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Aldo-keto reductase family 1, member C2

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: C-9, AKR1C3, ACID, CAN, HAD
Papers on AKR1C2
Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption.
Barbato et al., Napoli, Italy. In Int J Pharm, Feb 2016
Highly significant inverse linear relationships were observed between log P0Caco-2/MDCK and ΔlogkWIAM values from both IAM.PC.MG (r2 = 0.765) and IAM.PC.DD2 (r2 = 0.806) stationary phases whereas the relationships with either lipophilicity in n-octanol or logkWIAM values were very poor.
High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.
Zheng et al., Beijing, China. In J Biomol Screen, Jan 2016
We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2, both of which proved to be positive regulators in promoting metastasis in liver cancer.
Novel urease-negative basidiomycetous yeast, Trichosporon heliocopridis sp. nov., associated with dung beetles (Heliocopris bucephalus Fabricius) in the north of Thailand.
Akaracharanya et al., Bangkok, Thailand. In Int J Syst Evol Microbiol, Jan 2016
Five strains (DD1-1,DD2-33, DD4-11, DD5-15 and DD6-1) were selected as the representatives of this main group, whereeach of the five selectedstrains had been derivedfrom a different dung beetle collected innorthern Thailand.
Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer.
Bauer et al., Kiel, Germany. In Int J Clin Oncol, Dec 2015
We evaluated two aldo-keto reductases, AKR1C1 and AKR1C2, in stromal fibroblasts and carcinoma cells as prognostic factors in primary human breast cancer.
Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line.
Natsch et al., Dübendorf, Switzerland. In Toxicol Appl Pharmacol, Dec 2015
It is based on luciferase expression regulated by the antioxidant response element (ARE) of the aldoketoreductase 1C2 (AKR1C2) gene.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.
Hu et al., Guangzhou, China. In Chem Biol Interact, Nov 2015
Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases.
Association of parental history of type 2 diabetes with age, lifestyle, anthropometric factors, and clinical severity at type 2 diabetes diagnosis: results from the DD2 study.
Thomsen et al., Århus, Denmark. In Diabetes Metab Res Rev, Oct 2015
BACKGROUND: We investigated whether parental history of type 2 diabetes mellitus (T2D) is associated with age, lifestyle, anthropometric factors, and clinical severity at the time of T2D diagnosis.
Preparation of a biomimetic polyphosphorylcholine monolithic column for immobilized artificial membrane chromatography.
Jiang et al., Guangzhou, China. In J Chromatogr A, Sep 2015
Good correlation was observed between the retention on commercial IAM column (IAM.PC.DD2) and poly(MDPC-co-EDMA) monolith.
Updated survey of the steroid-converting enzymes in human adipose tissues.
Luu-The et al., Québec, Canada. In J Steroid Biochem Mol Biol, Mar 2015
Our work on 20α-HSD (AKR1C1), 3α-HSD type 3 (AKR1C2) and 17β-HSD type 5 (AKR1C3) allowed us to clarify the relevance of these enzymes for some aspects of adipose tissue function.
AEG-1 Promotes Metastasis Through Downstream AKR1C2 and NF1 in Liver Cancer.
Zheng et al., Beijing, China. In Oncol Res, 2014
Through deep sequencing and expression regulation analysis in liver cancer cells, we identified two novel factors, AKR1C2 (positive factor) and NF1 (negative factor), as the AEG-1 downstream players in the process of metastasis in liver cancer.
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children.
Sitaraman et al., In Clin Lab, 2014
Serum homocysteine levels were analyzed by enzyme immunoassay method using the kits provided by Axis-Shield Diagnostics Ltd (Dundee DD2 1XA, United Kingdom).
Understanding androgen action in adipose tissue.
Tomlinson et al., Birmingham, United Kingdom. In J Steroid Biochem Mol Biol, 2014
In particular, AKR1C2 and AKR1C3 are crucial in the regulation of local androgen bioavailability within adipose tissue.
Steroidogenesis of the testis -- new genes and pathways.
Pandey et al., Bern, Switzerland. In Ann Endocrinol (paris), 2014
However, recently found mutations in AKR1C2/4 genes in undervirilized 46,XY individuals have established a role for a novel, alternative, backdoor pathway for fetal testicular DHT synthesis.
AKR1C3 as a target in castrate resistant prostate cancer.
Penning et al., Philadelphia, United States. In J Steroid Biochem Mol Biol, 2013
Selective inhibition of AKR1C3 will be important, however, due to the presence of closely related isoforms, AKR1C1 and AKR1C2 that are also involved in androgen inactivation.
Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation.
Flück et al., Fribourg, Switzerland. In Mol Cell Endocrinol, 2013
The classic and backdoor pathways share many enzymes, but a 3α-reductase, AKR1C2, is unique to the backdoor pathway.
Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients.
Zhao et al., Shanghai, China. In Lung Cancer, 2012
DDH2 expression might be a potential predictor and monitor of cisplatin efficacy in advanced NSCLC patients.
Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes.
Tchernof et al., Québec, Canada. In Am J Physiol Endocrinol Metab, 2012
Data suggest that modulation of AKR1C2 by glucocorticoids (dexamethasone in this study) locally modifies exposure of adipose cells to endogenous androgens; thus, AKR1C2 activation/inactivation may be involved in regional fat deposition.
Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.
Myers et al., Oklahoma City, United States. In Reprod Sci, 2012
Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 and AKR1C2.
Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.
Penning et al., Philadelphia, United States. In Biochem J, 2011
role of AKR1C2 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway.
Residual interactions in unfolded bile acid-binding protein by 19F NMR.
Ropson et al., Penn Hills, United States. In Protein Sci, 2011
The folding initiation mechanism of human bile acid-binding protein (BABP) has been examined by (19) F NMR.
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