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Adenosine monophosphate deaminase 2

AMPD2, AMP Deaminase, AMP deaminase 2
Adenosine monophosphate deaminase-2 (EC catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.[supplied by OMIM, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, FasT
Papers on AMPD2
Safety evaluation of AMP deaminase from Aspergillus oryzae.
Roberts et al., Japan. In Food Chem Toxicol, Dec 2015
AMP deaminase showed no evidence of genotoxicity in the in vitro tests.
Structure-function relationships in mammalian histidine-proline-rich glycoprotein.
Raggi et al., Pisa, Italy. In Biochimie, Nov 2015
This observation provides a structural basis to the function of HPRG as an intracellular zinc chaperone which has been suggested by the involvement of the protein in the maintenance of the quaternary structure of skeletal muscle AMP deaminase (AMPD).
Sodium nitrite-induced oxidative stress causes membrane damage, protein oxidation, lipid peroxidation and alters major metabolic pathways in human erythrocytes.
Mahmood et al., Alīgarh, India. In Toxicol In Vitro, Oct 2015
However, there was a significant increase in acid phosphatase and also AMP deaminase, a marker of erythrocyte oxidative stress.
A continuous spectrophotometric assay for monitoring adenosine 5'-monophosphate production.
First, Shreveport, United States. In Anal Biochem, Sep 2015
Specifically, we have coupled the conversion of AMP to inosine 5'-monophosphate (IMP) (by AMP deaminase) to the oxidation of IMP (by IMP dehydrogenase).
Inhibition of AMP deaminase as therapeutic target in cardiovascular pathology.
Smolenski et al., Gdańsk, Poland. In Pharmacol Rep, Aug 2015
AMP deaminase (AMPD; EC catalyzes hydrolysis of the amino group from the adenine ring of AMP resulting in production of inosine 5'-monophosphate (IMP) and ammonia.
Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways.
Li et al., Daqing, China. In J Biomed Inform, Apr 2015
Furthermore, the performance for mercaptopurine was significant: 6 known targets (ADSL, GMPR2, GMPR, HPRT1, AMPD3, AMPD2) were ranked in the top 15 and other four out of the top 15 (MAT2A, CDKN1A, AREG, JUN) have the potentialities to become new targets for cancer therapy.
AMP-deaminase from thymus of patients with myasthenia gravis.
Kaletha et al., Gdańsk, Poland. In Nucleosides Nucleotides Nucleic Acids, 2014
Interestingly most of MG patients manifest parallely also some abnormalities of the thymus.AMP-deaminase (AMPD) from human thymus was not a subject of studies up to now.
AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
Morisaki et al., Suita, Japan. In Bmc Endocr Disord, 2014
AMPD1, an isoform of AMP deaminase (AMPD), is suggested to play roles in the regulation of glucose metabolism through controlling AMP-activated protein kinase (AMPK) activation.
Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel.
Johnson et al., Aurora, United States. In Plos One, 2014
We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: metabolism through AMP deaminase (AMPD2) (summer) and activation of AMP-activated protein kinase (AMPK) (winter).
AMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatment.
Barton et al., Gdańsk, Poland. In Cardiovasc Drugs Ther, 2014
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
The role of histidine-proline-rich glycoprotein as zinc chaperone for skeletal muscle AMP deaminase.
Raggi et al., Pisa, Italy. In Biomolecules, 2013
We propose that the complex formed in skeletal muscle by the Zn2+ metalloenzyme AMP deaminase (AMPD) and the metal binding protein histidine-proline-rich glycoprotein (HPRG) acts in this manner.
AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.
Gleeson et al., San Diego, United States. In Cell, 2013
We describe a distinct early-onset neurodegenerative condition resulting from mutations in the adenosine monophosphate deaminase 2 gene (AMPD2).
Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs.
Nánási et al., Debrecen, Hungary. In Curr Med Chem, 2010
We discuss the chemical, pharmacological and clinical features of these compounds: (1) inhibitors of membrane adenosine transporters (NBTI, dipyridamole), (2) inhibitors of adenosine deaminase (coformycin, EHNA), (3) inhibitors of adenosine kinase (tubercidin, aristeromycin), (4) inhibitors of AMP deaminase (GP3269), (5) activators of 5'-nucleotidase (methotrexate), (6) adenosine regulators (acadesine) and (7) allosteric adenosine receptor modulators (PD81723, LUF6000).
A novel method for testing association of multiple genetic markers with a multinomial trait.
Guo et al., Houston, United States. In Proc Am Stat Assoc, 2010
Applying the method to study 32 genes in our Mexican-American samples for association with prediabetes through either impaired glucose tolerance (IGT) or impaired fasting glucose (IFG), we found 3 genes (SORCS1, AMPD1, PPAR) associated with both IGT and IFG, while 5 genes (AMPD2, PRKAA2, C5, TCF7L2, ITR) with the IGT mechanism only and 6 genes (CAPN10, IL4,NOS3, CD14, GCG, SORT1) with the IFG mechanism only.
Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC).
Roszkowska et al., Gdańsk, Poland. In Mol Cell Biochem, 2008
This is a first report evidencing the pattern of AMPD genes expression in neoplastic human liver.
Isolation and properties of AMP deaminase from jumbo squid (Dosidicus gigas) mantle muscle from the Gulf of California, Mexico.
Gollas-Galvan et al., Hermosillo, Mexico. In Food Chem, 2008
Isoelectric focusing of this enzyme showed a pI of 5.76, which agrees with pI values of AMP deaminase from other invertebrate organisms.
N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L.
Sabina et al., Milwaukee, United States. In Biochem Biophys Res Commun, 2003
N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L.
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