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Galactose mutarotase

aldose 1-epimerase, Galactose mutarotase, Galactomutarotase
This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ACID, lacZ, UDPglucose 4-Epimerase, galactokinase, CAN
Papers on aldose 1-epimerase
Regulation of the Type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference.
Fineran et al., Dunedin, New Zealand. In Nucleic Acids Res, Aug 2015
Furthermore, we identified a galactose mutarotase, GalM, which reduced cas operon expression in a CRP- and CyaA-dependent manner.
Genomewide analysis of polysaccharides degrading enzymes in 11 white- and brown-rot Polyporales provides insight into mechanisms of wood decay.
Cullen et al., Tokyo, Japan. In Mycologia, 2013
Genes encoding aldose 1-epimerase (ALE), previously detected with CDH and cellulases in the culture filtrates, also were identified in white-rot genomes, suggesting a physiological connection between ALE, CDH, cellulase and possibly LPMO.
Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization.
Zhao et al., United States. In J Biotechnol, 2013
Here we investigate the functional role of aldose 1-epimerase (AEP) in engineered cellobiose utilization.
Analysis of tyrosine phosphorylation and phosphotyrosine-binding proteins in germinating seeds from Scots pine.
Gout et al., L'viv, Ukraine. In Plant Physiol Biochem, 2013
Using this approach, we purified two proteins of 10 and 43 kDa, which interacted specifically with pTyr-Sepharose and were identified by mass spectrometry as P. sylvestris defensin 1 (PsDef1) and aldose 1-epimerase (EC:,
A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study.
McMahon et al., In Mol Psychiatry, 2011
This study demonistrated that polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus.
Nitroproteins Identified in Human Ex-smoker Bronchoalveolar Lavage Fluid.
Desiderio et al., Lake Charles, United States. In Aging Dis, 2011
Eleven nitrotyrosine sites were identified in eight proteins, including progestin and adipoQ receptor family member III, zinc finger protein 432, proteasome subunit alpha type 2, NADH-ubiquinone oxidoreductase B14, slit homolog 1 protein, lysozyme, aldose 1-epimerase, and PTS system lactose-specific EIICB component.
Structure and function of the D-galactose network in enterobacteria.
Semsey et al., Bethesda, United States. In Mbio, 2010
Typically, genes are removed by deletions; however, in Yersinia pestis, the galactose mutarotase (galM) gene is inactivated by a single-base-pair deletion.
Crystallization and preliminary X-ray diffraction analysis of the putative aldose 1-epimerase YeaD from Escherichia coli.
Teng et al., Hefei, China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
Escherichia coli YeaD (ecYeaD) is suggested to be a member of the galactose mutarotase-like superfamily.
[Expression, purification, and crystallization of a novel galactose mutarotase from Thermoanaerobacter tengcongensis].
Wang et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2009
OBJECTIVE: To purify a novel galactose mutarotase (TTE1925) from Thermoanaerobacter tengcongensis for crystallization and X-ray diffraction.
Identification and functional analysis of the gene cluster for L-arabinose utilization in Corynebacterium glutamicum.
Yukawa et al., Kyoto, Japan. In Appl Environ Microbiol, 2009
Three l-arabinose-catabolizing genes, araA (encoding l-arabinose isomerase), araB (l-ribulokinase), and araD (l-ribulose-5-phosphate 4-epimerase), comprised the araBDA operon, upstream of which three other genes, araR (LacI-type transcriptional regulator), araE (l-arabinose transporter), and galM (putative aldose 1-epimerase), were present in the opposite direction.
Lack of aldose 1-epimerase in Hypocrea jecorina (anamorph Trichoderma reesei): a key to cellulase gene expression on lactose.
Karaffa et al., Debrecen, Hungary. In Proc Natl Acad Sci U S A, 2008
We therefore reasoned whether galactomutarotase [aldose 1-epimerase (AEP)] activity might limit lactose assimilation and thus influence cellulase formation.
Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC.
Paetzel et al., Canada. In J Biol Chem, 2008
Interestingly, YidCECP1 has significant structural similarity to galactose mutarotase from Lactococcus lactis, suggesting that this domain may have another function besides its role in membrane protein assembly.
Galactomutarotase and other galactose-related genes are rapidly induced by retinoic acid in human myeloid cells.
Ross et al., United States. In Biochemistry, 2008
Galactose mutarotase (GALM) has been well characterized at the protein level, but information is lacking on the regulation of GALM gene expression.
Galactose metabolism in yeast-structure and regulation of the leloir pathway enzymes and the genes encoding them.
Reece et al., Manchester, United Kingdom. In Int Rev Cell Mol Biol, 2007
In most organisms, including the yeast Saccharomyces cerevisiae, five enzymes are required to catalyze this conversion: a galactose mutarotase, a galactokinase, a galactose-1-phosphate uridyltransferase, a UDP-galactose-4-epimerase, and a phosphoglucomutase.
Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis.
Deeg et al., Germany. In J Proteome Res, 2007
Additionally, uveitic changes in the retina were accompanied by upregulation of aldose 1-epimerase, selenium-binding protein 1, alpha crystallin A chain, phosphatase 2A inhibitor (SET), and glial fibrillary acidic protein (GFAP), the latter indicating an involvement of retinal Mueller glial cells (RMG) in disease process.
New synchrotron radiation circular dichroism end-station on DISCO beamline at SOLEIL synchrotron for biomolecular analysis.
Maurizot et al., Orléans, France. In Biochim Biophys Acta, 2005
In order to show the kind of information accessible with this type of technique, we give an example: the conformational study of the galactose mutarotase from Escherichia coli, an enzyme involved in the galactose metabolism.
Molecular structure of human galactose mutarotase.
Holden et al., Madison, United States. In J Biol Chem, 2004
The enzyme is a monomer and has a similar structure to the Lactococcus lactis mutarotase.
Identification and characterisation of human aldose 1-epimerase.
Reece et al., Manchester, United Kingdom. In Febs Lett, 2003
Identification and characterisation of human aldose 1-epimerase.
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