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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Trypsin, ZP2, TRIM36
Papers on Acrosin
Acrosin-binding protein (ACRBP) in the testes of stallions.
Yoon et al., Sangju, South Korea. In Anim Reprod Sci, Dec 2015
Acrosin Binding Protein (ACRBP) is specifically localized in the acrosome of germ cells of several species, including mice, pigs, guinea pigs, and humans.
In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues.
Ogawa et al., Yokohama, Japan. In Plos One, 2014
We used two lines of transgenic mice, Acrosin-GFP and Gsg2-GFP, which carry the marker GFP gene specific for meiotic and haploid cells, respectively.
A comprehensive proteomic approach to identifying capacitation related proteins in boar spermatozoa.
Pang et al., Ansŏng, South Korea. In Bmc Genomics, 2013
RESULT: We identified Ras-related protein Rab-2, Phospholipid hydroperoxide glutathione peroxidase (PHGPx) and Mitochondrial pyruvate dehydrogenase E1 component subunit beta (PDHB) that were enriched before-capacitation, and NADH dehydrogenase 1 beta subcomplex 6, Mitochondrial peroxiredoxin-5, (PRDX5), Apolipoprotein A-I (APOA1), Mitochondrial Succinyl-CoA ligase [ADP-forming] subunit beta (SUCLA2), Acrosin-binding protein, Ropporin-1A, and Spermadhesin AWN that were enriched after-capacitation (>3-fold) by 2-DE and ESI-MS/MS.
DNA immunization against proacrosin impairs fertility in male mice.
Veaute et al., Santa Fe de la Vera Cruz, Argentina. In Am J Reprod Immunol, 2012
DNA immunization against proacrosin impairs fertility in male mice.
Differentiation of murine male germ cells to spermatozoa in a soft agar culture system.
Huleihel et al., Beersheba, Israel. In Asian J Androl, 2012
Immunofluorescence and real-time PCR were used to analyse specific markers expressed in undifferentiated and differentiated spermatogonia (Vasa, Dazl, OCT-4, C-Kit, GFR-α-1, CD9 and α-6-integrin), meiotic cells (LDH, Crem-1 and Boule) and post-meiotic cells (Protamine-1, Acrosin and SP-10).
Mice lacking two sperm serine proteases, ACR and PRSS21, are subfertile, but the mutant sperm are infertile in vitro.
Baba et al., Tsukuba, Japan. In Biol Reprod, 2010
These data demonstrate that the trypsinlike protease activity of ACR and PRSS21 is essential for the process of sperm penetration through the cumulus matrix and zona pellucida in vitro
Presumptive germ cells derived from mouse pluripotent somatic cell hybrids.
Kerkis et al., São Paulo, Brazil. In Differentiation, 2009
Expression of meiotic and postmeiotic GC-specific genes such as Haprin, Acrosin, Scyp1, Scyp3 and Stra-8 were also detected.
Effects of tributyltin on epididymal function and sperm maturation in mice.
Wang et al., Xiamen, China. In Environ Toxicol Pharmacol, 2009
Acrosin and lactate dehydrogenase-X isoenzyme (LDH-X) activities from the cauda epididymal spermatozoa showed a dose-dependent decrease in the TBT groups.
Adaptive evolution of gamete-recognition proteins in birds.
Ellegren et al., Uppsala, Sweden. In J Mol Evol, 2008
We therefore sequenced six genes (ZP1, ZP2, ZP4, ZPAX, CD9, and Acrosin) encoding gamete-recognition proteins in several bird species to test for positive selection.
In vitro differentiation of male mouse embryonic stem cells into both presumptive sperm cells and oocytes.
Kerkis et al., São Paulo, Brazil. In Cloning Stem Cells, 2006
It seems that gamete-like cell formation occurs in the correct manner based on the expression of early and late GC-specific genes such as Oct-4, Mvh, Stella, Dazl, Piwil 2, Pdrd 1, Rex 14, Rnf 17, Bmp8b, Acrosin, Stra-8, Haprin, LH-R, Gdf9, Zp3, Zp2, Sycp1, and Sycp3.
Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC.
Vazquez-Levin et al., Buenos Aires, Argentina. In Fertil Steril, 2005
Binding sites for recombinant human zona pellucida (ZP) glycoproteins located at the N- and C-termini of proacrosin reveal a key role of the proenzyme in the interaction.
Semen characteristics: Advancement in andrological assessment.
Kriplani et al., New Delhi, India. In Indian J Clin Biochem, 2005
In this review, the recent advancement in investigation procedures has been analyzed which are very important in clinical practice to (a) evaluate the sperm fertilizing ability (Acrosin, aniline blue, HOS), (b) characterization of male accessory sex glands secretions (Fructose, alpha-glucosidase, PSA) and (c) the management of azoospermic patients.
Inhibition of rabbit sperm acrosomal enzymes by gossypol.
Srivastava et al., Athens, United States. In Mol Reprod Dev, 1995
Acrosin, Azocoll proteinase, neuraminidase, and arylsulfatase were significantly inhibited or completely inactivated by 12-76 microM gossypol.
Two forms of basic trypsin-like arginine amidases in boar sperm.
Akihama et al., Tokyo, Japan. In Arch Androl, 1993
Acrosin and newly detected basic arginine amidase were separated from boar sperm by affinity adsorption using lima bean trypsin inhibitor (LBTI) and aprotinin columns, respectively.
Mouse proacrosin gene: nucleotide sequence, diploid expression, and chromosomal localization.
Engel et al., Göttingen, Germany. In Genomics, 1991
Acrosin is a serine proteinase located in the acrosome of the sperm in a zymogen form, proacrosin.
Nucleotide sequence and exon-intron organization of the human proacrosin gene.
Engel et al., Göttingen, Germany. In Eur J Biochem, 1990
Acrosin is a serine proteinase and located in a zymogen form, proacrosin, in the acrosome of the sperm.
Male infertility associated with round-headed acrosomeless spermatozoa.
Bleau et al., Montréal, Canada. In Fertil Steril, 1988
(2) Acrosin activity was only 1% to 6% of that found in sperm obtained from fertile donors.
Induction of acrosomal reaction in sperm with ionophore A23187 and calcium.
White et al., In Arch Androl, 1981
Acrosin was lost from ram, rabbit, and human sperm after treatment with ionophore plus calcium.
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