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ARP3 actin-related protein 3 homolog

Actin-Related Protein 3, Arp3
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Arp2, CAN, fibrillin-1, Eps8
Papers using Actin-Related Protein 3 antibodies
Evidence for common structural determinants of human immunodeficiency virus type 1 coreceptor activity provided through functional analysis of CCR5/CXCR4 chimeric coreceptors.
Trkola Alexandra, In PLoS Pathogens, 2000
... The siRNA resistant mutations were generated in Arp3 based on sequences obtained from Santa Cruz Biotechnology, Inc (SCBT, Santa Cruz, ...
Papers on Actin-Related Protein 3
Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference?
Garaicoechea et al., Buenos Aires, Argentina. In Rev Argent Microbiol, Oct 2015
Two sets of anti-RVA VHHs have been developed: ARP1-ARP3; 2KD1-3B2.
Actin, actin-related proteins and profilin in diatoms: a comparative genomic analysis.
Menzel et al., Bonn, Germany. In Mar Genomics, Oct 2015
All diatom species examined here lack ARP2 and ARP3 proteins, suggesting that diatoms are not capable of forming the Arp2/3 complex, which is essential in most eukaryotes for actin filament branching and plus-end dynamics.
Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.
Cheng et al., Hong Kong, Hong Kong. In Endocrinology, Aug 2015
This disruptive effect on the tight junction barrier was mediated by a loss of actin microfilament bundling and actin polymerization capability mediated by changes in the localization of branched actin-inducing protein Arp3 (actin-related protein 3), and actin bundling proteins Eps8 (epidermal growth factor receptor pathway substrate 8) and palladin, thereby disrupting cell adhesion.
Plasma IgG autoantibody against actin-related protein 3 in liver fluke Opisthorchis viverrini infection.
Pinlaor et al., Khon Kaen, Thailand. In Parasite Immunol, Jul 2015
Seven protein spots were recognized by IgG autoantibodies, and the highest matching scored protein was actin-related protein 3 (ARP3).
rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat sertoli cells. An in vitro study.
Cheng et al., Hong Kong, Hong Kong. In Endocrinology, May 2015
These changes are mediated by a reorganization of actin microfilaments, which was triggered by a redistribution of activated actin-related protein 3 (Arp3) as well as changes in Arp3-neuronal Wiskott-Aldrich Syndrome protein (N-WASP) interaction.
ARP2/3-Mediated Actin Nucleation Associated With Symbiosome Membrane Is Essential for the Development of Symbiosomes in Infected Cells of Medicago truncatula Root Nodules.
Fedorova et al., Wageningen, Netherlands. In Mol Plant Microbe Interact, May 2015
To clarify the role of the ARP2/3 complex in the development of infected cells and symbiosomes, we analyzed the pattern of actin microfilaments and the functional role of ARP3 in Medicago truncatula root nodules.
EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
Cheng et al., Hong Kong, Hong Kong. In Endocrinology, Feb 2015
Second, EB1 knockdown perturbed actin organization via its effects on the branched actin polymerization-inducing protein called Arp3 (actin-related protein 3), perturbing microfilament bundling capability based on a biochemical assay, thereby causing microfilament truncation and misorganization, disrupting the function of the vehicle.
Large scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer.
Yang et al., Shanghai, China. In Sci Rep, 2014
Another two cell migration related proteins vitronectin (VTN) and actin-related protein (ARP3) were also proved to be up-regulated by both mass spectrometry (MS) based quantification results and Western blotting.
The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway.
Doublet et al., Mobile, United States. In Mbio, 2014
LegK2 phosphorylates the ARPC1B and ARP3 subunits of the ARP2/3 complex.
The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.
Gomez-Cambronero et al., Dayton, United States. In J Biol Chem, 2014
Importantly, PA directly binds to actin-related protein 3 (Arp3) at EC50 = 22 nm, whereas control phosphatidylcholine did not bind.
Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block.
Hozák et al., Praha, Czech Republic. In Histochem Cell Biol, 2014
Overexpression of EN-actin causes increase in the nuclear levels of actin-related protein 3 (Arp3).
Co-expression of anti-rotavirus proteins (llama VHH antibody fragments) in Lactobacillus: development and functionality of vectors containing two expression cassettes in tandem.
Marcotte et al., Stockholm, Sweden. In Plos One, 2013
In this study, we have developed co-expression vectors enabling Lactobacillus paracasei BL23 to produce two VHH fragments against rotavirus (referred to as anti-rotavirus proteins 1 and 3, ARP1 and ARP3) as secreted and/or surface displayed products.
The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis.
Hetherington et al., Bristol, United Kingdom. In Plant Cell, 2012
The work indicates that regulation of actin reassembly through ARP2/3 complex activity is crucial for stomatal regulation.
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis.
Bear et al., Chapel Hill, United States. In Cell, 2012
Cells depleted of Arp2/3 complex cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis).
cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.
Lemichez et al., Nice, France. In Cell Host Microbe, 2011
Anthrax edema toxin induced transendothelial cell tunnels are resealed by MIM via Arp2/3-driven actin polymerization.
Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.
Li et al., Kansas City, United States. In Nat Cell Biol, 2011
Show that the Arp2/3 complex localizes to the oocyte cortical cap in a Ran-GTPase-dependent manner and nucleates actin filaments in the cortical cap and a cytoplasmic actin network.
SCAR mediates light-induced root elongation in Arabidopsis through photoreceptors and proteasomes.
Blancaflor et al., Ardmore, United States. In Plant Cell, 2011
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex.
Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3.
Mruk et al., New York City, United States. In Biochem J, 2011
In the present review, we critically evaluate these and other findings in the literature as they relate to the restricted temporal and spatial expression of two actin regulatory proteins, namely Eps8 (epidermal growth factor receptor pathway substrate 8) and Arp3 (actin-related protein 3), which regulate these events.
Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe.
Chang et al., New York City, United States. In Nat Cell Biol, 2001
Patches move more slowly or stop when actin polymerization is attenuated by Latrunculin A or in arp3 and cdc3 (profilin) mutants.
The actin-related proteins.
Mooseker et al., New Haven, United States. In Curr Opin Cell Biol, 1996
In the past year, different arps have been linked to functions mediated by actin filaments (arp2 and arp3), microtubules (arp1) and the structural elements of chromatin (arp4 and arp6).
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