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Crystallin, alpha B

alphaB-crystallin, CRYAB
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HSP27, HAD, fibrillin-1, AGE
Papers on alphaB-crystallin
High level of αB-crystallin contributes to the progression of osteosarcoma.
Cheng et al., Nanchang, China. In Oncotarget, Feb 2016
UNASSIGNED: Accumulating evidences indicate the elevated expression of αB-crystallin (Cryab) is implicated in tumorigenesis.
Fixed single-cell transcriptomic characterization of human radial glial diversity.
Ramanathan et al., Seattle, United States. In Nat Methods, Jan 2016
Using FRISCR, we profiled primary human RG that constitute only 1% of the midgestation cortex and classified them as ventricular zone-enriched RG (vRG) that express ANXA1 and CRYAB, and outer subventricular zone-localized RG (oRG) that express HOPX.
The interactive association between heat shock factor 1 and heat shock proteins in primary myocardial cells subjected to heat stress.
Bao et al., Nanjing, China. In Int J Mol Med, Jan 2016
However, no significant changes were observed in the crystallin, alpha B (CRYAB, also known as HSP beta-5) expression levels during the 480‑min period of exposure to heat stress.
Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.
Wanner et al., Los Angeles, United States. In Glia, Jan 2016
In contrast, α crystallin (CRYAB) was present in acutely injured astrocytes, and absent from uninjured and reactive astrocytes, demonstrating novel marker differences among postinjury astrocytes.
Mitochondrial abnormalities in the myofibrillar myopathies.
Reichmann et al., Dresden, Germany. In Eur J Neurol, Nov 2015
Causative mutations have been identified in the genes MYOT, LDB3, DES, CRYAB, FLNC, BAG3, DNAJB6, FHL1, PLEC and TTN, which encode proteins which either reside in the Z-disc or associate with the Z-disc.
Myofibrillar myopathies: State of the art, present and future challenges.
Eymard et al., Paris, France. In Rev Neurol (paris), Oct 2015
The boundaries of this concept are still uncertain, and whereas six genes (DES, CRYAB, LDB3/ZASP, MYOT, FLNC and BAG3) are now classically considered as responsible for MFM, other entities such as FHL1 myopathy or Hereditary Myopathy with Early Respiratory Failure linked to mutations of titin can now as well be included in this group.
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
Alkuraya et al., Riyadh, Saudi Arabia. In Trans Am Ophthalmol Soc, Sep 2015
Ten families had a founder CRYBB1 deletion (all with bilateral central pulverulent cataract), two had the same missense mutation in CRYAB (both with bilateral juvenile cataract with marked variable expressivity), and two had different mutations in FYCO1 (both with bilateral posterior capsular abnormality).
[Expression and mechanism of alphaB-crystallin in retina and extraocular tissues and organs].
Xia et al., In Fa Yi Xue Za Zhi, 2014
alphaB-crystallin is the structural protein of vertebrate lens, which is widely expressed in non-lens tissue.
Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter.
Amor et al., Amsterdam, Netherlands. In Acta Neuropathol Commun, 2014
With the exception of alpha B-crystallin (HSPB5), little is known about the roles of small HSPs in disease.
Janus faces of amyloid proteins in neuroinflammation.
Kurnellas et al., Stanford, United States. In J Clin Immunol, 2014
In 2001 we noted that aB crystallin (cryab) was the most abundant transcript found in MS lesions, but not in healthy brains.
Role of α-crystallin B in regulation of stress induced cardiomyocyte apoptosis.
Sarkar et al., Calcutta, India. In Cardiovasc Hematol Agents Med Chem, 2013
α-Crystallin B (CRYAB) is an abundant small HSP that confers protection to cardiomyocytes against various stress stimuli.
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.
Zhou et al., Shanghai, China. In Nature, 2013
Here we show that the astrocytic dopamine D2 receptor (DRD2) modulates innate immunity through αB-crystallin (CRYAB), which is known to suppress neuroinflammation.
CRYAB-650 C>G (rs2234702) affects susceptibility to Type 1 diabetes and IAA-positivity in Swedish population.
Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups et al., Stockholm, Sweden. In Hum Immunol, 2012
genetic polymorphism is associated with Type 1 diabetes in the Swedish population
Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.
Steinman et al., Stanford, United States. In J Biol Chem, 2012
Therapeutic effects of systemic administration of chaperone alphaB-crystallin associated with binding proinflammatory plasma proteins.
αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development.
Li et al., Changsha, China. In Curr Mol Med, 2012
alphaA and alphaB regulate caspase-3 and Bax in vitro and in vivo to regulate lens differentiation.
Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics.
Biswas et al., Cleveland, United States. In Plos One, 2011
Data show that among the three small heat shock proteins, Hsp27, alphaA- and alphaB-crystallin, the R12A mutation improved the chaperone function of only alphaA-crystallin.
Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone.
King et al., Cambridge, United States. In Plos One, 2011
The perturbed conformation of human gamma-crystallin D, I90F mutant, was recognized and bound by both alpha-crystallin A and alpha-crystallin B chaperones.
Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.
Benjamin et al., Salt Lake City, United States. In Cell, 2007
Transgenic mice overexpressing cardiac-specific human mutant CryAB (hR120GCryAB) recapitulate lethal human cardiomyopathy with reductive stress and dysregulation of glucose-6-phosphate dehydrogenase.
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Steinman et al., Stanford, United States. In Nature, 2007
CRYAB is a potent negative regulator acting as a brake on several inflammatory pathways in both the immune system and central nervous system (CNS).
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Bush et al., United States. In Lancet, 2003
Synthetic Abeta bound alphaB-crystallin, an abundant cytosolic lens protein.
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