Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice.
Hangzhou, China. In J Agric Food Chem, Feb 2016
Moreover, the hepatic gene expression analysis indicated that PPBN supplementation increased the expression levels of lipid-metabolism-related genes (AdipoR2, Cpt1a, Cpt1b, Acox1, PPARγ, Insig1, and Insig2) and FGF21-related genes (β-Klotho and FGFR1/2) but decreased the expression level of Fads2, Fas, and FGF21, suggesting that the protective effect of PPBNs might be associated with the induced fatty acid oxidation, decreased fatty acid biosynthesis, and alleviated FGF21 resistance.
Crystal structures of the human adiponectin receptors.
Yokohama, Japan. In Nature, May 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Adiponectin in asthma: implications for phenotyping.
Napoli, Italy. In Curr Protein Pept Sci, 2014
Interestingly, the three receptors AdipoR1, AdipoR2, and Tcadherin mediating adiponectin activity are expressed on lung cells mediating adiponectin beneficial effects.
Effects of interventions on adiponectin and adiponectin receptors.
Columbia, United States. In J Exerc Rehabil, 2014
Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures.
Cardiometabolic effects of adiponectin.
Boston, United States. In Best Pract Res Clin Endocrinol Metab, 2014
While progress has been made in identifying receptors essential for the metabolic actions of adiponectin (AdipoR1 and AdipoR2), few studies have examined the receptor-mediated signaling pathways in cardiovascular tissues.