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Adrenergic, alpha-1A-, receptor

alpha 1A-adrenoceptor
binds adrenergic compounds and analogs; activates phospholipase C mediated signal transduction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, V1a, Arginine Vasopressin, CAN, Alpha-1
Papers on alpha 1A-adrenoceptor
Administration of the selective alpha 1A-adrenoceptor antagonist silodosin facilitates expulsion of size 5-10 mm distal ureteral stones, as compared to control.
Kohri et al., Nagoya, Japan. In Int Urol Nephrol, 2013
OBJECTIVE: Recently, we reported that alpha 1A-adrenoceptor (AR) is the main participant in phenylephrine-induced human ureteral contraction.
Correlation Between Bladder Mucosal Alpha-1D/Alpha-1A Adrenoceptor mRNA Ratio and Lower Urinary Tract Function in Benign Prostatic Obstruction Patients.
Nishizawa et al., Matsumoto, Japan. In Low Urin Tract Symptoms, 2013
Our objective was to investigate the correlation between the ratio of bladder mucosal alpha-1D/alpha-1A adrenoceptor mRNA and lower urinary tract function in BPO patients.
Activation of alpha1-adrenoceptors enhances glutamate release onto ventral tegmental area dopamine cells.
Jiménez-Rivera et al., San Juan, United States. In Neuroscience, 2012
Presynaptic alpha1-adrenoreceptors (alpha1-AR) activation modulates glutamatergic inputs that affect ventral tegmental area-dopamine neuronal excitability.
Cardiomyocyte overexpression of the α1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning.
Vatner et al., Newark, United States. In Am J Physiol Heart Circ Physiol, 2012
Transcriptionally, however, second window preconditioning is considerably more complex than alpha(1A)-TG preconditioning
Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of α- and β-adrenergic signalling.
Kazdova et al., Praha, Czech Republic. In Exp Biol Med (maywood), 2012
alpha- and beta-adrenergic signalling has a role in epinephrine-dependent control of glucose metabolism in white adipose tissue
Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.
Jin et al., Rochester, United States. In Circ Res, 2012
The alpha(1)-adrenergic stimulation releases Rem1 inhibition of voltage-gated L-type calcium channels through direct phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in an increase of the channel activity and transverse-tubule expression.
Effects of the noradrenergic neurotoxin DSP-4 on the expression of α1-adrenoceptor subtypes after antidepressant treatment.
Nalepa et al., Kraków, Poland. In Pharmacol Rep, 2010
The noradrenergic component of the action of antidepressant agents plays an essential role in the modulation of alpha1A-adrenoceptor subtype in the rat cerebral cortex.
Selective alpha 1A-adrenoceptor stimulation induces Mueller's smooth muscle contraction in an isolated canine upper eyelid preparation.
Yamada et al., Nagano, Japan. In Curr Eye Res, 2010
PURPOSE: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller's muscle) and opening of the eye.
Adjunctive tamsulosin improves stone free rate after ureteroscopic lithotripsy of large renal and ureteric calculi: a prospective randomized study.
Razdan et al., Miami, United States. In Urology, 2010
The presence of alpha-1A adrenoceptor in the distal ureteral smooth muscle prompted the use of tamsulosin, a selective alpha-1 blocker, to promote spontaneous passage of distal ureteral and juxtavesical calculi.
Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study.
Hoel et al., Philadelphia, United States. In Clin Pharmacol Ther, 2010
In order to determine the effects of therapeutic and supratherapeutic doses of silodosin on QT interval, healthy men (N = 186; aged 18-45 years) were randomized to receive silodosin (8 or 24 mg) or placebo for 5 days or moxifloxacin 400 mg (positive control, known to prolong QT) once on day 5.
Urodynamic effects of silodosin, a new alpha 1A-adrenoceptor selective antagonist, for the treatment of benign prostatic hyperplasia.
Yoshida et al., Tochigi, Japan. In Neurourol Urodyn, 2010
AIMS: To investigate urodynamically the effects of silodosin, a new alpha(1A)-adrenoceptor-selective antagonist, in the treatment of benign prostatic hyperplasia (BPH).
Alpha 1-adrenoceptor pharmacome: alpha 1L-adrenoceptor and alpha 1A-adrenoceptor in the lower urinary tract.
Muramatsu et al., Fukui, Japan. In Int J Urol, 2010
A recent study demonstrated that the alpha(1L)-adrenoceptor is a specific phenotype present in the many intact tissues including human LUT, and that it originates from the ADRA1A gene.
The alpha 1B/D-adrenoceptor knockout mouse permits isolation of the vascular alpha 1A-adrenoceptor and elucidates its relationship to the other subtypes.
McGrath et al., Glasgow, United Kingdom. In Br J Pharmacol, 2009
BACKGROUND AND PURPOSE: Mesenteric and carotid arteries from the alpha(1B/D)-adrenoceptor knockout (alpha(1B/D)-KO) were employed to isolate alpha(1A)-adrenoceptor pharmacology and location and to reveal these features in the wild-type (WT) mouse.
Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception.
Wang et al., Chengdu, China. In Med Hypotheses, 2009
Worldwide almost one quarter of all couples practicing contraception rely on male methods.
Short- and long-term effects of silodosin, a selective alpha 1A-adrenoceptor antagonist, on ejaculatory function in rats.
Yoshida et al., Kumamoto, Japan. In Bju Int, 2009
OBJECTIVE: To investigate the short- and long-term effects of silodosin, a selective alpha(1A)-adrenoceptor antagonist, on spontaneous seminal emission by isolated rats and on the properties of alpha(1)-adrenoceptor subtypes in the rat seminal vesicle, as silodosin produces a relatively high incidence rate of abnormal ejaculation and chronic administration of receptor antagonists causes an up-regulation in the targeted receptor.
Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout.
Simpson et al., Fukui, Japan. In Br J Pharmacol, 2008
BACKGROUND AND PURPOSE: The alpha(1L)-adrenoceptor has pharmacological properties that distinguish it from three classical alpha(1)-adrenoceptors (alpha(1A), alpha(1B) and alpha(1D)).
Silodosin, a novel selective alpha 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia.
Kawabe et al., Kumamoto, Japan. In Expert Opin Investig Drugs, 2007
Silodosin is a novel selective alpha(1A)-adrenoceptor (AR) antagonist generated by Kissei Pharmaceutical Co. Ltd.
Medical therapy and quality of life.
Chapple, Sheffield, United Kingdom. In Eur Urol, 1997
These documented properties of the alpha 1A-adrenoceptor antagonists make them an ideal choice for the medical treatment of symptomatic BPH.
[Treatment of benign prostatic hyperplasia with alpha 1-adrenoreceptor antagonists].
Müller et al., Bonn, Germany. In Urologe A, 1997
The development of so-called uroselective alpha 1A-adrenoceptor antagonists in the treatment of BPH possibly leads to further reduction of side effects related to vasodilatation.
The use of alpha-adrenoceptor antagonists in the pharmacological management of benign prostatic hypertrophy: an overview.
Ruffolo et al., King of Prussia, United States. In Pharmacol Res, 1996
Following the cloning of multiple alpha 1-adrenoceptors, the contractile response in human prostate has been assigned to the alpha 1A adrenoceptor.
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