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Adenosine A2B receptor

adenosine A2B receptor, adenosine A2b receptor in, Adora2b, adenosine A2B receptor on
regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: A2B, V1a, A2A, ACID, HAD
Papers on adenosine A2B receptor
Stimulation of gastric acid secretion by rabbit parietal cell A2B adenosine receptor activation.
Ochoa et al., Leioa, Spain. In Am J Physiol Cell Physiol, Jan 2016
The renewed interest in the adenosine A2B receptor (A2BR) subtype can be traced by studies in which the introduction of new genetic and chemical tools has widened the pharmacological and structural knowledge of this receptor as well as its potential therapeutic use in cancer and inflammation- or hypoxia-related pathologies.
Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
Auchampach et al., Milwaukee, United States. In Purinergic Signal, Dec 2015
We utilized zinc-finger nuclease technology to create A2BAR gene (Adora2b)-disrupted rats on the Dahl salt-sensitive (SS) genetic background.
Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.
Eltzschig et al., München, Germany. In J Immunol, Sep 2015
To address this hypothesis, we exposed mice with tissue-specific deletion of Adora2b to ALI, utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation.
The effects of A2B receptor modulators on vascular endothelial growth factor and nitric oxide axis in chronic cyclosporine nephropathy.
Thaker et al., Ānand, India. In J Pharmacol Pharmacother, Jul 2015
INTRODUCTION: To investigate the actions of adenosine A2B receptor modulators on VEGF and NO levels in CsA nephropathy.
Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway.
Yang et al., Charlottesville, United States. In Oxid Med Cell Longev, 2014
BACKGROUND: Activation of the adenosine A2B receptor (A2BR) can reduce myocardial ischemia/reperfusion (IR) injury.
In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver.
Carlström et al., Stockholm, Sweden. In Front Physiol, 2014
This study aimed at investigating the acute effects of inorganic nitrate on glucose and insulin signaling in adenosine A2B receptor knockout mice (A(-/-) 2B), a genetic mouse model of impaired metabolic regulation.
The role of adenosine signaling in sickle cell therapeutics.
Linden et al., Milwaukee, United States. In Hematol Oncol Clin North Am, 2014
Adenosine signaling through the adenosine A2B receptor (A2BR) may be detrimental in SCD.
Anesthetic cardioprotection: the role of adenosine.
Eckle et al., Aurora, United States. In Curr Pharm Des, 2013
As such, the adenosine A2b receptor was shown to be the only one of the adenosine receptors whose cardiac expression is induced by ischemia in both mice and humans and whose function is implicated in ischemic pre- or post-conditioning.
A role for period 2 in cardioprotection.
Jaswal et al., In Cell Metab, 2012
Eckle et al. (2012) now show that signaling through adenosine receptor 2b (Adora2b) stabilizes a circadian rhythm protein, period 2 (Per2), resulting in the stabilization of hypoxia-inducible factor-1α (HIF-1α), upregulation of glycolysis, and cardioprotection from ischemia.
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Eltzschig et al., Aurora, United States. In Nat Med, 2012
In a wide search for adenosine receptor A2b (Adora2b)-elicited cardioadaptive responses, we identified the circadian rhythm protein period 2 (Per2) as an Adora2b target.
2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.
Gillespie et al., Pittsburgh, United States. In Am J Physiol Heart Circ Physiol, 2011
2',3'-cAMP inhibits proliferation of vascular smooth muscle cells from the aorta and coronary arteries. This effect is due in part to metabolism of 2',3'-cAMP to adenosine, with engagement of the A2B receptor.
Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.
Krieg et al., Greifswald, Germany. In Basic Res Cardiol, 2011
the present study demonstrates that activation of A(2B)AR is strongly cardioprotective in rat heart and suppresses transition pores in isolated cardiomyocytes
Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
Akiba et al., Los Angeles, United States. In J Pharmacol Exp Ther, 2010
Endogenously produced luminal surface adenosine increases HCO3- secretion in an intact intestinal epithelium in vivo through the activation of A2B receptors.
Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor.
Auchampach et al., Milwaukee, United States. In J Mol Cell Cardiol, 2010
The A(2B)AR may contribute to the later stages of ischemic preconditioning dependent on the induction of stress-responsive genes.
Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation.
Navar et al., New Orleans, United States. In Am J Physiol Renal Physiol, 2010
A(2A) and A(2B) receptors are functionally expressed in juxtamedullary afferent arterioles. The powerful vasodilating action of adenosine predominantly involves A(2B) receptor activation, which counteracts A(1) receptor-mediated vasoconstriction.
The adenosine a2b receptor: its role in inflammation.
Rees et al., Cardiff, United Kingdom. In Endocr Metab Immune Disord Drug Targets, 2008
Investigations into the role of the adenosine A2b receptor have been enigmatic due to the lack of good selective high affinity agonists and antagonists.
Structure-affinity relationships of adenosine A2B receptor ligands.
Ijzerman et al., Leiden, Netherlands. In Med Res Rev, 2006
Many selective and high affinity agonists and antagonists have been developed for the adenosine A(1), A(2A), and A(3) receptors.
Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression.
Peng et al., Indianapolis, United States. In Int J Oncol, 2005
In addition, we have uncovered several GPCRs, such as neuropeptide receptors, adenosine A2B receptor, P2Y purinoceptor, calcium-sensing receptor and metabotropic glutamate receptors, that are expressed at a significantly higher level in some cancer tissue and may play a role in cancer progression.
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation.
Tessier-Lavigne et al., San Francisco, United States. In Science, 2001
Activation of the adenosine A2B receptor, proposed to contribute to netrin effects on axons, is not required for rat commissural axon outgrowth or Xenopus spinal axon attraction to netrin-1.
Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.
Mehlen et al., Villeurbanne, France. In Nature, 2000
Here we show that DCC interacts with the membrane-associated adenosine A2b receptor, a G-protein-coupled receptor that induces cAMP accumulation on binding adenosine.
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