Pharmacotherapy for mental health problems in people with intellectual disability.
Baltimore, United States. In Curr Opin Psychiatry, Feb 2016
Antidepressants may be poorly tolerated and might not be effective in reducing repetitive/stereotypic behaviors.In recent trials, glutamatergic and GABAergic agents for fragile X syndrome, and acetylcholinesterase inhibitors for Down's syndrome, failed to show efficacy.
Organophosphate pesticide exposure and neurodegeneration.
Almería, Spain. In Cortex, Nov 2015
Apart from the principle action of OPs which involves inhibition of the acetylcholinesterase (AChE) enzyme, several molecular targets, such as hormones; neurotransmitters; neurotrophic factors; enzymes related to the metabolism of beta amyloid protein as well as inflammatory changes have been identified for OP compounds.
Automated design of ligands to polypharmacological profiles.
Dundee, United Kingdom. In Nature, 2013
The method is demonstrated by the evolution of an approved acetylcholinesterase inhibitor drug into brain-penetrable ligands with either specific polypharmacology or exquisite selectivity profiles for G-protein-coupled receptors.
Chemically engineered extracts: source of bioactive compounds.
Rosario, Argentina. In Acc Chem Res, 2011
We isolated a semisynthetic β-glucosidase inhibitor from a CEE prepared by reaction with benzenesulfonyl chloride, an antifungal pyrazole from a CEE prepared by reaction with hydrazine, and an acetylcholinesterase inhibitor from a CEE prepared through bromination.