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ADAM metallopeptidase with thrombospondin type 1 motif, 8

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ADAMTS, thrombospondin-1, POLYMERASE, aggrecanase, Aggrecan
Papers on ADAMTS-8
Cyclic stretch induced gene expression of extracellular matrix and adhesion molecules in human periodontal ligament cells.
Zhang et al., Shanghai, China. In Arch Oral Biol, Mar 2015
These differentially expressed genes included genes encoding cell-cell adhesion molecules (CD44, ICAM1), cell-matrix adhesion molecules (ITGA5, ITGA6, ITGAL, ITGB2, SPP1), basement membrane constituents (SPARC, TNC), collagens and ECM constituents (COL5A1, COL11A1, FN1), ECM proteases (ADAMTS1, ADAMTS8, MMP8) and inhibitors (TIMP1), as well as other adhesion-related molecules (CTGF, CTNND2, TGFBI, CLEC3B).
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
Lein et al., Paris, France. In Mol Psychiatry, Feb 2015
Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin; Adamts8 and Adamts15 belonging to the class of metzincin proteases involved in reshaping the perineuronal net (PNN) and Mme encoding for Neprilysin, the enzyme degrading amyloid β-peptides.
A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers.
Azzoli et al., Tokyo, Japan. In J Thorac Oncol, 2014
The primary objective was to determine an association between promoter methylation of 10 individual tumor suppressor genes (CDKN2A, CDH13, RASSF1, APC, MGMT, GSTP1, DAPK1, WIF1, SOCS3, and ADAMTS8) and recurrence-free survival (RFS), with the secondary objectives of determining association with overall survival (OS), and relation to clinical or pathologic features.
The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
Tao et al., Hong Kong, Hong Kong. In Mol Cancer Res, 2014
Through refining a loss of heterozygosity locus at 11q25 by array-CGH, we identified ADAMTS8 as a novel candidate tumor suppressor gene.
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
Christensen et al., Oslo, Norway. In Plos One, 2013
RESULTS: We discovered that myocardial mRNA and protein levels of ADAMTS1 and -4, and mRNA levels of versican, aggrecan, and ADAMTS8 increased after AB, and TNF-α and IL-1β synergistically increased mRNA of versican and ADAMTS4 in NCM and NFB and secretion of ADAMTS4 from NCM.
Gonadal steroids regulate the expression of aggrecanases in human endometrial stromal cells in vitro.
Leung et al., Vancouver, Canada. In J Cell Mol Med, 2013
P4, DHT but not E2 have regulatory effects on ADAMTS-8, -9 and -5 expression.
DNA methylation signatures identify biologically distinct thyroid cancer subtypes.
Fraga et al., Oviedo, Spain. In J Clin Endocrinol Metab, 2013
Among the genes indentified, we show that 4 potential tumor suppressor genes (ADAMTS8, HOXB4, ZIC1, and KISS1R) and 4 potential oncogenes (INSL4, DPPA2, TCL1B, and NOTCH4) are frequently regulated by aberrant methylation in primary thyroid tumors.
Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells.
Ozlü et al., Bolu, Turkey. In Eur Rev Med Pharmacol Sci, 2013
AIM: To investigate the effects of hypericin which is obtained from the plant Hypericum perforatum on the expression and the regulation of ADAMTS8 and ADAMTS9 genes in MCF7 breast cancer cells and on the viability of these cells.
Anti-angiogenic properties of ADAMTS-4 in vitro.
Buttle et al., Sheffield, United Kingdom. In Int J Exp Pathol, 2012
ADAMTS-1 and ADAMTS-8 have been reported to be anti-angiogenic.
The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction.
Cui et al., Jinan, China. In Biomed Pharmacother, 2011
INTRODUCTION: ADAMTS4 and ADAMTS8 are proteases involved in ECM proteolysis and antiangiogenesis, but little is known about their expression and function in myocardial infarction (MI).
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
van Duijn et al., Leicester, United Kingdom. In Nat Genet, 2011
near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3
Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study.
Pinet et al., Lille, France. In J Proteome Res, 2010
We found a restricted number of proteins differentially expressed between AAA and PAO patients: TIMP-3, ADAMTS5, and ADAMTS8 that differ significantly in plasma of AAA patients compared to PAO patients, as found in the macrophages.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Kähäri et al., Iceland. In Clin Cancer Res, 2010
In addition, the results identify several novel HNSCC-associated proteinases, including ADAM8, ADAM9, ADAM17, ADAM28, ADAMTS1, ADAMTS8, and ADAMTS15.
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
Eriksson et al., Stockholm, Sweden. In Atherosclerosis, 2008
ADAMTS-4 expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours.
Walker et al., Liverpool, United Kingdom. In Br J Cancer, 2006
Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis.
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Edwards et al., Norwich, United Kingdom. In Int J Cancer, 2006
ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
Fosang et al., Melbourne, Australia. In Nature, 2005
However, they are not thought to be the primary aggrecanases because ADAMTS1 null mice are not protected from experimental arthritis, and cleavage by ADAMTS8 and 9 is highly inefficient.
METH-2 silencing and promoter hypermethylation in NSCLC.
Liloglou et al., Liverpool, United Kingdom. In Br J Cancer, 2004
Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease.
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
LaVallie et al., Cambridge, United States. In Matrix Biol, 2004
Ability of ADAMTS-8 to cleave aggrecan at aggrecanase-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8)
Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors.
Ortega et al., Los Angeles, United States. In Ann N Y Acad Sci, 1998
To identify novel proteins with such a domain, we have cloned two cDNAs (METH-1 and METH-2) which also have antiangiogenic properties.
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