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Armadillo repeat containing, X-linked 3

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Armadillo, lipocalin, CAN, ERM, Orf
Papers on ALEX3
The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.
Gardner et al., Worcester, United States. In J Biol Chem, 2009
Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3
DNA microarray analysis of region-specific gene expression in the mouse epididymis.
Cornwall et al., Lubbock, United States. In Biol Reprod, 2004
In addition, 123 clones exhibited 2-fold or higher expression in the initial segment, including Cres3, prostein, lipocalin 2, ALEX3, synaptotagmin-like 4, erm, and milk fat globule factor, whereas 216 clones, including elafin-like 1, lactotransferrin, Sin3B, zinc-finger protein 91, and membrane-type frizzled-related protein, showed 2-fold or higher expression in epididymal regions 2-5.
ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Nomura et al., Ibaraki, Japan. In Biochem Biophys Res Commun, 2001
ALEX1 shares significant homology with uncharacterized ORF KIAA0512 and putative protein product of unknown mRNA (GenBank AF211175), designated here as ALEX2 and ALEX3, respectively.
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