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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

N-acylsphingosine amidohydrolase 1

acid ceramidase, Asah1
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, PrP
Papers on acid ceramidase
Targeting acid ceramidase sensitises head and neck cancer to cisplatin.
Jang et al., Seoul, South Korea. In Eur J Cancer, Jan 2016
BACKGROUND: Acid ceramidase (AC), a key enzyme in ceramide metabolism, plays a role in cancer progression and resistance to therapy.
Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.
Piomelli et al., Genova, Italy. In J Med Chem, Jan 2016
The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity.
Atom based 3D-QSAR studies on 2,4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase.
Bhabak et al., Calcutta, India. In Eur J Pharm Sci, Jan 2016
Pharmacological inhibition of ceramidases and more particularly, acid ceramidase (aCDase) is suggestive of a chemotherapeutic approach as it increases the cellular concentration of ceramide inducing apoptosis.
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy.
Pierson et al., Los Angeles, United States. In Neuromuscul Disord, Dec 2015
Both disorders are autosomal recessive conditions caused by mutations in the ASAH1 gene encoding acid ceramidase.
Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides.
Raić-Malić et al., Zagreb, Croatia. In Acs Med Chem Lett, Dec 2015
Abrogation of acid ceramidase (ASAH1) expression of 9c and 9e indicated that these compounds could perturb ASAH1-mediated sphingolipid signaling.
Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition.
Piomelli et al., Italy. In J Biol Chem, Dec 2015
UNASSIGNED: Acid ceramidase (AC) is a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramides and concomitantly increasing those of sphingosine and its bioactive metabolite, sphingosine-1-phosphate (S1P).
Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications.
Cabot et al., Greenville, United States. In Biochim Biophys Acta, Sep 2015
Additionally, tamoxifen and metabolites N-desmethyltamoxifen and 4-hydroxytamoxifen, have been shown to inhibit ceramide hydrolysis by the enzyme acid ceramidase.
The ART of Lowering Ceramides.
Summers, Melbourne, Australia. In Cell Metab, Sep 2015
Using a genetic mouse model to acutely degrade ceramides in adipose tissue or the liver (i.e., by conditionally expressing acid ceramidase), in this issue of Cell MetabolismXia et al. (2015) identify roles for these molecules in insulin resistance, steatohepatitis, and interorgan communication.
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.
Scherer et al., Dallas, United States. In Cell Metab, Sep 2015
We have developed transgenic mice inducibly expressing acid ceramidase that display a reduction in ceramides in adult mouse tissues.
Inhibitors of Ceramidases.
Arenz et al., Berlin, Germany. In Chem Phys Lipids, Aug 2015
Acid ceramidase inhibition sensitizes certain types of cancer to chemo- and radio-therapy and this is suggestive of a role of acid ceramidase inhibitors as chemo-sensitizers which can act synergistically with chemo-therapeutic drugs.
The molecular medicine of acid ceramidase.
Schuchman et al., In Biol Chem, Jun 2015
Acid ceramidase (N-acylsphingosine deacylase, EC;
Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways.
Haimovitz-Friedman et al., In Biol Chem, Jun 2015
In particular, it has been shown that activation of the acid ceramidase can lead to the formation of sphingosine 1-phosphate, which then antagonizes ceramide signaling by initiating a pro-survival signaling pathway.
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase.
Tani et al., Fukuoka, Japan. In Biochim Biophys Acta, 2014
These enzymes are classified into three distinct groups, acid (Asah1), neutral (Asah2), and alkaline (Asah3) CDases, based on their primary structure and optimum pH.
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.
Kornhuber et al., Essen, Germany. In Nat Med, 2013
Mice overexpressing Asm, heterozygous for acid ceramidase, treated with blockers of ceramide metabolism or directly injected with C16 ceramide in the hippocampus had higher ceramide concentrations and lower rates of neuronal proliferation, maturation and survival compared with controls and showed depression-like behavior even in the absence of stress.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Hannun et al., Charleston, United States. In J Biol Chem, 2011
cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5.
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis.
Gulbins et al., Essen, Germany. In Nat Med, 2008
This change in pH results in an imbalance between acid sphingomyelinase (Asm) cleavage of sphingomyelin to ceramide and acid ceramidase consumption of ceramide, resulting in the higher levels of ceramide.
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.
Liu et al., Charleston, United States. In Cancer Biol Ther, 2007
AC is a critical regulator of prostate cancer progression by affecting not only tumor cell proliferation and migration but also responses to drug therapy
Acid ceramidase is a novel factor required for early embryo survival.
Schuchman et al., New York City, United States. In Faseb J, 2007
acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway
KLF6 is one transcription factor involved in regulating acid ceramidase gene expression.
Schuchman et al., New York City, United States. In Biochim Biophys Acta, 2006
These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6) is one transcription factor involved in the regulation of AC gene expression.
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging.
Schütze et al., Kiel, Germany. In Exp Dermatol, 2005
Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase have roles in cutaneous aging
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