapeptide ligands with amphiphysin SH3 domain using QSAR models
Dynamic interaction of amphiphysin with N-WASP regulates actin assembly.
Takei et al., Okayama, Japan. In J Biol Chem, 2010
amphiphysin interaction with N-WASP regulates actin assembly
AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.
Grant et al., United States. In Nat Cell Biol, 2009
Here we show that endogenous C. elegans AMPH-1, the only C. elegans member of the Amphiphysin/BIN1 family of BAR (Bin1-Amphiphysin-Rvs161p/167p)-domain-containing proteins, colocalizes with RME-1 on recycling endosomes in vivo, that amph-1-deletion mutants are defective in recycling endosome morphology and function, and that binding of AMPH-1 Asn-Pro-Phe(Asp/Glu) sequences to the RME-1 EH-domain promotes the recycling of transmembrane cargo.
Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells.
Yamada et al., Okayama, Japan. In Acta Med Okayama, 2008
cooperative function of dynamin 2 and amphiphysin 1 in phosphatidylserine-dependent phagocytosis is strongly suggested in sertoli cells
SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.
Cullen et al., Bristol, United Kingdom. In Nat Cell Biol, 2007
Here, we establish that through its phox homology (PX) and Bin-Amphiphysin-Rvs (BAR) domains, sorting nexin-4 (SNX4) is associated with tubular and vesicular elements of a compartment that overlaps with peripheral early endosomes and the juxtanuclear endocytic recycling compartment (ERC).
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions.
Brodin et al., Stockholm, Sweden. In Science, 1997
Amphiphysin contains an SH3 domain and is a major dynamin binding partner at the synapse.
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