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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

AGAP1, KIAA1099, A GAP, centaurin gamma-2, CENTG2
This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: GAP, p16, Actin, HAD, CAN
Papers on AGAP1
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
MacLennan et al., Adelaide, Australia. In Mol Psychiatry, Feb 2015
Ten de novo mutations in three previously identified disease genes (TUBA1A (n=2), SCN8A (n=1) and KDM5C (n=1)) and in six novel candidate CP genes (AGAP1, JHDM1D, MAST1, NAA35, RFX2 and WIPI2) were predicted to be potentially pathogenic for CP.
Novel mechanism coupling cyclic AMP-protein kinase A signaling and golgi trafficking via Gyp1 phosphorylation in polarized growth.
Wang et al., Singapore, Singapore. In Eukaryot Cell, 2014
A GAP-dead Gyp1 (Gyp1(R292K)) showed strong polarization similar to that seen with Gyp1(4E), indicating a role for the GAP activity.
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
Chen et al., Nanning, China. In Int J Clin Exp Med, 2014
There were 9 targeted genes which had been shown concurrently by at least 4 databases: AGAP1, AGK, BPTF, C16orf74, DACT1, LIX1L, RBMS3, ZNF706 and BMPER.
Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons.
Meyer et al., Stanford, United States. In Elife, 2013
A GAP domain in ArhGAP44 triggers local Rac-GTP hydrolysis, thus reducing actin polymerization required for filopodia formation.
The role of NADRIN, a Rho GTPase-activating protein, in the morphological differentiation of astrocytes.
Umeda et al., Tokyo, Japan. In J Biochem, 2013
A GAP activity-negative mutant or truncated forms of NADRIN failed to induce the stellation.
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
Randazzo et al., Bethesda, United States. In J Biol Chem, 2012
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
Population aging and the determinants of healthcare expenditures: the case of hospital, medical and pharmaceutical care in british columbia, 1996 to 2006.
Cunningham et al., Vancouver, Canada. In Healthc Policy, 2011
THERE IS A GAP BETWEEN RHETORIC AND REALITY CONCERNING HEALTHCARE EXPENDITURES AND POPULATION AGING: although decades-old research suggests otherwise, there is widespread belief that the sustainability of the healthcare system is under serious threat owing to population aging.
A GAP in our knowledge of vascular signaling in acute kidney injury.
Basile, Indianapolis, United States. In Kidney Int, 2011
Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments.
Plotkin, Indianapolis, United States. In Actual Osteol, 2011
Connexins are essential for the communication of cells among themselves and with their environment.
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.
Willman et al., Albuquerque, United States. In Blood, 2011
One unique cluster was characterized by high expression of distinct outlier genes AGAP1, CCNJ, CHST2/7, CLEC12A/B, and PTPRM; ERG DNA deletions; and 4-year relapse-free survival of 94.7% ± 5.1%, compared with 63.5% ± 3.7% for the cohort (P = .01).
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
Greengard et al., New York City, United States. In Embo J, 2010
The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.
Substrate specificities and activities of AZAP family Arf GAPs in vivo.
Casanova et al., Charlottesville, United States. In Am J Physiol Cell Physiol, 2008
AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6.
M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3.
Mosevitsky et al., Saint Petersburg, Russia. In J Neurochem, 2007
A GAP-43 fragment, lacking about forty N-terminal residues (named GAP-43-3), was produced by m-calpain-mediated cleavage of GAP-43 and inhibited m-calpain, but not micro-calpain.
Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology.
Satake et al., Sendai, Japan. In Cancer Sci, 2006
A GAP specific for Arf6 triggers the budding of endocytotic vesicles from the PM by inactivating GTP-bound Arf6.
The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.
Randazzo et al., Bethesda, United States. In J Cell Sci, 2005
The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes.
Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene.
Sheffield et al., Iowa City, United States. In Am J Med Genet B Neuropsychiatr Genet, 2005
CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism.
Ras-related GTPases and the cytoskeleton.
Hall, London, United Kingdom. In Mol Biol Cell, 1992
A GAP protein, perhaps intrinsic to the complex, would stimulate GTP hydrolysis allowing p21.GDP to dissociate.
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