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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Autophagy/beclin 1 regulator 1

Ambra1, activating molecule in Beclin1-regulated autophagy
Top mentioned proteins: Beclin 1, LC3, CAN, Vps34, bcl-2
Papers on Ambra1
Growth attenuation is associated with histone deacetylase 10-induced autophagy in the liver.
Gat-Yablonski et al., Tel Aviv-Yafo, Israel. In J Nutr Biochem, Jan 2016
Food restriction led to significant reduction in liver weight, concomitant with increased autophagy (i.e., a decrease in the level of P62 and an increase in the expression level of Ambra1 and Atg16L2 genes in the RES group).
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules.
Falasca et al., Cagliari, Italy. In Oncotarget, Jan 2016
The ultrastructural and immunohistochemical analyses of KRT-19-positive preneoplastic hepatocytes showed the presence of autophagic vacuoles which was associated with p62, Ambra1 and Beclin1 protein accumulation suggesting that a differential modulation of autophagy occurs at early stages of the oncogenesis in KRT-19-positive vs negative lesions.
shRNA-mediated AMBRA1 knockdown reduces the cisplatin-induced autophagy and sensitizes ovarian cancer cells to cisplatin.
Tian et al., China. In J Toxicol Sci, Dec 2015
Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells and cancer cells.
Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria.
Valle et al., Padova, Italy. In Mol Phylogenet Evol, Dec 2015
UNASSIGNED: Ambra1 is a positive regulator of autophagy, a lysosome-mediated degradative process involved both in physiological and pathological conditions.
Nerve growth factor and autophagy: effect of nasal anti-NGF-antibodies administration on Ambra1 and Beclin-1 expression in rat brain.
Aloe et al., Roma, Italy. In Growth Factors, Oct 2015
Treatment also affects - in a brain region-dependent manner - the expression of the autophagic proteins Beclin-1 and Ambra1, as well as that of proteins belonging to the Bcl2 family, namely Bax and Bcl-2, reflecting apoptotic dysregulation.
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.
Green et al., Memphis, United States. In Nat Cell Biol, Jul 2015
Rubicon is recruited to LAPosomes and is required for the activity of a Class III PI(3)K complex containing UVRAG but lacking ATG14 and Ambra1.
Ambra1 at a glance.
Cecconi et al., Roma, Italy. In J Cell Sci, Jul 2015
The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved adapter protein that is part of the autophagy signaling network.
Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: a vital component of autophagy.
Changotra et al., Solan, India. In Gene, Jun 2015
It receives signals from upstream modulators such as TIP60, mTOR and AMPK and relays them to its downstream substrates like Ambra1 and ZIP kinase.
Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression.
Cecconi et al., Roma, Italy. In Plos One, 2014
In this study, we investigated the cellular mechanisms regulating the autophagy gene Ambra1, after exposure to a hypoxia mimetic, cobalt chloride (CoCl2).
Enhanced Autophagy of Adipose-Derived Stem Cells Grown on Chitosan Substrates.
Hsu et al., Taipei, Taiwan. In Biores Open Access, 2014
The upstream components of autophagy signal pathway-UNC51-like kinase 1 (Ulk1), autophagy-related protein 13 (Atg13), and autophagy/beclin-1 regulator 1 (Ambra1) genes were more highly expressed in ADSC spheroids before and after adding H2O2 than those in the conventional culture.
Beclin-1 and its role as a target for anticancer therapy.
Rybczynska et al., PoznaƄ, Poland. In J Physiol Pharmacol, 2014
Beclin-1 is a protein that plays a central role in autophagy; it interacts with multiple cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, IP3R, PINK and survivin) to promote the formation of the Beclin-1-Vps34-Vps15 complex which triggers the autophagy protein cascade.
Ambra1 at the crossroad between autophagy and cell death.
Piacentini et al., Roma, Italy. In Oncogene, 2013
This review is focused on the role that Ambra1, a central component of the autophagosome formation machinery, has in the switch between autophagy and apoptosis and its implication in cancer development and chemotherapy resistance.
Beclin-1: autophagic regulator and therapeutic target in cancer.
Liu et al., Chengdu, China. In Int J Biochem Cell Biol, 2013
Recent data indicate that Beclin-1 may interact with some co-factors such as Class III phosphatidylinositol 3-kinase (PI3KCIII)/Vps34, Vps15, ATG14L/Barkor, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, Survivin, Akt and Bcl-2/Bcl-XL to positively or negatively orchestrate the Beclin-1 interactome, thereby co-regulating the autophagy process.
Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.
de Pablo et al., Madrid, Spain. In Autophagy, 2012
These results reveal new roles for autophagy-related molecules Atg5 and Ambra1 during early neuronal differentiation of stem/progenitor cells.
Parkin interacts with Ambra1 to induce mitophagy.
Vandenberghe et al., Leuven, Belgium. In J Neurosci, 2011
These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy.
The Beclin 1 network regulates autophagy and apoptosis.
Tang et al., Pittsburgh, United States. In Cell Death Differ, 2011
It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes, thereby inducing autophagy.
Ambra1 regulates autophagy and development of the nervous system.
Cecconi et al., Roma, Italy. In Nature, 2007
Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death
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