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Tyrosine kinase, non-receptor, 2

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cdc42, CAN, Akt, V1a, Rhodopsin
Papers using ACK antibodies
Persistent malignant stem cells in del(5q) myelodysplasia in remission
Jacobsen Sten Eirik W. et al., In Nature Immunology, 2009
... ACKNOWLEDGEMENTSWe thank the Biomedical Services at Oxford University ...
Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain
Conte Maria R. et al., In Nucleic Acids Research, 2009
... ACKNOWLEDGEMENTSWe are grateful to the MRC Biomedical NMR Centre, Mill Hill ...
Silver-catalyzed aldehyde olefination using siloxy alkynes
Kozmin Sergey A. et al., In Nature Chemistry, 2009
... AcknowledgementsThis work was funded by the National Institutes of Health (P50 GM086145) and the Chicago Biomedical Consortium with support from ...
Cortactin in tumor invasiveness
Hotchin Neil A., In PLoS ONE, 2007
... Control and human targeted siRNA for ACK1 (5′-AAGGUCAGCAGCACCCACUAU-3′) were purchased from Thermo Scientific.
Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism
Kadowaki Makoto et al., In Clinical and Developmental Immunology, 2006
... AcknowledgmentsThe authors would like to thank Dr Syed Faisal Zaidi (Department of Biological and Biomedical Sciences, Aga Khan University, ...
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Papers on ACK
Whole-Exome Sequencing in Familial Parkinson Disease.
Foroud et al., Houston, United States. In Jama Neurol, Feb 2016
Two of these genes (TNK2 and TNR) also had rare variants that were predicted to be damaging in the replication cohort.
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
Tyner et al., Lausanne, Switzerland. In Cancer Res, Feb 2016
Through this process, we identified tyrosine kinase nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.
Melikian et al., Worcester, United States. In Proc Natl Acad Sci U S A, Jan 2016
Here, we report that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane and is released in response to PKC activation.
Quantitative profiling of post-translational modifications by immunoaffinity enrichment and LC-MS/MS in cancer serum without immunodepletion.
Silva et al., United States. In Mol Cell Proteomics, Jan 2016
Of the PTMs identified, lysine acetylation (AcK) and arginine mono-methylation (Rme) were more prevalent than other PTMs.
Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.
Yang et al., Changsha, China. In Oncotarget, Jan 2016
Despite the substantial data supporting the oncogenic role of Ack1, the predictive value and biologic role of Ack1 in hepatocellular carcinoma (HCC) metastasis remains unknown.
The critical role of Akt in cardiovascular function.
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Ack1, Src, PTK6, TBK1, IKBKE and IKKε are some of the non-canonical pathways which affect the Akt activity.
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Mahajan et al., Tampa, United States. In Oncogene, Sep 2015
The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known as activated Cdc42-associated kinase 1 or TNK2) as an oncogenic kinase, has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression.
Schistosome sirtuins as drug targets.
Pierce et al., Lille, France. In Future Med Chem, 2014
The sirtuins form a superfamily of evolutionarily conserved NAD(+)-dependent protein N-ϵ-acyl-lysine (AcK) deacylases with roles in a variety of key cellular processes.
Current strategies in the diagnosis and management of chronic neutrophilic leukemia.
Zhao et al., Tianjin, China. In Chin Med J (engl), 2013
The oncogenic CSF3R mutations are molecular markers of sensitivity to inhibitors of the SRC family-TNK2 and JAK kinases and may provide a new avenue for therapy.
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.
Tyner et al., Portland, United States. In N Engl J Med, 2013
These mutations segregate within two distinct regions of CSF3R and lead to preferential downstream kinase signaling through SRC family-TNK2 or JAK kinases and differential sensitivity to kinase inhibitors.
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung.
Ramirez et al., Badalona, Spain. In Transl Lung Cancer Res, 2013
Broad 3q chromosome amplification is widely recognized as the most common chromosomal aberration found in SQCCL, where PIK3CA, SOX2, ACK1, PRKCI, TP63, PLD1, ECT2, and others genes are located.
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Mahajan et al., Tampa, United States. In J Biol Chem, 2012
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 tyrosine kinase activation correlates with pancreatic cancer progression.
Mahajan et al., Tampa, United States. In Am J Pathol, 2012
Ack1 activates AKT directly in pancreatic and other cancer cell lines by phosphorylating AKT at Tyr176 to promote cell survival.
The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.
Manser et al., Singapore, Singapore. In Biochem J, 2011
ACK1 is not autoinhibited but requires Src for activation.
A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Chayama et al., Hiroshima, Japan. In J Hepatol, 2011
SNP rs2278034 in ACK1 is associated with IFN therapy outcome in patients with HCV. ACK1 may play a role in innate and IFN-induced antiviral action against HCV.
[Correlation study of the overexpression of activated Cdc42-associated kinase 1 and the stage and prognosis of esophageal squamous cell carcinoma].
He et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, 2011
The up-regulated expressions of ACK1 protein and mRNA are correlated with the progression and prognosis of esophageal squamous cell carcinoma.
