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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog

ALG8, Alg8p
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, ALG6, CAN, POLYMERASE, CDG-Ia
Papers on ALG8
Effect of silver nanoparticles on Pseudomonas putida biofilms at different stages of maturity.
Khan et al., Bangkok, Thailand. In J Hazard Mater, Jul 2015
Extracellular polymeric substance (EPS) levels, measured using crystal violet and total carbohydrate assays, and expression of the EPS-associated genes, csgA and alg8, supported the conclusion that biofilms at later stages were older than those at earlier stages.
ALG8-CDG: novel patients and review of the literature.
Karall et al., Innsbruck, Austria. In Orphanet J Rare Dis, 2014
ALG8-CDG (= CDG-Ih) is one of the less frequently reported types of CDG, maybe due to its severe multi-organ involvement with coagulation disturbances, edema, massive gastrointestinal protein loosing enteropathy, cataracts, and often early death.
Congenital disorders of glycosylation with emphasis on cerebellar involvement.
Jaeken et al., Catania, Italy. In Semin Neurol, 2014
It has also been reported in some patients with ALG1-CDG, ALG3-CDG, ALG9-CDG, ALG6-CDG, ALG8-CDG, PIGA-CDG, DPM1-CDG, DPM2-CDG, B4GALT1-CDG, SLC35A2-CDG, COG1-CDG, COG5-CDG, COG7-CDG, and COG8-CDG.
Analysis of the small RNA spf in the plant pathogen Pseudomonas syringae pv. tomato strain DC3000.
Filiatrault et al., Ithaca, United States. In Microbiology, 2014
Furthermore, expression of alg8 is shown to be influenced by spf, suggesting that this ncRNA plays a role in alginate biosynthesis.
Wrinkled skin and fat pads in patients with ALG8-CDG: revisiting skin manifestations in congenital disorders of glycosylation.
Morava et al., In Pediatr Dermatol, 2014
ALG8-CDG is a severe disorder characterized by dysmorphic features, failure to thrive, protein-losing enteropathy, neurologic and ophthalmologic problems, and developmental delay.
Evaluation of gene expression and alginate production in response to oxygen transfer in continuous culture of Azotobacter vinelandii.
Acevedo et al., Valparaíso, Chile. In Plos One, 2013
The highest molecular weight was not explained by changes in the expression of alg8 and alg44 (genes involved in alginate polymerization).
Expression of alginases and alginate polymerase genes in response to oxygen, and their relationship with the alginate molecular weight in Azotobacter vinelandii.
Galindo et al., Ecatepec, Mexico. In Enzyme Microb Technol, 2013
In cultures at low DOT (1%), in which a high molecular weight alginate (1200 kDa) was synthesized, the transcription levels of alg8 and alg44 (genes encoding alginate polymerase complex), and algX (encoding a protein involved in polymer transport through periplasmic space) were considerably higher as compared to cultures conducted at 5% DOT, under which an alginate with a low MW (42 kDa) was produced.
Alginate production and alg8 gene expression by Azotobacter vinelandii in continuous cultures.
Altamirano et al., Valparaíso, Chile. In J Ind Microbiol Biotechnol, 2012
The objective of this study was to evaluate the effects of agitation rate and inlet sucrose concentrations (ISC) on alginate production and the expression of the genes encoding for alginate-lyases (algL) and the catalytic subunit of the alginate polymerase complex (alg8) in chemostat cultures of Azotobacter vinelandii ATCC 9046.
Severe ALG8-CDG (CDG-Ih) associated with homozygosity for two novel missense mutations detected by exome sequencing of candidate genes.
Prescott et al., Oslo, Norway. In Eur J Med Genet, 2012
Severe ALG8 congenital disorder of glycosylation(CDG-Ih) is associated with homozygosity for two novel missense mutations in exon 8 of ALG8
miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines.
Zhang et al., New Orleans, United States. In Plos One, 2011
Among the cognate genes, six including ALG8, DGKE, GNA12, KLF11, LRPAP1, and MMAB are related to multiple genetic diseases such as depressive disorder and Type-II diabetes.
Two Argentinean Siblings with CDG-Ix: A Novel Type of Congenital Disorder of Glycosylation?
Asteggiano et al., Córdoba, Argentina. In Jimd Rep, 2010
In this context, ALG8-CDG, DPAGT1-CDG, and SRD5A3-CDG were analyzed and no defects were identified.
Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides.
Hennet et al., Zürich, Switzerland. In Hum Mutat, 2009
This review sets the state of the art by listing all mutations identified in the 15 genes (PMM2, MPI, DPAGT1, ALG1, ALG2, ALG3, ALG9, ALG12, ALG6, ALG8, DOLK, DPM1, DPM3, MPDU1, and RFT1) that yield a deficiency of dolichol-linked oligosaccharide biosynthesis.
A new case of ALG8 deficiency (CDG Ih).
Zeman et al., Praha, Czech Republic. In J Inherit Metab Dis, 2009
One of them, ALG8 deficiency (CDG Ih), leads to protein N-glycosylation defects caused by malfunction of glucosyltransferase 2 (Dol-P-Glc:Glc1-Man(9)-GlcNAc(2)-P-P-Dol glucosyltransferase) resulting in inefficient addition of the second glucose residue onto lipid-linked oligosaccharides.
Novel ALG8 mutations expand the clinical spectrum of congenital disorder of glycosylation type Ih.
Marquardt et al., Münster, Germany. In Mol Genet Metab, 2009
ALG8 mutations expand the clinical spectrum of congenital disorder of glycosylation type Ih.
Impact of alginate overproduction on attachment and biofilm architecture of a supermucoid Pseudomonas aeruginosa strain.
Rehm et al., Palmerston North, New Zealand. In Appl Environ Microbiol, 2009
The supermucoid Pseudomonas aeruginosa strain PDO300Deltaalg8(pBBR1MCS-5:alg8) showed strongly impaired attachment compared with the respective mucoid or nonmucoid strains and formed a thicker biofilm with large extended mushroom-like microcolonies.
Clinical and molecular features of three patients with congenital disorders of glycosylation type Ih (CDG-Ih) (ALG8 deficiency).
Matthijs et al., In J Med Genet, 2004
ALG8 splice site mutations and missense mutations causing ALG8 deficiency in patients with congenital disorders of glycosylation type Ih.
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