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Fucosidase, alpha-L- 1, tissue

The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, HAD, N-acetyl-beta-D-glucosaminidase, lacZ, Neuraminidase
Papers on alpha-L-Fucosidase
Drosophila sperm surface alpha-L-fucosidase interacts with the egg coats through its core fucose residues.
Pasini et al., Milano, Italy. In Insect Biochem Mol Biol, Aug 2015
Sperm-oocyte interaction during fertilization is multiphasic, with multicomponent events, taking place between egg's glycoproteins and sperm surface receptors.
Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma.
Li et al., Fuding, China. In Febs Open Bio, 2014
The purpose of this study was to evaluate the diagnostic efficiency for hepatocellular carcinoma (HCC) with the combined analysis of alpha-l-fucosidase (AFU), alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1).
Alpha-L-fucosidase isoenzyme iso2 from Paenibacillus thiaminolyticus.
Králová et al., Praha, Czech Republic. In Bmc Biotechnol, 2014
BACKGROUND: α-L-Fucosidases are enzymes involved in metabolism of α-L-fucosylated molecules, compounds with a fundamental role in different life essential processes including immune response, fertilization and development, but also in some serious pathological events.
Serum gp73 is also a biomarker for diagnosing cirrhosis in population with chronic HBV infection.
Wei et al., Beijing, China. In Clin Biochem, 2014
Serum biomarkers, including gp73, alpha-fetoprotein (AFP), alpha-l-fucosidase, and Lens culinaris agglutinin-reactive fraction of AFP, were determined.
Evaluation of squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IGM) and alpha-L-fucosidase (AFU) as novel diagnostic biomarkers for hepatocellular carcinoma.
Shousha et al., Cairo, Egypt. In Tumour Biol, 2014
Serum alpha-L-fucosidase (AFU) and squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IgM) were found to be useful markers in diagnosing HCC.
Carcinogenic effects of aflatoxin B1 among wheat handlers.
Elhamshary et al., In Int J Occup Environ Health, 2014
METHODS: Serum AFB1/albumin (AFB1/Alb), alpha-fetoprotein (AFP), alpha-l-fucosidase (AFU), and arginase were estimated in exposed wheat handlers including millers and bakers.
Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2.
Irwin et al., Dublin, Ireland. In Mol Cell Biochem, 2014
The regulation of FUCA1 and FUCA2 gene expression and enzyme activity in response to asthma-associated Th2 cytokines and, for contrast, Th1 cytokine IFN-γ, were investigated in a human airway cell line.
Diagnostic value of alpha-L-fucosidase for hepatocellular carcinoma: a meta-analysis.
Song et al., China. In Tumour Biol, 2014
Alpha-L-fucosidase (AFU) has been proposed as a tumor marker for diagnosis of HCC in many studies.
Alpha-1-fucosidase as a prognostic indicator for hepatocellular carcinoma following hepatectomy: a large-scale, long-term study.
Cheng et al., Shanghai, China. In Br J Cancer, 2014
BACKGROUND: Preoperative alpha-L-fucosidase (AFU) has been used as a diagnostic biomarker for hepatocellular carcinoma (HCC), but its role as a prognostic predictor after partial hepatectomy has not been well defined.
Syntheses and biological activities of 1,4-iminoalditol derivatives as alpha-L-fucosidase inhibitors.
Robina et al., Sevilla, Spain. In Chimia (aarau), 2010
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of alpha-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
Present and future possibilities for early diagnosis of hepatocellular carcinoma.
Wiercinska-Drapalo et al., Warsaw, Poland. In World J Gastroenterol, 2010
In this review, we will focus on other biomarkers that seem to improve HCC diagnosis, such as AFP-L3, des-gamma-carboxyprothrombin, alpha-l-fucosidase, gamma-glutamyl transferase, glypican-3, squamous cell carcinoma antigen, a new generation of immunoglobulin M-immunocomplexes, and very promising gene-expression profiling.
Spectrofluorimetric method for measuring the activity of the enzyme alpha-L-fucosidase using the ion associate of 2-chloro-4-nitro phenol-rhodamine-B.
Elsofy et al., Jiddah, Saudi Arabia. In Talanta, 2009
Data show that the correlation between the fluorescence activity of the enzyme AFU by the developed procedures and the standard method was positive and highly significant in patients and controls.
The alpha-L-fucosidase from Sulfolobus solfataricus.
Moracci et al., Napoli, Italy. In Extremophiles, 2008
In Archaea the first alpha-L-fucosidase was identified in Sulfolobus solfataricus as interrupted gene expressed by programmed -1 frameshifting.
Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm.
Bean et al., Bethlehem, United States. In Mol Reprod Dev, 2007
The fucosidase has a role in the intimate species signature interactions between sperm and oocyte.
Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.
Zwierz et al., Białystok, Poland. In Adv Med Sci, 2006
following HIV infection, there is an increased rate of catabolism of glycoconjugates in saliva resulting from changes in the proportions of the activity of isoenzymes A and B of N-acetyl-beta-hexosaminidase, beta-galactosidase and alpha-fucosidase
Purification and characterization of alpha-L-fucosidase from human primary hepatocarcinoma tissue.
Lin et al., Wuhan, China. In World J Gastroenterol, 2006
The purified alpha-L-fucosidase from primary hepatocarcinoma (PHC) is different in its properties from alpha-L-fucosidase in human other organs. The polyclonal antibody prepared in this experiment can be applied to the diagnosis of PHC.
Serum tumor markers for detection of hepatocellular carcinoma.
Luo et al., Chengdu, China. In World J Gastroenterol, 2006
Furthermore, some other tumor markers, such as glypican-3, gamma-glutamyl transferase II, alpha-l-fucosidase, transforming growth factor-beta1, tumor-specific growth factor, have been indicated to be available supplementaries to AFP in the detection.
Enzyme replacement in nervous tissue after allogeneic bone-marrow transplantation for fucosidosis in dogs.
Healy et al., In Lancet, 1986
Bone-marrow transplantation after total lymphoid irradiation in an alpha-L-fucosidase-deficient dog raised the enzyme activity in both visceral and neural tissues with consequent reduction in the severity of storage lesions.
Deficiency of alpha-L-fucosidase.
Zeman et al., In Science, 1972
A new form of alpha-L-fucosidase deficiency has been found in a 20-year-old severely retarded male.
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