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Acyl-CoA synthetase long-chain family member 3

ACSL3, ACS3, FACL3, acyl-CoA synthetase long-chain family member 3
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, ACS4, HAD, CAN, AGE
Papers on ACSL3
Lipid-rich bovine serum albumin improves the viability and hatching ability of porcine blastocysts produced in vitro.
Yoshioka et al., Ibaraki, Japan. In J Reprod Dev, Dec 2015
The mRNA levels of enzymes involved in fatty acid metabolism and β-oxidation (ACSL1, ACSL3, CPT1, CPT2 and KAT) in Day-7 blastocysts were significantly upregulated by the addition of LR-BSA.
Eicosapentaenoic Acid Prevents Saturated Fatty Acid-Induced Vascular Endothelial Dysfunction: Involvement of Long-Chain Acyl-CoA Synthetase.
Imada et al., In J Atheroscler Thromb, Dec 2015
ACSL inhibition and siRNA-mediated ACSL3 knockdown suppressed the PA-induced increase in the expression of adhesion molecule, cytokines, and inflammatory protein, and ACSL inhibition suppressed the enhancement of p65 phosphorylation.
Veterinary Medicine and Omics (Veterinomics): Metabolic Transition of Milk Triacylglycerol Synthesis in Sows from Late Pregnancy to Lactation.
Liao et al., Guangzhou, China. In Omics, Oct 2015
Robust upregulation with high relative mRNA abundance was evident during lactation for genes associated with FA uptake (VLDLR, LPL, CD36), FA activation (ACSS2, ACSL3), and intracellar transport (FABP3), de novo FA synthesis (ACACA, FASN), FA elongation (ELOVL1), FA desaturation (SCD, FADS1), TAG synthesis (GPAM, AGPAT1, LPIN1, DGAT1), lipid droplet formation (BTN2A1, XDH, PLIN2), and transcription factors and nuclear receptors (SREBP1, SCAP, INSIG1/2).
Gender differences in symptom predictors associated with acute coronary syndrome: A prospective observational study.
Heidari et al., Aydın, Turkey. In Int Emerg Nurs, Aug 2015
P = 0.044) were significantly associated with the diagnosis of ACS 3.78, 2.72 and 1.87 times more than in women having these symptoms, respectively.
Microarray analysis of differentially expressed genes regulating lipid metabolism during melanoma progression.
Sudhakar et al., In Indian J Biochem Biophys, Apr 2015
Results showed that melanomas upregulated PPARGC1A transcription factor and its target genes regulating synthesis of fatty acids (SCD) and complex lipids (FABP3 and ACSL3).
Short-term complete submergence of rice at the tillering stage increases yield.
Zhou et al., Yangzhou, China. In Plos One, 2014
Compared with the control group, the 1/1 group showed significant increases in yield, seed-setting rate, photosynthetically efficient leaf area, and OS-ACS3 gene expression after 1 d of submergence.
Ethylene is Involved in Brassinosteroids Induced Alternative Respiratory Pathway in Cucumber (Cucumis sativus L.) Seedlings Response to Abiotic Stress.
Lin et al., Chengdu, China. In Front Plant Sci, 2014
Furthermore, transcription level of ethylene signaling biosynthesis genes including ripening-related ACC synthase1 (C S ACS1), ripening-related ACC synthase2 (C S ACS2), ripening-related ACC synthase3 (C S ACS3), 1-aminocyclopropane-1-carboxylate oxidase1 (C S ACO1), 1-aminocyclopropane-1-carboxylate oxidase2 (C S ACO2), and C S AOX were increased after BL treatment.
Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes.
Milagro et al., Pamplona, Spain. In Cell Mol Biol (noisy-le-grand), 2014
Special mention deserves acyl-CoA synthetase long-chain family member 3 (ACSL3) and endothelial lipase (LIPG), which were downregulated by this stilbene and have been previously associated with fatty acid synthesis and obesity in other tissues.
Gene expression of fatty acid transport and binding proteins in the blood-brain barrier and the cerebral cortex of the rat: differences across development and with different DHA brain status.
Guesnet et al., Jouy-le-Moutier, France. In Prostaglandins Leukot Essent Fatty Acids, 2014
In control rats, all the genes were expressed at the BBB level (P14 to P60), the mRNA levels of FABP5 and ACSL3 having the highest values.
Cryotolerance and global gene-expression patterns of Bos taurus indicus and Bos taurus taurus in vitro- and in vivo-produced blastocysts.
Landim-Alvarenga et al., Botucatu, Brazil. In Reprod Fertil Dev, 2014
The lipid metabolism-related genes were upregulated in Simmental (AUH and ELOVL6) and IVP (ACSL3 and ACSL6) blastocysts.
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.
Zhang et al., Nanjing, China. In J Neurosci, 2014
We report here that dAcsl, the Drosophila ortholog of ACSL4 and ACSL3, inhibits synaptic growth by attenuating BMP signaling, a major growth-promoting pathway at neuromuscular junction (NMJ) synapses.
Dynamic changes of the ethylene biosynthesis in 'Jonagold' apple.
Nicolai et al., Leuven, Belgium. In Physiol Plant, 2014
Transcription of ACS3 was found ethylene independent and was triggered upon warming of CA-stored apples.
Genome wide association study identifies 20 novel promising genes associated with milk fatty acid traits in Chinese Holstein.
Qiao et al., Beijing, China. In Plos One, 2013
Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1.
Molecular cloning of the goose ACSL3 and ACSL5 coding domain sequences and their expression characteristics during goose fatty liver development.
Pan et al., China. In Mol Biol Rep, 2013
It has been demonstrated that ACSL3 and ACSL5 play important roles in fat metabolism.
Increased IL-4 mRNA expression and poly-aromatic hydrocarbon concentrations from children with asthma.
Alokail et al., Riyadh, Saudi Arabia. In Bmc Pediatr, 2013
The aim of this study was to compare the mRNA expression patterns of Interleukin (IL)-4, interferon (IFN)-γ and Acyl Co A long chain 3 (ACSL3) in peripheral blood leukocytes of children with and without asthma.
The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.
Füllekrug et al., Heidelberg, Germany. In J Lipid Res, 2012
role of N-terminal region of acyl-CoA synthetase 3 in its function and localization on lipid droplets
ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells.
Lai et al., Tainan City, Taiwan. In J Cell Biochem, 2011
expression of ACSL3 was induced by endoplasmic reticulum stress
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.
Yamaguchi et al., Chiba, Japan. In J Cell Sci, 2010
Results suggest that initiation of Golgi export of Lyn involves association of ACSL3 with the Lyn C-lobe, which is exposed to the molecular surface in an open conformation.
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells.
Nebb et al., Oslo, Norway. In J Lipid Res, 2010
Results suggest that liver X receptors play a regulatory role in fatty acid metabolism by direct regulation of ACSL3 in human placental trophoblast cells.
Long chain acyl-CoA synthetase-3 is a molecular target for peroxisome proliferator-activated receptor delta in HepG2 hepatoma cells.
Liu et al., Palo Alto, United States. In J Biol Chem, 2010
ACSL3 is a novel molecular target of PPARdelta in HepG2 cells; there is a regulatory mechanism for ACSL3 transcription in liver tissue
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