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Adenosylmethionine decarboxylase 1

Adenosylmethionine Decarboxylase, S-adenosylmethionine decarboxylase, AdoMetDC, SAMDC
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: ornithine decarboxylase, HAD, ACID, CAN, AdoMet
Papers using Adenosylmethionine Decarboxylase antibodies
Activation of rat liver S-adenosylmethionine decarboxylase by putrescine and 2-substituted 1,4 butanediamines
Ealick Steven E. et al., In Biochemistry, 1988
... The wild type AdoMetDC and mutants were purified using a Ni-NTA (Qiagen) affinity column under native ...
Papers on Adenosylmethionine Decarboxylase
Cotton S-adenosylmethionine decarboxylase-mediated spermine biosynthesis is required for salicylic acid- and leucine-correlated signaling in the defense response to Verticillium dahliae.
Ma et al., Baoding, China. In Planta, Feb 2016
MAIN CONCLUSION: Cotton S-adenosylmethionine decarboxylase-, rather than spermine synthase-, mediated spermine biosynthesis is required for salicylic acid- and leucine-correlated signaling in the defense response to Verticillium dahliae.
Spatial and temporal distribution of genes involved in polyamine metabolism during tomato fruit development.
Delis et al., Athens, Greece. In Plant Physiol Biochem, Feb 2016
Moreover, the expression of genes coding for enzymes involved in higher polyamine metabolism, including Spermidine synthase (SPDS), Spermine synthase (SPMS), S-adenosylmethionine decarboxylase (SAMDC) and Polyamine oxidase (PAO), were studied.
Expression profiles of sugarcane under drought conditions: Variation in gene regulation.
Almeida et al., Arapiraca, Brazil. In Genet Mol Biol, Dec 2015
Total RNA was extracted from leaves and the expression of SAMDC, ZmPIP2-1 protein, ZmTIP4-2 protein, WIP protein, LTP protein, histone H3, DNAj, ferredoxin I, β-tubulin, photosystem I, gene 1 and gene 2 was analyzed by quantitative real-time PCR (RT-PCR).
Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.
Claessens et al., Leuven, Belgium. In Endocrinology, Dec 2015
Expression of the muscle-specific, androgen-responsive genes S-adenosylmethionine decarboxylase and myostatin was decreased by orchidectomy and restored by GTx-024 and DHT in control mice, whereas the expression was low and unaffected by androgen status in satARKO.
Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone.
Xu et al., Burlingame, United States. In J Virol, Dec 2015
Here we demonstrate that methylglyoxal-bis-guanylhydrazone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decreases HIV expression in monocytes and macrophages.
Screening of potential targets in Plasmodium falciparum using stage-specific metabolic network analysis.
Roy et al., Vallabh Vidyanagar, India. In Mol Divers, Nov 2015
The results obtained indicate that S-adenosylmethionine decarboxylase/ornithine decarboxylase, a bifunctional enzyme required for polyamine synthesis, is important for the Plasmodium cell growth in the absence of exogenous polyamines.
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Rajam et al., New Delhi, India. In Tumour Biol, Sep 2015
In this study, specific silencing of the expression of three genes of PA biosynthesis pathway, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC), and spermidine synthase (SPDSYN) was achieved using RNA interference in MCF 7 breast cancer cell line.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Colotti et al., Roma, Italy. In Mini Rev Med Chem, 2014
The enzymes, belonging to the spermidine metabolism, i.e. arginase (ARG), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase (SpdS), trypanothione synthetase (TryS or TSA), trypanothione reductase (TryR or TR), tryparedoxin peroxidase (TXNPx), deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are promising targets for the development of new drugs against leishmaniasis.
A tumour suppressor network relying on the polyamine-hypusine axis.
Lowe et al., New York City, United States. In Nature, 2012
Among the new tumour suppressors are adenosylmethionine decarboxylase 1 (AMD1) and eukaryotic translation initiation factor 5A (eIF5A), two genes associated with hypusine, a unique amino acid produced as a product of polyamine metabolism through a highly conserved pathway.
AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells.
Vardy et al., Singapore, Singapore. In Genes Dev, 2012
Amd1 is a major regulator of embryonic stem cell self-renewal and that its essential role lies in its regulation of Myc levels within the cell
Regulation and function of polyamines in African trypanosomes.
Phillips et al., Dallas, United States. In Trends Parasitol, 2012
Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which catalyzes a key step in the biosynthesis of the polyamine spermidine, is activated by dimerization with an inducible protein termed prozyme.
Regulation of polyamine metabolism by translational control.
Merali et al., Philadelphia, United States. In Amino Acids, 2012
In this review, we present an overview of the translational control mechanisms of the proteins in the polyamine pathway, including ornithine decarboxylase (ODC), ODC antizyme, S-adenosylmethionine decarboxylase and spermidine/spermine N(1) acetyltransferase, highlighting the areas where more research is needed.
Genetic variant of AMD1 is associated with obesity in urban Indian children.
Bharadwaj et al., Delhi, India. In Plos One, 2011
Genetic variant of AMD1 is associated with obesity.
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.
Heby et al., Pretoria, South Africa. In Biochem J, 2011
These properties include prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, co-expression of ODC (ornithine decarboxylase) and AdoMetDC activities in a single protein in plasmodia, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism in trypanosomatids.
Polyamines, androgens, and skeletal muscle hypertrophy.
MacLean et al., Melbourne, Australia. In J Cell Physiol, 2011
The rate-limiting polyamine biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase, are essential for mammalian development, with knockout of the genes encoding these enzymes, Odc1 and Amd1, causing early embryonic lethality in mice.
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase.
Hölttä et al., Helsinki, Finland. In Int J Biochem Cell Biol, 2011
Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants.
Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.
Cheng et al., Boston, United States. In Cancer Biol Ther, 2010
Decreased AMD1 is associated with prostate cancer.
Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Ealick et al., Ithaca, United States. In Biochemistry, 2009
determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223
Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality, and vine life.
Mattoo et al., Beltsville, United States. In Nat Biotechnol, 2002
We expressed a yeast S-adenosylmethionine decarboxylase gene (ySAMdc; Spe2) fused with a ripening-inducible E8 promoter to specifically increase levels of the polyamines spermidine and spermine in tomato fruit during ripening.
Polyamines as targets for therapeutic intervention.
Pegg et al., Madison, United States. In Annu Rev Pharmacol Toxicol, 1994
Inhibitors of S-adenosylmethionine decarboxylase also have potential as treatments of these diseases.
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