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Aryl hydrocarbon receptor interacting protein

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CaM, AGE
Papers on AIP
HIV-1 Env Glycoprotein Phenotype along with Immune Activation Determines CD4 T Cell Loss in HIV Patients.
Garg et al., El Paso, United States. In J Immunol, Feb 2016
Because HIV-1 Env glycoprotein has been implicated in bystander apoptosis, we cloned full-length Envs from plasma of viremic patients and tested their apoptosis-inducing potential (AIP).
Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.
Hodge et al., Chapel Hill, United States. In Addict Biol, Feb 2016
Intra-CeA infusion of the cell-permeable CaMKII peptide inhibitor myristolated autocamtide-2-related inhibitory peptide (m-AIP) dose-dependently reduced alcohol self-administration.
Serum Lipoproteins Are Critical for Pulmonary Innate Defense against Staphylococcus aureus Quorum Sensing.
Hall et al., Albuquerque, United States. In J Immunol, Feb 2016
Activation of agr and subsequent virulence factor expression is inhibited by apolipoprotein B, the structural protein of low-density lipoprotein, which binds and sequesters the secreted agr-signaling peptide (AIP).
Germline Prolactin Receptor Mutation is not a Major Cause of Sporadic Prolactinoma in Humans.
Binart et al., Paris, France. In Neuroendocrinology, Jan 2016
The main objective of this study was to detect germline PRLR mutations in patients with sporadic prolactinomas unrelated to AIP or MEN1 mutation.
Transcriptome analysis of genetic mechanism of growth curve inflection point using a pig model.
Zhu et al., Chengdu, China. In Genom Data, Dec 2015
Here, we report the differentially expressed gene pattern in pig longissimus dorsi among three typical time points of the growth curve, inflection point (IP), before inflection point (BIP) and after inflection point (AIP).
Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.
Beckers et al., Liège, Belgium. In Endocrinol Metab Clin North Am, Mar 2015
One important genetic cause of FIPA are inactivating mutations or deletions in the aryl hydrocarbon receptor interacting protein (AIP) gene.
Genetic mutations in sporadic pituitary adenomas--what to screen for?
Chanson et al., Le Kremlin-Bicêtre, France. In Nat Rev Endocrinol, 2015
Mutations in AIP (encoding aryl-hydrocarbon receptor-interacting protein) are the most frequently observed germline mutations.
Pharmacogenetics of antipsychotic-induced movement disorders as a resource for better understanding Parkinson's disease modifier genes.
Lerer et al., Ramat Gan, Israel. In Front Neurol, 2014
Antipsychotic-induced movement disorders are major side effects of antipsychotic drugs among schizophrenia patients, and include antipsychotic-induced parkinsonism (AIP) and tardive dyskinesia (TD).
Familial pituitary tumors.
Korbonits et al., London, United Kingdom. In Handb Clin Neurol, 2013
The genetic alterations responsible for the formation of familial pituitary syndromes include the MEN1 gene, responsible for about 80% of MEN1 cases, the regulatory subunit of the protein kinase A, PRKAR1A, responsible for about 70% of Carney complex cases, and AIP, the gene coding the aryl hydrocarbon receptor interacting protein, responsible for about 20% of FIPA cases.
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.
Karhu et al., Liège, Belgium. In Endocr Rev, 2013
The aryl hydrocarbon receptor interacting protein (AIP) gene has been identified as causing a pituitary adenoma predisposition of variable penetrance that accounts for 20% of FIPA families.
Familial Isolated Pituitary Adenoma
Korbonits et al., Madagascar. In Unknown Journal, 2012
Of these FIPA families, around 15-20% (3,4) have been identified to have mutations within the aryl hydrocarbon receptor interacting protein (AIP) gene, a tumour suppressor gene located at 11q13.
AIP expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of SSTR2 expression.
Gadelha et al., In Endocr Relat Cancer, 2012
AIP expression in sporadic somatotropinomas without AIP mutations is a predictor of acromegaly control with octreotide LAR treatment independent of SSTR2 expression
Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain.
Spanish MEN1 Group et al., Barakaldo, Spain. In Clin Endocrinol (oxf), 2012
Data show that MEN1 gene is the main target for genetic analysis in Multiple endocrine neoplasia type 1 (MEN1) syndrome, and suggest that in patients without MEN1 gene mutation, CDKN1B or AIP genes should also be tested.
Germline AIP mutations in apparently sporadic pituitary adenomas: prevalence in a prospective single-center cohort of 443 patients.
Chanson et al., Le Kremlin-Bicêtre, France. In J Clin Endocrinol Metab, 2012
genetic association studies in French population: Data suggest that mutations in AIP are associated with pituitary adenoma; study confirms very low prevalence of germline AIP mutations in patients with apparently sporadic pituitary adenomas.
WWP2 is an E3 ubiquitin ligase for PTEN.
Chen et al., Hyderābād, India. In Nat Cell Biol, 2011
In this study, by using a tandem affinity-purification approach, we have identified WWP2 (also known as atrophin-1-interacting protein 2, AIP-2) as a PTEN-interacting protein.
AIP mutation in pituitary adenomas in the 18th century and today.
Korbonits et al., London, United Kingdom. In N Engl J Med, 2011
Four contemporary Northern Irish families who presented with gigantism, acromegaly, or prolactinoma have the same mutation and haplotype associated with the mutated gene as a patient from the 18th century.
The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α.
Pongratz et al., Huddinge, Sweden. In Plos One, 2010
XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events.
The extraction of 3D shape in the visual system of human and nonhuman primates.
Orban, Leuven, Belgium. In Annu Rev Neurosci, 2010
Such neurons occur in CIP, AIP, TEs, and F5 (for first- or second-order disparity gradients), in MT/V5, in FST (for speed gradients), and in CIP and TEs (for texture gradients).
Identification of a novel antibody associated with autoimmune pancreatitis.
Puccetti et al., Verona, Italy. In N Engl J Med, 2009
RESULTS: Among the detected peptides, peptide AIP(1-7) was recognized by the serum specimens from 18 of 20 patients with autoimmune pancreatitis and by serum specimens from 4 of 40 patients with pancreatic cancer, but not by serum specimens from healthy controls.
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