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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Alpha-methylacyl-CoA racemase

alpha-methylacyl-CoA racemase, Methylacyl-CoA Racemase, 2-Arylpropionyl-CoA epimerase, 2-methylacyl CoA racemase, mARC1, Da18
enzmyme that converts pristanoyl-CoA and C27-bile acyl-CoAs to (S)-stereoisomers; involved in the degradation of the side chain of bile acid intermediates [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: alpha-methylacyl-CoA racemase, ACID, CAN, cytokeratin, HAD
Papers on alpha-methylacyl-CoA racemase
Atypical Renal Cysts: A Morphologic, Immunohistochemical, and Molecular Study.
Epstein et al., Indianapolis, United States. In Am J Surg Pathol, Feb 2016
We retrieved 29 cases (15 nephrectomies, 14 partial nephrectomies) from the surgical pathology files of Johns Hopkins Hospital from 1993 to 2014 and performed immunohistochemistry for CK7, alpha-methylacyl-CoA racemase (AMACR), CAIX, and CD10 and fluorescence in situ hybridization for trisomy 7 and 17 and 3p deletion.
Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.
Schiffmann et al., Frankfurt am Main, Germany. In Eur J Immunol, Jan 2016
Alpha-methylacyl-CoA racemase (AMACR) converts R-configuration branched fatty acids into the S-configuration, thereby preparing them for β-oxidation.
Clinical significance of single microscopic focus of adenocarcinoma at prostate biopsy.
Karaman et al., İstanbul, Turkey. In Prostate Int, Dec 2015
In pathological examination; high molecular weight cytokeratin (HMW-CK), p63, and alpha-methylacyl-CoA racemase (AMACR) were used for differential diagnosis.
The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.
Neal et al., Cambridge, United Kingdom. In Eur Urol, Dec 2015
AR regulation of α-methylacyl-CoA racemase expression and three other genes (FAM129A, RAB27A, and KIAA0101) was confirmed.
Horseradish peroxidase and aptamer dual-functionalized nanoprobe for the amplification detection of alpha-methylacyl-CoA racemase.
Liu et al., Fuzhou, China. In Anal Chim Acta, Nov 2015
Alpha-methylacyl-CoA racemase (AMACR) is over-expressed in many cancer types and can serve as a novel diagnostic biomarker.
Expression of p53 predicts risk of prevalent and incident advanced neoplasia in patients with Barrett's esophagus and epithelial changes indefinite for dysplasia.
Liu et al., Cleveland, United States. In Gastroenterol Rep (oxf), Nov 2015
Immunohistochemical analyses were used to semi-quantify the expression of p53, α-methylacyl-CoA racemase (AMACR), and cyclin D1.
[Related biomarkers in the diagnosis of prostate cancer].
Liu et al., In Zhonghua Nan Ke Xue, Oct 2015
This review focuses on some of the more promising tumor biomarkers such as prostate cancer antigen 3, early prostate cancer antigen, prostate-specific membrane antigen, alpha-methylacyl-CoA racemase, and vascular endothelial growth factor.
Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.
Ingelman-Sundberg et al., Stockholm, Sweden. In Plos One, 2014
Recently two novel enzymes were identified in the outer mitochondrial membrane, mARC1 and mARC2.
The expression and clinical effects of alpha-methylacyl-CoA racemase (AMACR/ P504S) as an immunohistochemical marker in malign pleural mesothelioma.
Karakaya et al., In Turk J Med Sci, 2014
BACKGROUND/AIM: Alpha-methylacyl-CoA racemase (AMACR), an intracellular enzyme involved in lipid metabolism, has emerged as an immunohistochemical marker for many types of cancer.
Seminal vesicle intraepithelial neoplasia versus basal cell hyperplasia in a seminal vesicle.
Scarpelli et al., Ancona, Italy. In Eur Urol, 2014
Prostate-specific antigen, prostate-specific acid phosphatase, prostate-specific membrane antigen, prostein (P501S), alpha-methylacyl-CoA racemase, and GATA binding protein 3 (GATA3) were negative; p63, 34betaE12, cytokeratin 5/6, and p53 were positive in cells in basal and suprabasal positions, whereas CA-125 was expressed in the luminal cells.
Lipid metabolism in prostate cancer.
Monaco et al., New York City, United States. In Am J Clin Exp Urol, 2013
A central role for fatty acid oxidation in supplying energy to the prostate cancer cell is supported by the observation that the peroxisomal enzyme, α-methylacyl-CoA racemase (AMACR), which facilitates the transformation of branched chain fatty acids to a form suitable for β-oxidation, is highly overexpressed in prostate cancer compared with normal prostate.
Recent advances of immunohistochemistry for diagnosis of renal tumors.
Nagashima et al., Kōchi, Japan. In Pathol Int, 2013
In dialysis-related RCC, neoplastic cells of acquired cystic disease-associated RCC are positive for alpha-methylacyl-CoA racemase (AMACR), but negative for cytokeratin (CK) 7, whereas clear cell papillary RCC shows the inverse pattern.
Beyond prostate-specific antigen - future biomarkers for the early detection and management of prostate cancer.
Eeles et al., United Kingdom. In Clin Oncol (r Coll Radiol), 2012
Here we review the use and limitations of prostate-specific antigen and its subtypes, urinary biomarkers including PCA3, alpha-methylacyl-CoA racemase, the TMPRSS2-ERG fusion gene and microseminoprotein-beta, and other novel markers in both serum and urine.
Identification of a cell of origin for human prostate cancer.
Witte et al., Los Angeles, United States. In Science, 2010
The cooperative effects of AKT, ERG, and androgen receptor in basal cells recapitulated the histological and molecular features of human prostate cancer, with loss of basal cells and expansion of luminal cells expressing prostate-specific antigen and alpha-methylacyl-CoA racemase.
The role of alpha-methylacyl-CoA racemase in bile acid synthesis.
Novikov et al., Springfield, United States. In Biochem J, 2002
role of alpha-methylacyl-CoA racemase in bile acid synthesis
Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy.
Wanders et al., Amsterdam, Netherlands. In Nat Genet, 2000
In all three patients we discovered a deficiency of alpha-methylacyl-CoA racemase (AMACR).
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