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Cytochrome P450, family 11, subfamily B, polypeptide 2

Aldosterone Synthase
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Angiotensin II, Renin, HAD, CAN, POLYMERASE
Papers on Aldosterone Synthase
Outer mitochondrial translocase, Tom22, is crucial for inner mitochondrial steroidogenic regulation in adrenal and gonadal tissues.
Bose et al., Edmonton, Canada. In Mol Cell Biol, Feb 2016
Although the absence of Tom22 did not inhibit mitochondrial import of P450scc and aldosterone synthase, it did inhibit 3βHSD2 expression.
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Rainey et al., Ann Arbor, United States. In J Clin Endocrinol Metab, Feb 2016
However, significant gaps remain in our understanding of the relationship between tumor aldosterone synthase (CYP11B2) expression and somatic mutation status.
Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.
Zhao et al., Nanning, China. In Technol Cancer Res Treat, Feb 2016
OBJECTIVE: This study was conducted to assess the relationship between aldosterone synthase CYP1A1 MspI gene polymorphism and prostate cancer risk using meta-analysis.
Retraction notice.
In J Renin Angiotensin Aldosterone Syst, Dec 2015
Zhong, Zhongliang Huang, Yong Wu, Zongpei Jiang, and Tian-Biao ZhouAssociation of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathyJournal of Renin-Angiotensin-Aldosterone System September 2015 16: 660-665, first published on August 20, 2014 doi:10.1177/1470320314524011.
An Update on Familial Hyperaldosteronism.
Scholl et al., Düsseldorf, Germany. In Horm Metab Res, Dec 2015
For many years, the genetics of familial hyperaldosteronism remained unknown, with the notable exception of glucocorticoid-remediable aldosteronism, due to unequal crossing over and formation of a chimeric 11β-hydroxylase/aldosterone synthase gene.
Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia.
Czerny et al., Poznań, Poland. In Eur J Obstet Gynecol Reprod Biol, Dec 2015
Aldosterone synthase (CYP11B2) is responsible for synthesis of aldosterone responsible for regulating blood pressure.
Medical therapy for Cushing's disease: adrenal steroidogenesis inhibitors and glucocorticoid receptor blockers.
Petersenn et al., Portland, United States. In Pituitary, Apr 2015
A new potent inhibitor of both aldosterone synthase and 11β-hydroxylase, following the completion of a phase II study LCI699 is being studied in a large phase III with promising results.
New approaches in the treatment of hypertension.
Schmieder et al., Jishou, China. In Circ Res, Apr 2015
New drug classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agonists of natriuretic peptide A and vasoactive intestinal peptide receptor 2, and a novel mineralocorticoid receptor antagonist are in phase II/III of development, while inhibitors of aminopeptidase A, dopamine β-hydroxylase, and the intestinal Na(+)/H(+) exchanger 3, agonists of components of the angiotensin-converting enzyme 2/angiotensin(1-7)/Mas receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or preclinical development.
Mineralocorticoids in the heart and vasculature: new insights for old hormones.
Hein et al., Freiburg, Germany. In Annu Rev Pharmacol Toxicol, 2014
For example, aldosterone synthase inhibitors such as LCI699 and the novel nonsteroidal MR antagonist BAY 94-8862 have been tested in clinical trials.
[Primary aldosteronism: new insights into familial forms].
Deinum et al., Rotterdam, Netherlands. In Ned Tijdschr Geneeskd, 2014
Familial aldosteronism type 1 is caused by a hybrid gene that codes for an ACTH-sensitive form of aldosterone synthase.
Efficacy and safety of LCI699 for hypertension: a meta-analysis of randomized controlled trials and systematic review.
Yang et al., New Orleans, United States. In Eur Rev Med Pharmacol Sci, 2014
OBJECTIVE: This study reviews the available data from randomized controlled trials on efficacy and safety of LCI699, a novel inhibitor of aldosterone synthase, as treatment of hypertension.
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP11B2 in metandienone metabolism.
New drugs, procedures, and devices for hypertension.
Esler et al., Paris, France. In Lancet, 2012
In this paper, we discuss two promising therapeutic alternatives for patients with resistant hypertension: novel drugs, including new pharmacological classes (such as vasopeptidase inhibitors and aldosterone synthase inhibitors) and new molecules from present pharmacological classes with additional properties in blood-pressure or metabolism pathways; and new procedures and devices, including stimulation of arterial baroreceptors and catheter-based renal denervation.
APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans.
Connell et al., Glasgow, United Kingdom. In Circ Res, 2012
Small molecule inhibition of the APEX1 repressor or treatment with small interfering RNA (siRNA) leads to increased CYP11B2 transcription.
Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways.
Kopprasch et al., Dresden, Germany. In Cell Tissue Res, 2012
This study demonstrates a novel insight into intracellular mechanism of VLDL-mediated aldosterone synthesis through transcriptional regulation of steroidogenic acute regulatory protein and Cyp11B2 expression.
[Effect of CYP11B2 gene -344T/C polymorphism on renin-angiotensin-aldosterone system activity and blood pressure response to hydrochlorothiazide].
Lu et al., Tangshan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
For female patients, no association was found between CYP11B2 -344T/C polymorphism and aldosterone level.
Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions.
Yang et al., Nanjing, China. In Cell Physiol Biochem, 2011
The G allele of CYP11B2 rs1799998 polymorphism is highly associated with coronary heart disease and severity of coronary atherosclerosis. Interaction of rs1799998, age, and smoking status is also associated with enhanced risk of coronary artery disease.
Disorders of steroid 11 beta-hydroxylase isozymes.
Pascoe et al., New York City, United States. In Endocr Rev, 1994
Unequal crossing over between the CYP11B genes can generate a duplicated chimeric gene with the transcriptional regulatory region of CYP11B1 but sufficient coding sequences from CYP11B2 so that the encoded enzyme has aldosterone synthase (i.e.
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Laidlaw et al., Salt Lake City, United States. In Nat Genet, 1992
Patients with glucocorticoid-remediable aldosteronism (GRA) from 12 kindreds possess chimaeric gene duplications arising from unequal crossing-over, fusing regulatory sequences of steroid 11 beta-hydroxylase to coding sequences of aldosterone synthase.
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension.
Lalouel et al., Salt Lake City, United States. In Nature, 1992
These abnormalities could result from ectopic expression of aldosterone synthase, which is normally expressed only in adrenal glomerulosa, in the adrenal fasciculata.
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