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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glucosidase, alpha; acid

ACID, alpha-glucosidase, GAA, acid alpha-glucosidase, Glucan 1,4-alpha-Glucosidase, acid maltase
This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, Farr, Insulin
Papers using ACID antibodies
Friedreich ataxia in carriers of somatically unstable borderline GAA repeat alleles
Kirkpatrick David T., In PLoS ONE, 2003
... GAA repeat expansion-containing transgenic mice were crossed with ...
Papers on ACID
Quantitation of alpha-glucosidase activity using fluorinated carbohydrate array and MALDI-TOF-MS.
Cheng et al., In Acs Appl Mater Interfaces, Feb 2016
UNASSIGNED: Quantitation of alpha-glucosidase (α-GD) activity is of significance to diagnosis of many diseases including Pompe disease and type II diabetes.
Nonneurological Involvement in Late-Onset Friedreich Ataxia (LOFA): Exploring the Phenotypes.
França et al., Curitiba, Brazil. In Cerebellum, Feb 2016
UNASSIGNED: Friedreich's ataxia (FDRA) is the most common inherited ataxia worldwide, caused by homozygous GAA expansions in the FXN gene.
Guidelines for the diagnosis, treatment and clinical monitoring of patients with juvenile and adult Pompe disease.
Werneck et al., Rio de Janeiro, Brazil. In Arq Neuropsiquiatr, Jan 2016
A promising therapeutic perspective for PD is enzyme replacement therapy (ERT) with the human recombinant enzyme acid alpha-glucosidase (Myozyme®).
Disease-associated repeat instability and mismatch repair.
Pearson et al., Toronto, Canada. In Dna Repair (amst), Jan 2016
Recent advances have broadened our knowledge of both the MMR proteins involved in disease repeat expansions, including: MSH2, MSH3, MSH6, MLH1, PMS2, and MLH3, as well as the types of repeats affected by MMR, now including: (CAG)·(CTG), (CGG)·(CCG), and (GAA)·(TTC) repeats.
Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan.
Lui et al., Taiwan. In Plos One, Dec 2015
Patients who took thiazolidinedione, alpha-glucosidase inhibitors and insulin had a higher HZ risk than those taking metformin or sulphonylureas alone (aOR = 1.11, 1.14 and 1.18, p<0.001, respectively).
Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data.
Schulz et al., Aachen, Germany. In Lancet Neurol, Feb 2015
Age of disease onset was inversely correlated with the number of GAA repeats in the frataxin (FXN) gene: every 100 GAA repeats on the smaller repeat allele was associated with a 2·3 year (SE 0·2) earlier onset.
Antidiabetic potential of some less commonly used plants in traditional medicinal systems of India and Nigeria.
Rizvi et al., Allahābād, India. In J Intercult Ethnopharmacol, 2015
The present available treatment option for diabetes like sulfonylurea, metformin and alpha-glucosidase are restricted by their limited actions, secondary failure rates, and side-effects; and unaffordable to the majority of the population.
(GAA)n microsatellite as an indicator of the A genome reorganization during wheat evolution and domestication.
Salina et al., Novosibirsk, Russia. In Comp Cytogenet, 2014
In the present study we performed comparative analysis of the A genome chromosomes in diploid (Triticum urartu Tumanian ex Gandilyan, 1972, Triticum boeoticum Boissier, 1874 and Triticum monococcum Linnaeus, 1753) and polyploid wheat species representing two evolutionary lineages, Timopheevi (Triticum timopheevii (Zhukovsky) Zhukovsky, 1934 and Triticum zhukovskyi Menabde & Ericzjan, 1960) and Emmer (Triticum dicoccoides (Körnicke ex Ascherson & Graebner) Schweinfurth, 1908, Triticum durum Desfontaines, 1798, and Triticum aestivum Linnaeus, 1753) using a new cytogenetic marker - the pTm30 probe cloned from Triticum monococcum genome and containing (GAA)56 microsatellite sequence.
Review: Miglitol has potential as a therapeutic drug against obesity.
Hosoi et al., Ayabe, Japan. In Nutr Metab (lond), 2014
Miglitol is an alpha-glucosidase inhibitor (αGI) that is commonly used as an anti-diabetic drug, and there is growing evidence that it also has anti-obesity effects.
Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes.
Tenenbaum et al., Tel Aviv-Yafo, Israel. In Cardiovasc Diabetol, 2014
Meglitinides, glitazones and alpha-glucosidase inhibitors were subsequently developed, but the five mentioned groups of oral antihyperglycemic agents are associated with variable degrees of undesirable or even severe cardiovascular events.
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Liu et al., Hohhot, China. In Genet Mol Res, 2014
The frequency of haplotype GAA was significantly higher in the EH group than in controls in the Mongolian population.
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Festenstein et al., London, United Kingdom. In Lancet, 2014
Expanded GAA repeats within intron 1 of the frataxin (FXN) gene lead to its heterochromatinisation and transcriptional silencing.
Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas.
Okada et al., Pittsburgh, United States. In J Clin Oncol, 2014
Having identified a series of glioma-associated antigens (GAAs) commonly overexpressed in pediatric gliomas, we initiated a pilot study of subcutaneous vaccinations with GAA epitope peptides in HLA-A2-positive children with newly diagnosed BSG and HGG.
Transcriptional response to GAA deficiency (Pompe disease) in infantile-onset patients.
Pomponio et al., Framingham, United States. In Mol Genet Metab, 2012
Transcriptional response to GAA deficiency (Pompe disease) in infantile-onset patients
Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.
Bai et al., Tianjin, China. In Carbohydr Res, 2012
These results suggest that the N-terminal and C-terminal catalytic domains of maltase-glucoamylase differ in their substrate specificities and inhibitor tolerance despite their structural relationship
Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation.
Ohashi et al., Tokyo, Japan. In Mol Genet Metab, 2011
we define a critical role for endoplasmic reticulum stress in the activation of autophagy due to the 546G>T acid alpha glucosidase mutation
Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.
Hamaker et al., West Lafayette, United States. In Plos One, 2011
Findings suggest that C-terminal subunits of recombinant maltase-glucoamylase (MGAM) assists alpha-amylase in digesting starch molecules and potentially may compensate for developmental or pathological amylase deficiencies.
Structural insight into substrate specificity of human intestinal maltase-glucoamylase.
Shen et al., Tianjin, China. In Protein Cell, 2011
we report crystal structures of C-terminal maltase-glucoamylase alone at a resolution of 3.1 angstroms, and in complex with its inhibitor acarbose
A plastidial sodium-dependent pyruvate transporter.
Izui et al., Hiroshima, Japan. In Nature, 2011
Using differential transcriptome analyses of C(3) and C(4) plants of the genera Flaveria and Cleome, here we have identified a novel gene that is abundant in C(4) species, named BASS2 (BILE ACID:SODIUM SYMPORTER FAMILY PROTEIN 2).
Auxin triggers a genetic switch.
Jürgens et al., Tübingen, Germany. In Nat Cell Biol, 2011
Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes.
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