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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Adenylate cyclase 5

adenylyl cyclase type V, adenylyl cyclase V, adenylate cyclase 5, Adenylyl Cyclase 5
enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, Gi, Phosphodiesterase, Angiotensin II
Papers on adenylyl cyclase type V
ADCY5-related dyskinesia: Broader spectrum and genotype-phenotype correlations.
Raskind et al., Seattle, United States. In Neurology, Jan 2016
OBJECTIVE: To investigate the clinical spectrum and distinguishing features of adenylate cyclase 5 (ADCY5)-related dyskinesia and genotype-phenotype relationship.
Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.
Dessauer et al., Jarash, Jordan. In Mol Pharmacol, Oct 2015
Adenylyl cyclase (AC) converts ATP into cyclic AMP (cAMP), an important second messenger in cell signaling.
Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata).
Dreyer et al., Tübingen, Germany. In Pigment Cell Melanoma Res, Sep 2015
Here, we report that the blond phenotype of the guppy is caused by a spontaneous mutation in the guppy ortholog of adenylate cyclase 5 (adcy5).
Ciliary adenylyl cyclases control the Hedgehog pathway.
Pons et al., Barcelona, Spain. In J Cell Sci, Sep 2015
Here, we show that adenylyl cyclase 5 and adenylyl cyclase 6 (AC5 and AC6, also known as ADCY5 and ADCY6, respectively) are the two isoforms most strongly expressed in cerebellar granular neuron precursors (CGNPs).
A de novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
Bahram et al., Strasbourg, France. In Mov Disord, Mar 2015
Here we identify adenylate cyclase 5 (ADCY5) as a likely new causal gene for early-onset chorea and dystonia.
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Blüher et al., Leipzig, Germany. In Plos One, 2014
Genome wide association studies revealed an association of the single nucleotide polymorphism rs11708067 within the ADCY5 gene--encoding adenylate cyclase 5--with increased type 2 diabetes (T2D) risk and higher fasting glucose.
ADCY5 couples glucose to insulin secretion in human islets.
Rutter et al., Pisa, Italy. In Diabetes, 2014
Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk.
Gene expression and β-adrenergic signaling are altered in hypoplastic left heart syndrome.
Sucharov et al., Aurora, United States. In J Heart Lung Transplant, 2014
Unique to those in the D-HLHS group was increased β-MHC and decreased α-MHC protein expression (MHC isoform switching), increased adenylyl cyclase 5 expression, and increased phosphorylation of the CaMK target site on phospholamban, threonine 17.
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Torkamani et al., Seattle, United States. In Ann Neurol, 2014
OBJECTIVE: To identify the cause of childhood onset involuntary paroxysmal choreiform and dystonic movements in 2 unrelated sporadic cases and to investigate the functional effect of missense mutations in adenylyl cyclase 5 (ADCY5) in sporadic and inherited cases of autosomal dominant familial dyskinesia with facial myokymia (FDFM).
Vidarabine is neither a potent nor a selective AC5 inhibitor.
Seifert, Hannover, Germany. In Biochem Pharmacol, 2014
Scientific interest in vidarabine has been recently renewed due to the fact that the compound exhibits beneficial effects in animal models of heart failure and cancer, replicating effects of the knockout of adenylyl cyclase 5 (AC5).
Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.
Deen et al., Nijmegen, Netherlands. In Am J Physiol Renal Physiol, 2014
AQP2 and adenylate cyclase 5/6 abundances were reduced in the inner medulla but increased in the cortex and outer medulla, in the absence of any sign of toxicity.
Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats.
LeSage et al., Minneapolis, United States. In Plos One, 2013
Compared to oxycodone self-administering control rats immunized with the carrier alone, rats vaccinated with the OXY-KLH immunogen showed increased levels of adenylate cyclase 5 (Adcy5) and decreased levels of early growth response protein 2 (Egr2) and the early immediate gene c-Fos in the striatum.
Anxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to μ-opioid receptor activation in rat nucleus accumbens.
de Gortari et al., Mexico. In Behav Brain Res, 2013
Anxiolytic effects of alcohol participate in the reinforcing properties of the drug, in which nucleus accumbens (NAcc) is implicated.
Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of action.
Törnquist et al., Turku, Finland. In Mol Endocrinol, 2012
This led to increased cAMP production, because inhibitory signals from calcium to adenylate cyclase 5/6 were decreased.
Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
Liggett et al., Baltimore, United States. In Am J Physiol Lung Cell Mol Physiol, 2011
The decrease in beta(2)-AR may account for additional relaxation impairment, given that there is no enhancement over nontransgenic after pertussis toxin, despite AC5 overexpression.
L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Florán et al., Mexico. In Neurobiol Dis, 2011
Increased expression of adenylyl cyclases V and VI is a major determinant of increased GABAergic transmission in the substantia nigra pars reticulata of animals in which L-DOPA induces severe dyskinesia.
Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
Mengod et al., Barcelona, Spain. In Brain Res, 2010
All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
Adenylyl cyclase type 5 protein expression during cardiac development and stress.
Vatner et al., Newark, United States. In Am J Physiol Heart Circ Physiol, 2009
Describe developmental expression of adenylyl cyclase 5.
An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.
Dessauer et al., Miami, United States. In J Biol Chem, 2009
The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy.
Regulation of gonadotropin-releasing hormone release by cyclic AMP signalling pathways.
Charles et al., San Francisco, United States. In Growth Horm Igf Res, 2001
Potential negative feedback pathways may decrease cAMP levels by inhibiting adenylyl cyclase V, and activating the phosphodiesterase, PDE4D3.
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