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Adenylate kinase 2

Adenylate Kinase, AK2
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, fibrillin-1
Papers using Adenylate Kinase antibodies
Papers on Adenylate Kinase
Sequential Closure of Loop Structures Forms the Folding Nucleus during the Refolding Transition of the Escherichia coli Adenylate Kinase Molecule.
Haas et al., Worcester, United States. In Biochemistry, Feb 2016
Previously, it was shown that at least three long loops in the Escherichia coli adenylate kinase (AK) molecule close within the first 5 ms of folding of AK, while the main global folding transition occurs in a time regime of seconds.
Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmd(mdx) Mice.
McMichael et al., Providence, United States. In Dose Response, Oct 2015
The highest 3 concentrations had a significant effect on lowering contractile-induced injury as measured by a reduction in the release of adenylate kinase.
The Atomistic Mechanism of Conformational Transition of Adenylate Kinase Investigated by Lorentzian Structure-Based Potential.
Lee et al., Seoul, South Korea. In J Chem Theory Comput, Aug 2015
To test the validity of this approach, we have investigated the conformational transition of adenylate kinase (ADK).
Thiamine triphosphate: a ubiquitous molecule in search of a physiological role.
Wins et al., Liège, Belgium. In Metab Brain Dis, 2014
Though it was long thought that ThTP was synthesized by a ThDP:ATP phosphotransferase, more recent studies indicate that it can be synthesized by two different enzymes: (1) adenylate kinase 1 in the cytosol and (2) FoF1-ATP synthase in brain mitochondria.
[Human adenylate kinases - classification, structure, physiological and pathological importance].
Hetmann et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
Adenylate kinase (AK, EC is a ubiquitous phosphotransferase which catalyzes the reversible transfer of high-energy β - and γ-phosphate groups between nucleotides.
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.
Yegutkin, Turku, Finland. In Crit Rev Biochem Mol Biol, 2014
Along with "classical" inactivating ectoenzymes, recent data provide evidence for the co-existence of a counteracting ATP-regenerating pathway comprising the enzymes of the adenylate kinase (AK) and nucleoside diphosphate kinase (NDPK/NME/NM23) families and ATP synthase.
High-resolution modeling of protein structures based on flexible fitting of low-resolution structural data.
Tekpinar et al., Buffalo, United States. In Adv Protein Chem Struct Biol, 2013
We have demonstrated our method using adenylate kinase as a test case which undergoes a large open-to-close conformational change.
Efficacy of Tenofovir 1% Vaginal Gel in Reducing the Risk of HIV-1 and HSV-2 Infection.
Major et al., Baile Átha Luain, Ireland. In Clin Med Insights Womens Health, 2013
Tenofovir is an NRTI that is phosphorylated by adenylate kinase to tenofovir diphosphate, which in turn competes with deoxyadeosine 5'-triphosphate for incorporation into newly synthesized HIV DNA.
Exploring the Dynamic Functional Landscape of Adenylate Kinase Modulated by Substrates.
Wang et al., Changchun, China. In J Chem Theory Comput, 2013
Adenylate kinase (ADK) has been explored widely, through both experimental and theoretical studies.
Multiscale Coarse-Graining via Normal Mode Analysis.
Lu et al., Singapore, Singapore. In J Chem Theory Comput, 2012
In the practical aspect, the method is suitable for conformational analyses of large biomacromolecules and calculations of mechanical properties of biomaterials, which is demonstrated by the studied systems including an amyloid dimer, lysozyme and adenylate kinase proteins, and the S2 subdomain of myosin.
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Corvera et al., Worcester, United States. In J Biol Chem, 2011
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Genetic defects in severe congenital neutropenia: emerging insights into life and death of human neutrophil granulocytes.
Klein, Hannover, Germany. In Annu Rev Immunol, 2010
Deficiency of the mitochondrial proteins HAX1 and AK2 cause premature apoptosis of myeloid progenitor cells associated with dissipation of the mitochondrial membrane potential, whereas mutations in ELA2/ELANE and G6PC3 are associated with signs of increased endoplasmic reticulum stress.
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.
Muslin et al., Saint Louis, United States. In J Mol Cell Cardiol, 2010
Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha.
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
Wang et al., Dallas, United States. In Cell, 2010
ENTPD5, together with cytidine monophosphate kinase-1 and adenylate kinase-1, constitute an ATP hydrolysis cycle that converts ATP to AMP, resulting in a compensatory increase in aerobic glycolysis known as the Warburg effect.
Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing.
Seo et al., Seoul, South Korea. In Nat Genet, 2010
Whole-genome sequencing data from a reference genome (NA10851, with 28.3x coverage) and two Asian genomes (AK1, with 27.8x coverage and AK2, with 32.0x coverage) were used to transform the relative copy number information obtained from array CGH experiments into absolute copy number values.
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.
Cavazzana-Calvo et al., Paris, France. In Nat Genet, 2009
Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified.
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.
Schwarz et al., Ulm, Germany. In Nat Genet, 2009
The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis.
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Deville-Bonne et al., Paris, France. In Nucleosides Nucleotides Nucleic Acids, 2008
The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP kinases 2
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