Mesoamerican Nephropathy or Global Warming Nephropathy?
Aurora, United States. In Blood Purif, Feb 2016
Potential mechanisms include the development of hyperosmolarity with the activation of the aldose reductase-fructokinase pathway in the proximal tubule leading to local injury and inflammation, and the possibility that renal injury may be the consequence of repeated uricosuria and urate crystal formation as a consequence of both increased generation and urinary concentration, similar to a chronic tumor lysis syndrome.
Update on genetics and diabetic retinopathy.
Miami, United States. In Clin Ophthalmol, 2014
Multiple smaller studies have investigated genotype-phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others.