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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


acetylcholinesterase, AChE
Top mentioned proteins: CAN, Cholinesterase, ACID, HAD, V1a
Papers using acetylcholinesterase antibodies
Lyn kinase-dependent regulation of miR181 and myeloid cell leukemia-1 expression: implications for drug resistance in myelogenous leukemia
Soreq Hermona et al., In Frontiers in Molecular Neuroscience, 2009
... ) report for several of the latter technologies used to explore the miR-132 target AChE, and (Hansen et al., 2010) for the “classical” 3′-UTR and transgenic approaches, in exploring p250GAP ...
The PyMOL Molecular Graphics System
Darvesh Sultan et al., In Biochemistry, 2001
... ), and purified recombinant human AChE (∼1500, units as determined by the supplier) were purchased from Sigma Aldrich (St ...
Papers on acetylcholinesterase
AChE inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of Alzheimer's disease.
Chen et al., Shanghai, China. In Curr Neuropharmacol, Feb 2016
To date acetylcholinesterase inhibitors (AChEIs) have become the most prescribed drugs for the symptomatic treatment of mild to moderate AD.
Pharmacotherapy for mental health problems in people with intellectual disability.
Findling et al., Baltimore, United States. In Curr Opin Psychiatry, Feb 2016
Antidepressants may be poorly tolerated and might not be effective in reducing repetitive/stereotypic behaviors.In recent trials, glutamatergic and GABAergic agents for fragile X syndrome, and acetylcholinesterase inhibitors for Down's syndrome, failed to show efficacy.
Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia.
Suzuki et al., Tokyo, Japan. In Neurogastroenterol Motil, Feb 2016
The agent inhibits acetylcholinesterase in vitro and enhances muscle motility ex vivo.
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.
Liu et al., Linyi, China. In Bioorg Med Chem Lett, Feb 2016
These compounds were evaluated for in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities for possible benefit in Alzheimers disease (AD).
Effects of acetylcholinesterase inhibitors on cognitive function in patients with chronic traumatic brain injury: A systematic review.
Godbolt et al., Stockholm, Sweden. In J Rehabil Med, Jan 2016
OBJECTIVE: To undertake a systematic review of the evidence for the effect of acetylcholinesterase inhibitors (AChEIs) on cognition late after moderate or severe traumatic brain injury.
Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.
Bond et al., In J Vis Exp, Dec 2015
Exosomes were identified on the basis of exosome markers acetylcholinesterase (AChE), and the CD9, CD63, and CD45 antigens.
Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers.
Schmidt et al., Philadelphia, United States. In Transl Psychiatry, Dec 2015
Our previous studies demonstrated that acute administration of an acetylcholinesterase inhibitor (AChEI) attenuates nicotine taking and seeking in rats and suggest that AChEIs could be repurposed for smoking cessation.
Organophosphate pesticide exposure and neurodegeneration.
Herrero Hernández et al., Almería, Spain. In Cortex, Nov 2015
Apart from the principle action of OPs which involves inhibition of the acetylcholinesterase (AChE) enzyme, several molecular targets, such as hormones; neurotransmitters; neurotrophic factors; enzymes related to the metabolism of beta amyloid protein as well as inflammatory changes have been identified for OP compounds.
Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways.
Lewicki et al., Warsaw, Poland. In Cent Eur J Immunol, 2014
The non-neuronal acetylcholine is accompanied by the expression of acetylcholinesterase and nicotinic/muscarinic acetylcholine receptors.
Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.
Guarino et al., Minneapolis, United States. In Jama, 2014
OBJECTIVE: To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor.
Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial.
Miller et al., San Francisco, United States. In Lancet Neurol, 2013
Use of acetylcholinesterase inhibitors was prohibited.
Automated design of ligands to polypharmacological profiles.
Hopkins et al., Dundee, United Kingdom. In Nature, 2013
The method is demonstrated by the evolution of an approved acetylcholinesterase inhibitor drug into brain-penetrable ligands with either specific polypharmacology or exquisite selectivity profiles for G-protein-coupled receptors.
Valuing the Endangered Species Antirrhinum lopesianum: Neuroprotective Activities and Strategies for in vitro Plant Propagation.
Santos et al., Lisbon, Portugal. In Antioxidants (basel), 2012
Plant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration.
Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio).
Bogo et al., Porto Alegre, Brazil. In Neurotoxicology, 2012
Endosulfan exposure inhibits brain Ache activity and significantly impairs animals' exploratory performance, and potentially compromises their ecological and interspecific interaction.
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.
Renard et al., Mont-Saint-Aignan, France. In Acc Chem Res, 2012
The acute toxicity of OPNAs results from the irreversible inhibition of acetylcholinesterase (AChE, EC
Microcystin-LR acute exposure increases AChE activity via transcriptional ache activation in zebrafish (Danio rerio) brain.
Bogo et al., Porto Alegre, Brazil. In Comp Biochem Physiol C Toxicol Pharmacol, 2012
Findings provide evidence that brain acetylcholinesterase (AChE) is a potential target for microcystins (MCs).
Chemically engineered extracts: source of bioactive compounds.
Furlan et al., Rosario, Argentina. In Acc Chem Res, 2011
We isolated a semisynthetic β-glucosidase inhibitor from a CEE prepared by reaction with benzenesulfonyl chloride, an antifungal pyrazole from a CEE prepared by reaction with hydrazine, and an acetylcholinesterase inhibitor from a CEE prepared through bromination.
Expression of acetylcholinesterase (AChE) and aryl acylamidase (AAA) during early zebrafish embryogenesis.
Layer et al., Darmstadt, Germany. In Chem Biol Interact, 2006
aryl acylamidase associated with acetylcholinesterase was higher than the esterase activity on zebrafishembryo
Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability.
Granato et al., Philadelphia, United States. In Dev Biol, 2004
Results demonstrate that AChE is dispensable for its proposed non-classical roles in muscle fiber formation and sensory neuron development, but is crucial for regulating the stability of neuromuscular synapses.
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