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Adenylate cyclase 2

adenylyl cyclase II, adenylate cyclase 2
Top mentioned proteins: V1a, CAN, Gi, beta2, HAD
Papers on adenylyl cyclase II
AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.
Cooper et al., Cambridge, United Kingdom. In Biochem J, 2013
AC2 (adenylate cyclase 2) is stimulated by activation of Gq-coupled muscarinic receptors through PKC (protein kinase C) to generate localized cAMP in HEK (human embryonic kidney)-293 cells.
Identification of novel germline polymorphisms governing capecitabine sensitivity.
Dolan et al., Chicago, United States. In Cancer, 2012
RESULTS: First, an intrapopulation GWAS of Caucasian individuals identified reference SNP 4702484 (rs4702484) (within adenylate cyclase 2 [ADCY2]) at a level reaching genome-wide significance (P = 5.2 × 10(-8) ).
Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
Dartt et al., Boston, United States. In Invest Ophthalmol Vis Sci, 2011
RESULTS: MECs expressed the MEC proteins α-smooth muscle actin, vimentin, α-actinin, and adenylyl cyclase II.
Real-time BRET assays to measure G protein/effector interactions.
Hébert et al., Montréal, Canada. In Methods Mol Biol, 2010
Here we describe protocols for these assays focusing on the basal and ligand-stimulated interaction between tagged Gβγ subunits and adenylyl cyclase II.
Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos.
Latham et al., Philadelphia, United States. In Am J Physiol Cell Physiol, 2010
The most striking effect of mPN strain of origin on gene expression was on adenylate cyclase 2 (Adcy2).
Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
Hébert et al., Montréal, Canada. In Cell Signal, 2008
Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Chung et al., Boston, United States. In Endocr Relat Cancer, 2008
FEV, adenylate cyclase 2 (ADCY2), nuclear receptor subfamily 4, group A, member 2 (NR4A2), and growth arrest and DNA-damage-inducible, beta (GADD45b) were the most highly up-regulated genes in the malignant group of PNETs.
Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility.
Wieland et al., Hamburg, Germany. In Mol Endocrinol, 2007
By quantitative real-time PCR and overexpression of the recombinant protein, we demonstrate that an up-regulation of the Gbetagamma-stimulated adenylyl cyclase II during pregnancy is most likely responsible for this switch.
Signalling complexes associated with adenylyl cyclase II are assembled during their biosynthesis.
Hébert et al., Montréal, Canada. In Cell Signal, 2007
We have previously demonstrated that adenylyl cyclase II (ACII) interacts with beta2-adrenergic receptors and heterotrimeric G proteins as part of a pre-assembled signalling complex.
Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein.
Burns et al., New York City, United States. In J Neurobiol, 2006
In the present work, using striatum from chronic morphine-treated rats, we isotyped the Gbeta within Gs and Go heterotrimers that coupled to MOR and compared these to the Gbeta isotype of the Gbetagamma that interacted with adenylyl cyclase II or IV after chronic morphine treatment.
Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.
Albert et al., Ottawa, Canada. In Mol Pharmacol, 2006
Most mutants retained agonist binding and were tested for Gbetagamma signaling to adenylyl cyclase II or phospholipase C and Galphai coupling to detect constitutive and agonist-induced Gi/Go coupling.
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation.
Hamm et al., Nashville, United States. In J Biol Chem, 2005
Receptor for Activated C Kinase 1 (RACK1), a novel G betagamma-interacting protein, selectively inhibits the activation of a subclass of G betagamma effectors such as phospholipase C beta2 (PLCbeta2) and adenylyl cyclase II by direct binding to G betagamma (Chen, S., Dell, E. J., Lin, F., Sai, J., and Hamm, H. E. (2004) J. Biol.
Chronic morphine acts via a protein kinase Cgamma-G(beta)-adenylyl cyclase complex to augment phosphorylation of G(beta) and G(betagamma) stimulatory adenylyl cyclase signaling.
Gintzler et al., New York City, United States. In Brain Res Mol Brain Res, 2005
Chronic morphine augments protein kinase C (PKC) phosphorylation of G(beta), which enhances the potency of G(betagamma) to stimulate adenylyl cyclase II (ACII) activity.
RACK1 regulates specific functions of Gbetagamma.
Hamm et al., Nashville, United States. In J Biol Chem, 2004
Moreover, binding of RACK1 to Gbetagamma results in inhibition of Gbetagamma-mediated activation of phospholipase C beta2 and adenylyl cyclase II.
Phosphorylation of Gbeta is augmented by chronic morphine and enhances Gbetagamma stimulation of adenylyl cyclase activity.
Gintzler et al., New York City, United States. In Brain Res Mol Brain Res, 2003
The present study investigates the PKC isoform selectivity of Gbeta phosphorylation and the consequences thereof on the ability of Gbetagamma to stimulate adenylyl cyclase II (ACII).
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
Bourne et al., San Francisco, United States. In Nature, 1992
Coexpression of mutationally active alpha s with adenylyl cyclase II converted agonists that act through 'inhibitory' receptors (coupled to Gi) into stimulators of cAMP synthesis.
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