Redox regulation of germline and vulval development in Caenorhabditis elegans.
Hekimi et al., Montréal, Canada. In Science, 2004
One pathway depends on the oxidation of an analog of vertebrate low density lipoprotein (LDL) and acts on the germline through the Ack-related tyrosine kinase (ARK-1) kinase and inositol trisphosphate (IP3) signaling.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Iida et al., Minneapolis, United States. In Nat Cell Biol, 1999
MCSP-induced spreading of melanoma cells is dependent upon active Cdc42, a Cdc42-associated tyrosine kinase (Ack-1) and tyrosine phosphorylation of p130cas.
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Laue et al., Cambridge, United Kingdom. In Nature, 1999
Some of these, known as CRIB (for Cdc42/Rac interactive-binding) proteins, bind to both Cdc42 and Rac, such as the PAK1-3 serine/threonine kinases, whereas others are specific for Cdc42, such as the ACK tyrosine kinases and the Wiscott-Aldrich-syndrome proteins (WASPs).
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.
Takenawa et al., Tokyo, Japan. In Nature, 1998
Although there are several proteins such as PAK, ACK and WASP (Wiskott-Aldrich syndrome protein) that bind Cdc42 directly, none of these can account for the filopodium formation induced by Cdc42.
More papers using ACK antibodies
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
McKinnon Peter J. et al., In Nature neuroscience, 2006
... ACKNOWLEDGEMENTSWe thank the Hartwell Center for biotech support, the Transgenic core facility for blastocyst ...
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease
Shyong Tai E. et al., In Diabetes Care, 2005
... AcknowledgmentsThis work was supported by grants from the Biomedical Research Council (grant 03/1/27/18/216) ...
Isolation and characterization of a novel mouse lymphatic endothelial cell line: SV-LEC.
Ambati Jayakrishna et al., In Nature medicine, 2004
... ACKNOWLEDGMENTSWe thank various collaborators for gifts of transgenic mice, cell lines, and ...
Large-scale transient transfection of mammalian cells: a newly emerging attractive option for recombinant protein production
Owens Raymond J. et al., In Nucleic Acids Research, 2004
... ACKNOWLEDGEMENTSWe would like to thank Andrew Farmer of Clontech for his advice on ...
Image processing with ImageJ
Ackerman Susan L. et al., In Human Molecular Genetics, 2003
... ACKNOWLEDGEMENTSWe thank Dr Satoshi Ogawa for the Hyou1 targeted and transgenic mouse strains and the ...
Peptidase Substrates via Global Peptide Profiling
Saghatelian Alan et al., In Nature chemical biology, 2003
... AcknowledgementsThis work was supported by National Institutes of Health Grants 1DP2OD002374 (A.S.) and a Burroughs Wellcome Fund Career Award in the Biomedical Sciences (A.S.) ...
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability
Klungland Arne et al., In Nucleic Acids Research, 2002
... ACKNOWLEDGEMENTSThanks to the Norwegian transgenic centre, Oslo, and to ...
The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion
Kenny Paul J. et al., In Nature, 2001
... AcknowledgementsSupported by the National Institute on Drug Abuse (DA020686 to PJK; DA026693 to CDF; P30DA015663 to MJM), and The James and Esther King Biomedical Research Program, Florida Department ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
Galy Anne et al., In Molecular Therapy, 1996
... obtained by mechanic disruption of the tissue followed by removal of red blood cells with ACK lysis and magnetic immunoselection (Miltenyi Biotec, Bergisch Gladbach, Germany) using ...
Effect of a diet high in vegetables, fruit, and nuts on serum lipids
Anand Sonia S. et al., In Diabetes Care, 1996
... AcknowledgmentsThis study was supported by the Canadian Institutes of Health Research (grant MT-12790), the Heart and Stroke Foundation of Canada, and Merck Frosst Canada ...
Nanoscale 3D cellular imaging by axial scanning transmission electron tomography
Leapman Richard D. et al., In Nature methods, 1995
... ACKNOWLEDGMENTThis work was supported by the Intramural Research Programs of the National Institute of Biomedical Imaging and Bioengineering, and ...
The birth prevalence rates for the skeletal dysplasias
Briggs Michael D. et al., In Human Molecular Genetics, 1985
... ACKNOWLEDGEMENTSThe research was undertaken in the Wellcome Trust Centre for Cell-Matrix Research and the Histology, Microscopy and Transgenic Core Facilities of the ...
Square root transformation revisited
Shenoy Krishna V et al., In Nature neuroscience, 1971
... AcknowledgementsThis work was supported by a Helen Hay Whitney postdoctoral fellowship (MMC), Burroughs Welcome Fund Career Awards in the Biomedical Sciences (MMC, KVS), NIH ...
The use of confidence or fiducial limits illustrated in the case of the binomial
Murrell Adele et al., In Human Molecular Genetics, 1933
... ACKNOWLEDGEMENTSWe would like to acknowledge the support of the NIHR Cambridge Biomedical Research Centre, The University ...
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