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Amelogenin, Y-linked

This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Amelogenin, CAN, SRY, POLYMERASE, HAD
Papers on AMELY
Mutational landscape of the human Y chromosome-linked genes and loci in patients with hypogonadism.
Ali et al., New Delhi, India. In J Genet, Dec 2015
FISH uncovered mosaicism for SRY, AMELY,DAZ genes and DYZ1 arrays, structural rearrangement for AMELY (31%) and duplication of DAZ (57%) genes.
Cell-Free RNA Is a Reliable Fetoplacental Marker in Noninvasive Fetal Sex Determination.
Veltman et al., Maastricht, Netherlands. In Clin Chem, Dec 2015
METHODS: We developed a novel multiplex, single-tube, noninvasive fetal sex determination assay by combining amplification of AMELY cffDNA with one-step reverse transcription (RT)-PCR of trophoblast-derived cell-free RNA (cfRNA), which functions as a sex-independent fetoplacental marker.
Towards simultaneous individual and tissue identification: A proof-of-principle study on parallel sequencing of STRs, amelogenin, and mRNAs with the Ion Torrent PGM.
Kayser et al., Rotterdam, Netherlands. In Forensic Sci Int Genet, Jul 2015
We demonstrated that 9 autosomal STRs commonly used for individual identification (CSF1PO, D16S539, D3S1358, D5S818, D7S820, D8S1179, TH01, TPOX, and vWA), the AMELX/AMELY system widely applied for sex identification, and 12 mRNA markers previously established for forensic tissue identification (ALAS2 and SPTB for peripheral blood, MMP10 and MMP11 for menstrual blood, HTN3 and STATH for saliva, PRM1 and TGM4 for semen, CYP2B7P1 and MUC4 for vaginal secretion, CCL27 and LCE1C for skin) together with two candidate reference mRNA markers (HPRT1 and SDHA) can all be successfully combined.
Copy number variation in the human Y chromosome in the UK population.
Xue et al., Sanger, United States. In Hum Genet, Jul 2015
These included a large duplication encompassing the AMELY and TBL1Y genes that probably has no phenotypic effect, partial deletions of the TSPY cluster and AZFc region that may influence spermatogenesis, and other variants with unknown functional implications, including abundant variation in the number of RBMY genes and/or pseudogenes, and a novel complex duplication of two segments overlapping the AZFa region and including the 3' end of the UTY gene.
Y-chromosomal variation of local goat breeds of Turkey close to the domestication centre.
Ertugrul et al., Ankara, Turkey. In J Anim Breed Genet, Apr 2015
In this study, the male-specific region markers, sex-determining region-Y (SRY), amelogenin (AMELY) and zinc finger (ZFY) were analysed in seven Turkish native goat breeds, Angora, Kilis, Hair, Honamlı, Norduz, Gürcü and Abaza.
Amelogenin test abnormalities revealed in Belarusian population during forensic DNA analysis.
Borovko et al., Minsk, Belarus. In Forensic Sci Int Genet, Mar 2015
In current study we report 11 cases of amelogenin abnormalities identified in males of Belarusian origin: 9 cases of AMELY dropout and 2 cases of AMELX dropout.
Determined about sex: sex-testing in 45 primate species using a 2Y/1X sex-typing assay.
Balaresque et al., Toulouse, France. In Forensic Sci Int Genet, 2015
The most widely used method, AMELY/X, and its alternatives suffer from a set of drawbacks in humans and can rarely be used in New World primate species.
Identification of cDNA sequences and alternative splicing patterns of canine AMEL genes (AMELX and AMELY).
Zhao et al., Changchun, China. In Genet Mol Res, 2014
There are two amelogenin genes (AMELX and AMELY) located on the X and Y chromosomes, respectively, in dogs.
Noninvasive Digital Detection of Fetal DNA in Plasma of 4-Week-Pregnant Women following In Vitro Fertilization and Embryo Transfer.
Coskun et al., Riyadh, Saudi Arabia. In Plos One, 2014
The genomic regions of both X and Y chromosome-specific sequences (AMELX and AMELY) were concurrently amplified in two sequential PCRs; first by conventional PCR then by BEAMing.
Deletion mapping of the regions with AMELY from two Chinese males.
Zhou et al., Shanghai, China. In Leg Med (tokyo), 2014
However, the null of amelogenin Y (AMELY) can result in the incorrect genotyping of male samples as females.
Novel Y-chromosome polymorphisms in Chinese domestic yak.
Lei et al., China. In Anim Genet, 2014
In this study, we screened a total of 16 Y-chromosome-specific gene segments from the ZFY, SRY, UTY, USP9Y, AMELY and OFD1Y genes to identify Y-SNPs in domestic yaks.
Detection of the deletion on Yp11.2 in a Chinese population.
Sun et al., Guangzhou, China. In Forensic Sci Int Genet, 2014
Mutations that cause dropout of Y chromosomal Amelogenin gene (AMELY) could lead to errors in gender determination and mixture interpretation.
Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.
Pyatt et al., Columbus, United States. In Forensic Sci Int Genet, 2013
In this study, we analyzed results from 32,850 samples sent for clinical array comparative genomic hybridization (CGH) analysis for the presence of CNV at regions containing the 13 CODIS (Combined DNA Index System) STR, and the Amelogenin X (AMELX) and Amelogenin Y (AMELY) loci.
Deletion of amelogenin Y-locus in forensics: literature revision and description of a novel method for sex confirmation.
Caenazzo et al., Padova, Italy. In J Forensic Leg Med, 2013
Today, the molecular technique routinely for sex determination in forensics is based the detection of length variations in the X-Y homologous amelogenin gene (AMELX and AMELY).
Molecular characterization of a polymorphic 3-Mb deletion at chromosome Yp11.2 containing the AMELY locus in Singapore and Malaysia populations.
Yap et al., Singapore, Singapore. In Hum Genet, 2007
The combined frequency of the AMELY null allele in Singapore and Malaysia populations is 2.7%, 0.6% in Indian and Malay ethnic groups respectively. It is absent among 541 Chinese screened.
Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y.
Parkin et al., Leicester, United Kingdom. In Hum Mol Genet, 2007
Multigene deletions encompassing AMELY on short arm of chromosome Y.
47,XXX male: A clinical and molecular study.
Fukutani et al., Tokyo, Japan. In Am J Med Genet, 2001
PCR analysis showed the presence of Yp portion with the breakpoint between DYS264 and AMELY.
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