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Acyl-Coenzyme A oxidase 1, palmitoyl

acyl-CoA oxidase
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, PPAR, catalase, HAD, CAN
Papers on acyl-CoA oxidase
Expression of lipid metabolism-related proteins in breast phyllodes tumors.
Koo et al., In Neoplasma, Feb 2016
Immunohistochemical staining for lipid metabolism-related proteins, namely hormone-sensitive lipase (HSP), perilipin 2, fatty-acid-binding proteins 4 (FABP4), Carnitine palmitoyltransferase-1 (CPT-1), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed, and the immunohistochemical staining results were analyzed with respect to clinicopathologic parameters.
PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats.
Robertson et al., Iowa City, United States. In Toxicol Sci, Jan 2016
Additionally, transcript levels of Pparα, and its targets acyl-CoA oxidase (Acox1) and hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), were also downregulated, indicating changes in peroxisomal fatty acid oxidation and ketogenesis.
Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer.
Sharma-Walia et al., North Chicago, United States. In Oncotarget, Dec 2015
Surprisingly, the expression of lipogenic pathway genes including SREBP-1c (sterol regulatory element-binding protein-1c), HMG-CoA synthase, SPTLC1 (serine palmitoyltransferase long-chain), and Acyl-CoA oxidase (ACO) decreased with a concurrent increase in fatty acid oxidation genes such as CPT-1a (carnitine palmitoyltransferase 1a) and SREBP-2 (Sterol regulatory element-binding protein-2).
Fish oil diet in pregnancy and lactation reduces pup weight and modifies newborn hepatic metabolic adaptations in rats.
Herrera et al., Madrid, Spain. In Eur J Nutr, Dec 2015
Liver lipoprotein lipase activity and mRNA expression, and the expression of carnitine palmitoyl transferase I, acyl-CoA oxidase and 3-hydroxy 3-methyl glutaryl-CoA synthase increased more at birth in pups of the FD group, but the expression of sterol regulatory element binding protein-1c and Δ6-desaturase mRNA was lower in the FD group.
Role of adenosine 5'-monophosphate-activated protein kinase in α-linolenic acid-induced intestinal lipid metabolism.
Wang et al., Hangzhou, China. In Br J Nutr, Oct 2015
ALA also increased mRNA expression of genes (carnitine palmitoyltransferase 1a, acyl-CoA oxidase 1, medium-chain acyl-CoA dehydrogenase, cytochrome P450 4A10 and pyruvate dehydrogenase kinase isoenzyme 4a) involved in intestinal lipid oxidation and mRNA expression of TAG synthesis-related genes (monoacylglycerol O-acyltransferase 2, diacylglycerol O-acyltransferases 1 and 2) in WT mice.
Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer.
Koo et al., Seoul, South Korea. In Plos One, 2014
METHODS: Immunohistochemical staining for lipid metabolism-related proteins [fatty acid synthase (FASN), hormone-sensitive lipase (HSL), carnitine palmitoyltransferase IA (CPT-1A), acyl-CoA oxidase 1 (ACOX1), fatty acid binding protein 4 (FABP4,) and perilipin 1 (PLIN1)] was performed using a tissue microarray of 149 cases of metastatic breast cancer (bone metastasis = 39, brain metastasis = 37, liver metastasis = 21, and lung metastasis = 52).
Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice.
Liu et al., Beijing, China. In Nutr Metab (lond), 2014
Fatty acid β-oxidation related genes, on the other hand, such as peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets.
Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.
Jin et al., Iksan, South Korea. In Eur J Med Res, 2014
Peroxisomal function was analyzed by BODIPY staining, and gene expression of PMP70 and acyl-CoA oxidase 1, by real-time PCR.
PPARα/HNF4α interplay on diversified responsive elements. Relevance in the regulation of liver peroxisomal fatty acid catabolism.
Latruffe et al., Dijon, France. In Curr Drug Metab, 2012
While mitochondria breaks down fatty acids with short, medium and long carbon chains, peroxisomes are involved in the catabolism of very long and branched chain fatty acids, which are degraded by three enzymes: acyl-CoA oxidase, multifunctional enzyme and thiolase enzyme.
Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.
Lizard et al., Dijon, France. In Neuroscience, 2012
Our data support a link between oxidative stress and the deficiency of Abcd1 or Acox1 peroxisomal proteins.
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.
Hirth et al., London, United Kingdom. In Hum Mol Genet, 2012
Data show that alternative oxidase (AOX) fully restores ATP levels and prevents dopaminergic neurodegeneration.
Regulation of lipid disorders by ethanol extracts from Zingiber zerumbet in high-fat diet-induced rats.
Liu et al., Taiwan. In Food Chem, 2012
HFD-induced reductions in the hepatic proteins of peroxisome proliferator-activated receptor (PPAR) α, acyl-CoA oxidase (ACO) and cytochrome P450 isoform 4A1 (CYP4A1) were reversed by EEZZ.
Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice.
Reddy et al., Chicago, United States. In Am J Pathol, 2011
progressive PPARalpha- and p8-mediated ER stress contribute to the hepatocarcinogenesis in ACOX1(-/-) mice
Molecular characterization, polymorphism of the ACOX1 gene and association with ultrasound traits in Bos taurus.
Wang et al., China. In Genet Mol Res, 2010
molecular characterization of the ACOX1 gene; identified one SNP and investigated its association in 7 Bos taurus populations; the A1865C SNP of ACOX1 is significantly associated with ultrasound backfat thickness and ultrasound marbling score in cattle
Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].
Cherkaoui-Malki et al., Dijon, France. In Lab Invest, 2010
Data show that human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse.
[PPAR and NASH].
Aoyama et al., Chinju, South Korea. In Nihon Rinsho, 2006
For example, in mice lacking acyl-CoA oxidase gene, which developed NASH spontaneously, the absence of PPARalpha prevented the development of NASH.
Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase.
Valley et al., College Station, United States. In Arch Biochem Biophys, 2005
Recent structural analyses show that NAO is homologous to the acyl-CoA dehydrogenase and acyl-CoA oxidase families of enzymes.
Acyl-CoA dehydrogenases and acyl-CoA oxidases. Structural basis for mechanistic similarities and differences.
Miura et al., Milwaukee, United States. In Eur J Biochem, 2004
In addition, the structure of peroxisomal acyl-CoA oxidase II from rat liver is compared to that of medium chain acyl-CoA dehydrogenase, and the structural basis for their different oxidative half reactions is discussed.
Genetic-dependency of peroxisomal cell functions - emerging aspects.
Cherkaoui Malki et al., Dijon, France. In J Cell Mol Med, 2003
This paper reviews aspects concerning the genetic regulation of the expression of the well studied peroxisomal genes including those of fatty acid beta-oxidation enzymes; acyl-CoA oxidase, multifunctional enzyme and thiolase from different tissues and species.
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
Evans et al., Los Angeles, United States. In Nature, 1992
6) form a heterodimer that activates acyl-CoA oxidase gene expression in response to either clofibric acid or the retinoid X receptor-alpha ligand, 9-cis retinoic acid, an all-trans retinoic acid metabolite; simultaneous exposure to both activators results in a synergistic induction of gene expression.
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