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ADAM metallopeptidase with thrombospondin type 1 motif, 15

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ADAMTS, thrombospondin-1, aggrecanase, Aggrecan, ADAMTS9
Papers on ADAMTS15
Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.
Fox et al., Blacksburg, United States. In J Comp Neurol, Apr 2015
We therefore explored the expression pattern of two aggrecan-degrading ADAMTS family members, ADAMTS15 and ADAMTS4, in the hippocampus and neocortex.
Genetic study of intracranial aneurysms.
Koizumi et al., Kyoto, Japan. In Stroke, Mar 2015
Replicate association studies revealed that only p.E133Q in ADAMTS15 was aggregated in the familial IA cases (odds ratio, 5.96; 95% confidence interval, 2.40-14.82;
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
Edwards et al., Norwich, United Kingdom. In Int J Cancer, Mar 2015
We previously demonstrated that decreased ADAMTS15 expression correlated with a worse clinical outcome in mammary carcinoma (e.g., Porter et al., Int J Cancer 2006;118:1241-7).
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.
McCulloch et al., Australia. In J Biol Chem, 2014
ADAMTS15, a member of this clade, was recently identified as a putative tumor suppressor gene in colorectal and breast cancer.
Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression.
Chiocchia et al., In Arthritis Res Ther, 2013
Four selected genes were validated by q RT-PCR: ADAMTS15, CITED2, F13A1 and SELL.
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.
Hirohata et al., Ankara, Turkey. In Biomed Res Int, 2013
ADAMTS1, ADAMTS9, and ADAMTS15 were detected by Western blot in Adamts4-/- mice' spinal cords after SCI.
Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.
McCulloch et al., Geelong, Australia. In J Biol Chem, 2013
Relevant ADAMTS genes, chief among them Adamts5 and Adamts15, were expressed both in developing embryonic muscle and differentiating C2C12 cells.
Transcriptomic Profiling of Medial Temporal Lobe Epilepsy.
Pandey et al., Bengaluru, India. In J Proteomics Bioinform, 2012
We also identified molecules such as BACH2 and ADAMTS15, which are already known to be associated with epilepsy.
Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle: metalloproteinase involvement in follicle rupture.
Hennebold et al., Beaverton, United States. In Endocrinology, 2011
Quantitative real-time PCR validation revealed increased mRNA levels for matrix metalloproteinase (MMP1, MMP9, MMP10, and MMP19) and a disintegrin and metalloproteinase with thrombospondin-like repeats (ADAMTS1, ADAMTS4, ADAMTS9, and ADAMTS15) family members, the cysteine protease cathepsin L (CTSL), the serine protease urokinase-type plasminogen activator (PLAU), and the aspartic acid protease pepsinogen 5 (PGA5).
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
Buttle et al., Sheffield, United Kingdom. In Cancer Invest, 2010
ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Kähäri et al., Iceland. In Clin Cancer Res, 2010
In addition, the results identify several novel HNSCC-associated proteinases, including ADAM8, ADAM9, ADAM17, ADAM28, ADAMTS1, ADAMTS8, and ADAMTS15.
Protective roles of matrix metalloproteinases: from mouse models to human cancer.
Samuels et al., Oviedo, Spain. In Cell Cycle, 2009
Parallel studies have extended these findings to other MMP-related metalloproteinases such as ADAMTS15, which has been found to be genetically inactivated in human colorectal cancer.
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.
López-Otín et al., Oviedo, Spain. In Cancer Res, 2009
ADAMTS15 may be target of inactivating mutations in human cancer.
Submicroscopic deletions of 11q24-25 in individuals without Jacobsen syndrome: re-examination of the critical region by high-resolution array-CGH.
Rajcan-Separovic et al., Vancouver, Canada. In Mol Cytogenet, 2007
Their rearrangements facilitate the refinement of the JBS critical region and suggest that a) deletion of at least 3 of the 4 platelet function critical genes (ETS-1, FLI-1 and NFRKB and JAM3) is necessary for thrombocytopenia; b) one of the critical regions for heart abnormalities (conotruncal heart defects) may lie within 129.03 - 130.6 Mb; c) deletions of KCNJ1 and ADAMTS15 may contribute to the renal anomalies in Jacobsen Syndrome; d) the critical region for MRI abnormalities involves a region from 124.6 - 129.03 Mb.
Expression of ADAMs and their inhibitors in sputum from patients with asthma.
Cataldo et al., Liège, Belgium. In Mol Med, 2006
mRNA levels of ADAM-8, ADAM-9, ADAM-12, TIMP-1, and TIMP-3 were significantly increased, whereas mRNA levels coding for ADAMTS-1, ADAMTS-15, and RECK were significantly decreased in patients with asthma compared with control patients.
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Edwards et al., Norwich, United Kingdom. In Int J Cancer, 2006
ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma
The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.
Eaton et al., Sheffield, United Kingdom. In Prostate, 2005
negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer
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