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ADAM metallopeptidase domain 30

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Notch2, Insulin, p16, ADAMTS9, WFS1
Papers on ADAM30
Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial.
Peter et al., New York City, United States. In Pharmacogenomics J, Feb 2015
We identified 27 NOTCH2/ADAM30 and 8 C2CD4B variants conferring a 40-57% increase in glucose during the first 6 h of infusion (P<5.96
A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population.
Racoubian et al., Manama, Bahrain. In Diabetes Res Clin Pract, 2013
We genotyped by the allelic discrimination method 19 SNPs in/near ADAM30, NOTCH2, THADA, TMEFF2, COL8A1, ADAMTS9-AS2, WFS1, JAZF1, SLC30A8, KCNQ1, LOC387761, ALX4, TSPAN8, FTO, and HNF1.
Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.
Indian Migration Study Group et al., New Delhi, India. In Diabetologia, 2012
Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of -0.06 (p = 0.04), 0.05 (p = 0.05), -0.08 (p = 0.01) and -0.08 (p = 0.02), respectively.
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
Jia et al., Shanghai, China. In Plos One, 2008
But no significant association was detected between SNPs from WFS1, FTO, JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and type 2 diabetes.
Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression.
Nelson et al., Seattle, United States. In Biochem Biophys Res Commun, 1999
We have isolated cDNAs encoding two novel members of this family, ADAM29 and ADAM30 which show testis-specific expression.
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